Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Ines Neundorf"'
Autor:
Ishier Raote, Ann-Helen Rosendahl, Hanna-Maria Häkkinen, Carina Vibe, Ismail Küçükaylak, Mugdha Sawant, Lena Keufgens, Pia Frommelt, Kai Halwas, Katrina Broadbent, Marina Cunquero, Gustavo Castro, Marie Villemeur, Julian Nüchel, Anna Bornikoel, Binita Dam, Ravindra K. Zirmire, Ravi Kiran, Carlo Carolis, Jordi Andilla, Pablo Loza-Alvarez, Verena Ruprecht, Colin Jamora, Felix Campelo, Marcus Krüger, Matthias Hammerschmidt, Beate Eckes, Ines Neundorf, Thomas Krieg, Vivek Malhotra
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Uncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring and fibrosis and compromise tissue function. Despite the widespread occurrence of fibrotic diseases and scarring, effective therapies are lacking. A pro
Externí odkaz:
https://doaj.org/article/252118aa60de4fe1a96942bcae197b43
Autor:
Denise Meinberger, Marco G. Drexelius, Joshua Grabeck, Gabriele Hermes, Annika Roth, Dzemal Elezagic, Ines Neundorf, Thomas Streichert, Andreas R. Klatt
Publikováno v:
Antibiotics, Vol 12, Iss 10, p 1532 (2023)
Antimicrobial peptides (AMPs) represent a promising alternative to conventional antibiotics. Sequence changes can significantly improve the therapeutic properties of antimicrobial peptides. In our study, we apply different sequence modifications to e
Externí odkaz:
https://doaj.org/article/443eba95fde3488bb2fa481aff721d14
Publikováno v:
Molecules, Vol 27, Iss 19, p 6656 (2022)
Herein, the design and synthesis of peptide-drug conjugates (PDCs) including different variants of the cell-penetrating peptide sC18 is presented. We first generated a series of novel sequence mutants of sC18 having either amino acid deletions and/or
Externí odkaz:
https://doaj.org/article/58b011ca411848509644073ebcce86aa
Autor:
Sewar Alkhashrom, Jintawee Kicuntod, Katharina Stillger, Tamara Lützenburg, Christian Anzenhofer, Ines Neundorf, Manfred Marschall, Jutta Eichler
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1040 (2022)
The replication of human cytomegalovirus (HCMV) involves a process termed nuclear egress, which enables translocation of newly formed viral capsids from the nucleus into the cytoplasm. The HCMV core nuclear egress complex (core NEC), a heterodimer of
Externí odkaz:
https://doaj.org/article/3cf3b52baba4452698d2aa20abc57a92
Autor:
Martin Matijass, Ines Neundorf
Publikováno v:
Medicine in Drug Discovery, Vol 10, Iss , Pp 100092- (2021)
Peptides have gained more and more interest as therapeutics for different fields of medical indications. Built up via a peptide bond from naturally occurring amino acids they stand out by their high target selectivity and good biocompatibility. Howev
Externí odkaz:
https://doaj.org/article/87fcc76ed85d46cea29f46cb3b9fa11e
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 5071 (2022)
The human gonadotropin releasing hormone (GnRH-I) and its sea lamprey analogue GnRH-III specifically bind to GnRH receptors on cancer cells and can be used as targeting moieties for targeted tumor therapy. Considering that the selective release of dr
Externí odkaz:
https://doaj.org/article/15d665ff4feb41e794d30225838ed6cc
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 1378-1388 (2018)
Within this study, we report about the design and biological characterization of novel cell-penetrating peptides (CPPs) with selective suborganelle-targeting properties. The nuclear localization sequence N50, as well as the nucleoli-targeting sequenc
Externí odkaz:
https://doaj.org/article/6d83860905704a3f95af7e683ff59775
Autor:
Marco G. Drexelius, Ines Neundorf
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13212 (2021)
Biofilm formation and inflammations are number one reasons of implant failure and cause a severe number of postoperative complications every year. To functionalize implant surfaces with antibiotic agents provides perspectives to minimize and/or preve
Externí odkaz:
https://doaj.org/article/5d72102f321044388bb02d706891fae8
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2075 (2021)
Cell-penetrating peptides (CPPs) have emerged as versatile tools to increase the intracellular accumulation of different kinds of cargoes. For an efficient cellular uptake and drug delivery, their organization into a distinct and stable secondary str
Externí odkaz:
https://doaj.org/article/22c21d5d9add4cb5b50292ab969d07c0
Publikováno v:
Molecules, Vol 26, Iss 6, p 1591 (2021)
This review summarizes recent developments in conjugation techniques for the synthesis of cell-penetrating peptide (CPP)–drug conjugates targeting cancer cells. We will focus on small organic molecules as well as metal complexes that were used as c
Externí odkaz:
https://doaj.org/article/497aed6745e34ef3a8c5976bc8ec0885