Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Ines Pires Da Silva"'
Autor:
Xinyu Bai, Grace H. Attrill, Tuba N. Gide, Peter M. Ferguson, Kazi J. Nahar, Ping Shang, Ismael A. Vergara, Umaimainthan Palendira, Ines Pires da Silva, Matteo S. Carlino, Alexander M. Menzies, Georgina V. Long, Richard A. Scolyer, James S. Wilmott, Camelia Quek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The biological underpinnings of therapeutic resistance to immune checkpoint inhibitors (ICI) in adolescent and young adult (AYA) melanoma patients are incompletely understood. Here, we characterize the immunogenomic profile and spatial archi
Externí odkaz:
https://doaj.org/article/4e3968539ed44b5d8e921475912375ae
Autor:
Lauren Julia Brown, Victor Khou, Chris Brown, Marliese Alexander, Dasantha Jayamanne, Joe Wei, Lauren Gray, Wei Yen Chan, Samuel Smith, Susan Harden, Antony Mersiades, Lydia Warburton, Malinda Itchins, Jenny H. Lee, Nick Pavlakis, Stephen J. Clarke, Michael Boyer, Adnan Nagrial, Eric Hau, Ines Pires da Silva, Steven Kao, Benjamin Y. Kong
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionBrain metastases commonly occur in patients with non-small cell lung cancer (NSCLC). Standard first-line treatment for NSCLC, without an EGFR, ALK or ROS1 mutation, is either chemoimmunotherapy or anti-PD-1 monotherapy. Traditionally, pat
Externí odkaz:
https://doaj.org/article/091bc647cc054317a5b3754310f54a38
Autor:
Tuba N. Gide, Elizabeth C. Paver, Zarwa Yaseen, Nigel Maher, Nurudeen Adegoke, Alexander M. Menzies, Ines Pires da Silva, James S. Wilmott, Georgina V. Long, Richard A. Scolyer
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTLymphocyte-activation gene-3 (LAG-3), an immune checkpoint receptor, negatively regulates T-cell function and facilitates immune escape of tumors. Dual inhibition of LAG-3 and programmed cell death receptor-1 (PD-1) significantly improved pro
Externí odkaz:
https://doaj.org/article/de51474a80d24f65bee9d63be6c7447f
Autor:
Georgina V Long, Richard A Scolyer, Alexander M Menzies, James S Wilmott, Tuba N Gide, Yizhe Mao, Ella McCutcheon, Nigel Maher, Ping Shang, Ines Pires da Silva
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/5de7196c43d843708c25b2703a85df27
Autor:
Ines Pires da Silva, Richard A Scolyer, Georgina Long, Matteo S Carlino, Ismael A Vergara, James S Wilmott, Serigne N Lo, Tuba N Gide, Alexander Maxwell Menzies, Nurudeen A Adegoke, Yizhe Mao, Camelia Quek, Ellis Patrick
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Background Tumor microenvironment (TME) characteristics are potential biomarkers of response to immune checkpoint inhibitors in metastatic melanoma. This study developed a method to perform unsupervised classification of TME of metastatic melanoma.Me
Externí odkaz:
https://doaj.org/article/6850a655f74044878275417fb41be554
Autor:
Lauren J Brown, Ines Pires da Silva, Tania Moujaber, Bo Gao, Rina Hui, Howard Gurney, Matteo Carlino, Adnan Nagrial
Publikováno v:
Cancer Medicine, Vol 12, Iss 6, Pp 6788-6801 (2023)
Abstract Aims There is robust trial evidence for improved overall survival (OS) with immunotherapy in advanced solid organ malignancies. The real‐world long‐term survival data and the predictive variables are not yet known. Our aim was to evaluat
Externí odkaz:
https://doaj.org/article/6bb5dd3aed074dbb932c0084ce042e5f
Autor:
Jordan W. Conway, Jorja Braden, Serigne N. Lo, Richard A. Scolyer, Matteo S. Carlino, Alexander M. Menzies, Georgina V. Long, Ines Pires da Silva
Publikováno v:
Cancers, Vol 15, Iss 20, p 5012 (2023)
Background: Liver metastases are associated with poor prognosis across cancers. Novel treatment strategies to treat patients with liver metastases are needed. This meta-analysis aimed to assess the efficacy of vascular endothelial growth factor inhib
Externí odkaz:
https://doaj.org/article/d1057c5eacaf45fe87df2f6fcb6ba45f
Autor:
Kazi J. Nahar, Felix Marsh-Wakefield, Robert V. Rawson, Tuba N. Gide, Angela L. Ferguson, Ruth Allen, Camelia Quek, Ines Pires da Silva, Stephen Tattersal, Christopher J. Kiely, Neomal Sandanayake, Matteo S. Carlino, Geoff McCaughan, James S. Wilmott, Richard A. Scolyer, Georgina V. Long, Alexander M. Menzies, Umaimainthan Palendira
Publikováno v:
JCI Insight, Vol 7, Iss 21 (2022)
Immune-related adverse events represent a major hurdle to the success of immunotherapy. The immunological mechanisms underlying their development and relation to antitumor responses are poorly understood. By examining both systemic and tissue-specifi
Externí odkaz:
https://doaj.org/article/3735f33fbccb4897a34d7c5e7b464466
Autor:
Eva R. Shteinman, James S. Wilmott, Ines Pires da Silva, Georgina V. Long, Richard A. Scolyer, Ismael A. Vergara
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Aneuploidy, the state of the cell in which the number of whole chromosomes or chromosome arms becomes imbalanced, has been recognized as playing a pivotal role in tumor evolution for over 100 years. In melanoma, the extent of aneuploidy, as well as t
Externí odkaz:
https://doaj.org/article/402df30310de447fa50da6bee3d68f22
Autor:
John F Thompson, Serigne Lo, Ines Pires da Silva, Georgina V Long, Richard A Scolyer, Andrew J Spillane, Robert V Rawson, Tasnia Ahmed, Jordan W Conway, Matteo S Carlino, Ismael A Vergara, James S Wilmott, Grace Heloise Attrill, Tuba N Gide, Robyn P M Saw, Kerwin F Shannon, Brindha Shivalingam, Alexander Maxwell Menzies
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background The liver is a known site of resistance to immunotherapy and the presence of liver metastases is associated with shorter progression-free and overall survival (OS) in melanoma, while lung metastases have been associated with a more favorab
Externí odkaz:
https://doaj.org/article/c656c5775fc74e02a519bcf5c3149e12