Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ines Santolini"'
Autor:
Milena Cannella, Richard Teke Ngomba, Ines Santolini, Roberta Celli, Giada Mascio, Gilles van Luijtelaar, Matteo Vergassola, Mark J. Wall, Francisco Ciruela, Ferdinando Nicoletti, Luisa Di Menna, Valeria Bruno, Anna Pittaluga
Publikováno v:
Neuropharmacology, 178
Contains fulltext : 221388.pdf (Publisher’s version ) (Closed access) Contains fulltext : 221388pre.pdf (Author’s version preprint ) (Open Access) Previous studies have shown that injection of the mGlu5 receptor positive allosteric modulator (PAM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3dc02cab0dc7fd57d488a32122746e7
https://hdl.handle.net/2066/221388
https://hdl.handle.net/2066/221388
Autor:
Ferdinando Nicoletti, Roberta Celli, Ines Santolini, Valeria Bruno, Richard Teke Ngomba, Gilles van Luijtelaar
Publikováno v:
Expert Opinion on Therapeutic Targets, 23, 4, pp. 341-351
Expert Opinion on Therapeutic Targets, 23, 341-351
Expert Opinion on Therapeutic Targets, 23, 341-351
Contains fulltext : 201991.pdf (Publisher’s version ) (Open Access) Introduction: Several drugs targeting the GABAergic system are used in the treatment of epilepsy, but only one drug targeting glutamate receptors is on the market. This is surprisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d3f29f864171916179af689bbbd3ff
https://hdl.handle.net/2066/201991
https://hdl.handle.net/2066/201991
Autor:
Clementina M. van Rijn, Gilles van Luijtelaar, Ferdinando Nicoletti, Ines Santolini, Richard Teke Ngomba, Renée H.L. Raaijmakers, V. D'Amore
Publikováno v:
Pharmacology, Biochemistry and Behavior, 146-147, pp. 50-59
Pharmacology, Biochemistry and Behavior, 146-147, 50-59
Pharmacology, Biochemistry and Behavior, 146-147, 50-59
Ethosuximide (ETX) has become the drug of choice in the treatment of patients with absence seizures taking into account both its efficacy, tolerability and antiepileptogenic properties. However, 47% of subjects treated with ETX failed in therapy, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd262cc89ce24cd6c29c987df961574
https://hdl.handle.net/2066/157593
https://hdl.handle.net/2066/157593
Autor:
Ferdinando Nicoletti, Jane Tchekalarova, Domenico Bucci, Giuseppe Battaglia, Roberta Celli, Federica Mastroiacovo, Antonio De Fusco, Ines Santolini, Slavianka Moyanova
Publikováno v:
International Journal of Molecular Sciences
Volume 19
Issue 7
International Journal of Molecular Sciences, Vol 19, Iss 7, p 1973 (2018)
Volume 19
Issue 7
International Journal of Molecular Sciences, Vol 19, Iss 7, p 1973 (2018)
Absence epilepsy and depression are comorbid disorders, but the molecular link between the two disorders is unknown. Here, we examined the role of the melatoninergic system in the pathophysiology of spike and wave discharges (SWDs) and depression-lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e308b546f4631643e225f123cab2413c
http://hdl.handle.net/11573/1177276
http://hdl.handle.net/11573/1177276
Autor:
Ines, Santolini, Roberta, Celli, Milena, Cannella, Tiziana, Imbriglio, Michela, Guiducci, Pasquale, Parisi, Julian, Schubert, Michele, Iacomino, Federico, Zara, Holger, Lerche, Slavianka, Moyanova, Richard Teke, Ngomba, Gilles, van Luijtelaar, Giuseppe, Battaglia, Valeria, Bruno, Pasquale, Striano, Antonio, Gambardella
Publikováno v:
Epilepsia. 58(11)
Thrombospondins, which are known to interact with the αWe measured the transcripts of thrombospondin-1 and αThrombospondin-1 messenger RNA (mRNA) levels were largely reduced in the ventrobasal thalamus of both presymptomatic and symptomatic WAG/Rij
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea5ab39b71d43ce1eea14573c8bc23a6
https://pubmed.ncbi.nlm.nih.gov/28913875
https://pubmed.ncbi.nlm.nih.gov/28913875
Autor:
