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pro vyhledávání: '"Ines M J Hofer"'
Autor:
Sarah J Rice, Abby Brumwell, Julia Falk, Yulia S Kehayova, John Casement, Eleanor Parker, Ines M J Hofer, Colin Shepherd, John Loughlin
Publikováno v:
Human Molecular Genetics.
Osteoarthritis (OA) is a polygenic disease of older people resulting in the breakdown of cartilage within articular joints. Although it is a leading cause of disability, there are no disease-modifying therapies. Evidence is emerging to support the or
Autor:
Lucy Earl, Sarah J. Rice, Ines M. J. Hofer, John Loughlin, E. Parker, Sami A. Anjum, David J. Deehan
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.)REFERENCES. 73(1)
Objective Osteoarthritis (OA) is polygenic, with more than 90 risk loci currently mapped, including at the single-nucleotide polymorphism rs6516886. Previous analysis of OA cartilage DNA identified 6 CpG dinucleotides whose methylation levels correla
Autor:
Ines M. J. Hofer, Sarah J. Rice, Kathleen Cheung, John Loughlin, David J. Deehan, E. Parker, Antony K. Sorial, M. Tselepi
Publikováno v:
Osteoarthritis and Cartilage
ObjectiveOsteoarthritis (OA) associated single nucleotide polymorphism (SNP) rs11780978 correlates with differential expression of PLEC, and methylation quantitative trait loci (mQTLs) at PLEC CpGs in cartilage. This implies that methylation links ch