Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Ines Lohse"'
Autor:
Ryan A. Lacinski, Sebastian A. Dziadowicz, Vincent K. Melemai, Brody Fitzpatrick, John J. Pisquiy, Tanya Heim, Ines Lohse, Karen E. Schoedel, Nicolas J. Llosa, Kurt R. Weiss, Brock A. Lindsey
Publikováno v:
Bone Research, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract Patients diagnosed with advanced osteosarcoma, often in the form of lung metastases, have abysmal five-year overall survival rates. The complexity of the osteosarcoma immune tumor microenvironment has been implicated in clinical trial failur
Externí odkaz:
https://doaj.org/article/31577f7a21fd4545a7a68ae99e5fce12
Autor:
Ismaeel A. Siddiqui, Nickolas Littlefield, Luke A. Carlson, Matthew Gong, Avani Chhabra, Zoe Menezes, George M. Mastorakos, Sakshi Mehul Thakar, Mehrnaz Abedian, Ines Lohse, Kurt R. Weiss, Johannes F. Plate, Hamidreza Moradi, Soheyla Amirian, Ahmad P. Tafti
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract AI-powered segmentation of hip and knee bony anatomy has revolutionized orthopedics, transforming pre-operative planning and post-operative assessment. Despite the remarkable advancements in AI algorithms for medical imaging, the potential f
Externí odkaz:
https://doaj.org/article/9568bc673d3244049378411bb68ad069
Autor:
Ryan A. Lacinski, Sebastian A. Dziadowicz, Clark A. Roth, Li Ma, Vincent K. Melemai, Brody Fitzpatrick, Edwin Chaharbakhshi, Tanya Heim, Ines Lohse, Karen E. Schoedel, Gangqing Hu, Nicolas J. Llosa, Kurt R. Weiss, Brock A. Lindsey
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundThe large-scale proteomic platform known as the SomaScan® assay is capable of simultaneously measuring thousands of proteins in patient specimens through next-generation aptamer-based multiplexed technology. While previous studies have uti
Externí odkaz:
https://doaj.org/article/c6e6642921e84a7f8c0d9174500fdaf9
Publikováno v:
Livers, Vol 2, Iss 3, Pp 185-213 (2022)
Liver cancer ranks as the fourth leading cause of cancer-related deaths. Despite extensive research efforts aiming to evaluate the biological mechanisms underlying hepatocellular carcinoma (HCC) development, little has been translated towards new dia
Externí odkaz:
https://doaj.org/article/abb02cd31e664265af44bac12262760a
Autor:
Jessica Dennison, Armando Mendez, Angela Szeto, Ines Lohse, Claes Wahlestedt, Claude-Henry Volmar
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1324 (2023)
Epigenetic compounds have become attractive small molecules for targeting the multifaceted aspects of Alzheimer’s disease (AD). Although AD disproportionately affects women, most of the current literature investigating epigenetic compounds for the
Externí odkaz:
https://doaj.org/article/e6eb94147a5649e6876caa0e49838f42
Autor:
Shayan Khalafi, Shoumin Zhu, Rimpi Khurana, Ines Lohse, Silvia Giordano, Simona Corso, Hassan Al-Ali, Shaun P. Brothers, Claes Wahlestedt, Stephan Schürer, Wael El-Rifai
Publikováno v:
Translational Oncology, Vol 15, Iss 1, Pp 101260- (2022)
Gastric cancer (GC) is frequently characterized by resistance to standard chemotherapeutic regimens and poor clinical outcomes. We aimed to identify a novel therapeutic approach using drug sensitivity testing (DST) and our computational SynerySeq pip
Externí odkaz:
https://doaj.org/article/8eeeb20b5800473cb4749dd0deb8d23c
Publikováno v:
Molecular Cancer, Vol 18, Iss 1, Pp 1-13 (2019)
Abstract Cells respond to hypoxia by shifting cellular processes from general housekeeping functions to activating specialized hypoxia-response pathways. Oxygen plays an important role in generating ATP to maintain a productive rate of protein synthe
Externí odkaz:
https://doaj.org/article/b09c36362915423fa936bc15a22f2946
Autor:
Sabrina N. Copsel, Casey O. Lightbourn, Henry Barreras, Ines Lohse, Dietlinde Wolf, Cameron S. Bader, John Manov, Brandon J. Kale, Devangi Shah, Shaun P. Brothers, Victor L. Perez, Krishna V. Komanduri, Claes Wahlestedt, Robert B. Levy
Publikováno v:
Frontiers in Immunology, Vol 9 (2019)
A recent approach for limiting production of pro-inflammatory cytokines has been to target bromodomain and extra-terminal (BET) proteins. These epigenetic readers of histone acetylation regulate transcription of genes involved in inflammation, cardio
Externí odkaz:
https://doaj.org/article/9cc5a389d4de4657b305b7b1c9f3af61
Autor:
Qiang Zhang, Yaqing Zhang, Joshua D. Parsels, Ines Lohse, Theodore S. Lawrence, Marina Pasca di Magliano, Yi Sun, Meredith A. Morgan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 11, Pp 666-673 (2016)
Pancreatic cancers driven by KRAS mutations require additional mutations for tumor progression. The tumor suppressor FBXW7 is altered in pancreatic cancers, but its contribution to pancreatic tumorigenesis is unknown. To determine potential cooperati
Externí odkaz:
https://doaj.org/article/f0b258a5d25a477bbda0001384e57cba
Autor:
Ines Lohse, Hassan Al-Ali, Claude-Henry Volmar, Annamil D Alvarez Trotta, Shaun P Brothers, Anthony J Capobianco, Claes Wahlestedt
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0203173 (2018)
BACKGROUND:Esophageal cancer remains one of the hardest cancers to treat with rising incidence rates, low overall survival and high levels of treatment resistance. The lack of clinically available biomarkers hinder diagnosis and treatment stratificat
Externí odkaz:
https://doaj.org/article/6a3b6d8ba6f34f338c34fee44b607420