Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration

Autor: Edgar E Nollet, Inez Duursma, Anastasiya Rozenbaum, Moritz Eggelbusch, Rob C I Wüst, Stephan A C Schoonvelde, Michelle Michels, Mark Jansen, Nicole N van der Wel, Kenneth C Bedi, Kenneth B Margulies, Jeff Nirschl, Diederik W D Kuster, Jolanda van der Velden

Publikováno v: Nollet, E E, Duursma, I, Rozenbaum, A, Eggelbusch, M, Wüst, R C I, Schoonvelde, S A C, Michels, M, Jansen, M, van der Wel, N N, Bedi, K C, Margulies, K B, Nirschl, J, Kuster, D W D & van der Velden, J 2023, ' Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration ', European heart journal . https://doi.org/10.1093/eurheartj/ehad028
European heart journal. Oxford University Press

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitocho

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https://hdl.handle.net/1871.1/0946409f-827c-4433-af9c-265b50db328c