The model of local axon homeostasis - explaining the role and regulation of microtubule bundles in axon maintenance and pathology

Autor: Ines Hahn, André Voelzmann, Yu-Ting Liew, Beatriz Costa-Gomes, Andreas Prokop

Publikováno v: Neural Development, Vol 14, Iss 1, Pp 1-28 (2019)

Abstract Axons are the slender, cable-like, up to meter-long projections of neurons that electrically wire our brains and bodies. In spite of their challenging morphology, they usually need to be maintained for an organism's lifetime. This makes them

Externí odkaz: https://doaj.org/article/cc49e45a31e041a78115bd47689071b9

Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex

Autor: Yue Qu, Ines Hahn, Meredith Lees, Jill Parkin, André Voelzmann, Karel Dorey, Alex Rathbone, Claire T Friel, Victoria J Allan, Pilar Okenve-Ramos, Natalia Sanchez-Soriano, Andreas Prokop

Publikováno v: eLife, Vol 8 (2019)

Cortical collapse factors affect microtubule (MT) dynamics at the plasma membrane. They play important roles in neurons, as suggested by inhibition of axon growth and regeneration through the ARF activator Efa6 in C. elegans, and by neurodevelopmenta

Externí odkaz: https://doaj.org/article/4f7597d325c748c2846b745dd23b04fa

Re‐evaluating the actin‐dependence of spectraplakin functions during axon growth and maintenance

Autor: Yue Qu, Natalia Sanchez-Soriano, Jill Parkin, Ines Hahn, Andreas Prokop, Kriti Gupta, Juliana Alves-Silva

Publikováno v: Developmental Neurobiology
Qu, Y, Alves-Silva, J, Gupta, K, Hahn, I, Parkin, J, Sanchez-Soriano, N & Prokop, A 2022, ' Re-evaluating the actin-dependence of spectraplakin functions during axon growth and maintenance ', Developmental Neurobiology, vol. 82, no. 4, pp. 288-307 . https://doi.org/10.1002/dneu.22873

Axons are the long and slender processes of neurons constituting the biological cables that wire the nervous system. The growth and maintenance of axons require bundles of microtubules that extend through their entire length. Understanding microtubul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c5c217c94ffd451d4235bea0d71e4e
http://livrepository.liverpool.ac.uk/3151921/1/Qu+al.pdf

Periodic actin structures in neuronal axons are required to maintain microtubules

Autor: Stephen E. D. Webb, Ines Hahn, Simon P. Pearce, Yue Qu, Andreas Prokop

Publikováno v: Molecular Biology of the Cell
Qu, Y, Hahn, I, Webb, S, Pearce, S & Prokop, A 2017, ' Periodic actin structures in neuronal axons are required to maintain microtubules ', Molecular Biology of the Cell, vol. 28, no. 296-308, mbc.E16-10-0727, pp. 296-308 . https://doi.org/10.1091/mbc.E16-10-0727

Drosophila genetics is combined with high-resolution microscopy and a number of functional readouts to demonstrate key factors required for the presence of regularly spaced rings of cortical actin in axons. The data suggest important roles for the ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9bc726e77ae0d89c2df7d95dfbea16
https://doi.org/10.1091/mbc.e16-10-0727

DrosophilaShort stop as a paradigm for the role and regulation of spectraplakins

Autor: Natalia Sanchez-Soriano, Andreas Prokop, Cristina Melero, Yu Ting Liew, Ines Hahn, André Voelzmann, Yue Qu

Publikováno v: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Voelzmann, A, Liew, Y T, Qu, Y, Hahn, I, Melero, C, Sanchez-Soriano, N & Prokop, A 2017, ' Drosophila Short stop as a paradigm for the role and regulation of spectraplakins ', Seminars in Cell and Developmental Biology, vol. 69, YSCDB2225, pp. 40-57 . https://doi.org/10.1016/j.semcdb.2017.05.019

Spectraplakins are evolutionarily well conserved cytoskeletal linker molecules that are true members of three protein families: plakins, spectrins and Gas2-like proteins. Spectraplakin genes encode at least 7 characteristic functional domains which a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d36fe5acdbb62dfc3ef36375e62b403
https://doi.org/10.1101/122010