Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Ines Kühnel"'
Autor:
Jordi Pfeifer Serrahima, Katrin Schoenfeld, Ines Kühnel, Julia Harwardt, Arturo Macarrón Palacios, Maren Prüfer, Margareta Kolaric, Pranav Oberoi, Harald Kolmar, Winfried S. Wels
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
NKG2D is an activating receptor expressed by natural killer (NK) cells and other cytotoxic lymphocytes that plays a pivotal role in the elimination of neoplastic cells through recognition of different stress-induced cell surface ligands (NKG2DL). To
Externí odkaz:
https://doaj.org/article/af94d95b092647eebbb988a5701ced76
Autor:
Anne Kiefer, Maren Prüfer, Jasmin Röder, Jordi Pfeifer Serrahima, Malena Bodden, Ines Kühnel, Pranav Oberoi, Winfried S. Wels
Publikováno v:
Cells, Vol 13, Iss 3, p 246 (2024)
NKG2D is an activating receptor of natural killer cells that recognizes stress-induced ligands (NKG2DL) expressed by many tumor cells. Nevertheless, NKG2DL downregulation or shedding can still allow cancer cells to evade immune surveillance. Here, we
Externí odkaz:
https://doaj.org/article/b66612773bab4b5798e540f539508d19
Autor:
Jordi Pfeifer Serrahima, Congcong Zhang, Pranav Oberoi, Malena Bodden, Jasmin Röder, Claudia Arndt, Anja Feldmann, Anne Kiefer, Maren Prüfer, Ines Kühnel, Torsten Tonn, Michael Bachmann, Winfried S. Wels
Publikováno v:
Cancer Immunology, Immunotherapy.
Chimeric antigen receptor (CAR)-engineered immune effector cells constitute a promising approach for adoptive cancer immunotherapy. Nevertheless, on-target/off-tumor toxicity and immune escape due to antigen loss represent considerable challenges. Th