Michela Guiducci, Giuseppe Battaglia, Pasquale Parisi, Roberto Gradini, Gilles van Luijtelaar, Richard Teke Ngomba, Ines Santolini, Pasquale Striano, Ferdinando Nicoletti, Roberta Celli
Publikováno v:
Current Neuropharmacology, 15, 6, pp. 918-925
Current Neuropharmacology, 15, 918-925
Current Neuropharmacology
Current Neuropharmacology, 15, 918-925
Current Neuropharmacology
Background: Spike-wave discharges, underlying absence seizures, are generated within a cortico-thalamo-cortical network that involves the somatosensory cortex, the reticular thalamic nucleus, and the ventrobasal thalamic nuclei. Activation of T-type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e59d12077ac3d83ea7dc04c7d37f533
http://hdl.handle.net/11567/1022081
http://hdl.handle.net/11567/1022081
Autor:
F. Nicoletti, C.M. van Rijn, L. Lionetto, A. de Fusco, P.J. Conn, Paola Bosco, Maurizio Simmaco, Ines Santolini, V. D'Amore, Roberta Celli, E.L.J.M. van Luijtelaar, Richard Teke Ngomba, Shaun R. Stauffer, E. Vieira
Publikováno v:
Neuropharmacology, 85, 91-103
Neuropharmacology, 85, pp. 91-103
Neuropharmacology, 85, pp. 91-103
Item does not contain fulltext Acute treatment with positive allosteric modulators (PAMs) of mGlu1 and mGlu5 metabotropic glutamate receptors (RO0711401 and VU0360172, respectively) reduces the incidence of spike-and wave discharges in the WAG/Rij ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb438b6e9bf09580f5afb3c0fe97725
https://doi.org/10.1016/j.neuropharm.2014.05.005
https://doi.org/10.1016/j.neuropharm.2014.05.005
Autor:
E.L.J.M. van Luijtelaar, Shaun R. Stauffer, A. Prete, Ya Zhou, Francesca Biagioni, Craig W. Lindsley, Paige N. Vinson, Gemma Molinaro, Carrie K. Jones, C.M. van Rijn, P.J. Conn, F. Nicoletti, Richard Teke Ngomba, Ines Santolini, Alice L. Rodriguez, V. D'Amore
Publikováno v:
Neuropharmacology, 66, 330-338
Neuropharmacology, 66, pp. 330-338
Neuropharmacology, 66, pp. 330-338
Absence epilepsy is generated by the cortico-thalamo-cortical network, which undergoes a finely tuned regulation by metabotropic glutamate (mGlu) receptors. We have shown previously that potentiation of mGlu1 receptors reduces spontaneous occurring s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007659ab4e1d37ea33f07a07d8572c12
https://doi.org/10.1016/j.neuropharm.2012.05.044
https://doi.org/10.1016/j.neuropharm.2012.05.044
Autor:
G. Olivieri, Francesco Ferraguti, Giuseppe Battaglia, Gemma Molinaro, Federica Mastroiacovo, Roberto Gradini, Francesca Biagioni, Agnes Simonyi, Aldamaria Puliti, Richard Teke Ngomba, Ferdinando Nicoletti, G. van Luijtelaar, C.M. van Rijn, V. D'Amore, Valeria Bruno, Ines Santolini
Publikováno v:
Neuropharmacology, 60, 7-8, pp. 1281-1291
Neuropharmacology, 60, 1281-1291
Neuropharmacology, 60, 1281-1291
Eight-month old WAG/Rij rats, which developed spontaneous occurring absence seizures, showed a reduced function of mGlu1 metabotropic glutamate receptors in the thalamus, as assessed by in vivo measurements of DHPG-stimulated polyphosphoinositide hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4544b9ffeecf7bffe29902a355dcbb5
https://doi.org/10.1016/j.neuropharm.2011.01.007
https://doi.org/10.1016/j.neuropharm.2011.01.007
Autor:
Francesco Ferraguti, Richard Teke Ngomba, Giuseppe Battaglia, Ines Santolini, Ferdinando Nicoletti, Gilles van Luijtelaar, Thomas E. Salt
Publikováno v:
Epilepsia. 52:1211-1222
Metabotropic glutamate (mGlu) receptors are positioned at synapses of the thalamocortical network that underlie the development of spike-and-wave discharges (SWDs) associated with absence epilepsy. The modulatory role of individual mGlu receptor subt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::121140a771583700b505ea0b13212b7e
https://doi.org/10.1111/j.1528-1167.2011.03082.x
https://doi.org/10.1111/j.1528-1167.2011.03082.x