Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ines Hahn"'
Autor:
Ryan J. H. West, Joanne L. Sharpe, André Voelzmann, Anna L. Munro, Ines Hahn, Richard A. Baines, Stuart Pickering-Brown
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Abstract A large intronic hexanucleotide repeat expansion (GGGGCC) within the C9orf72 (C9orf72-SMCR8 Complex Subunit) locus is the most prevalent genetic cause of both Frontotemporal Dementia (FTD) and Motor Neuron Disease (MND). In patients this exp
Externí odkaz:
https://doaj.org/article/4e9a52c5a5ea4a479ca7cd7829ad0e49
Autor:
Ines Hahn, Andre Voelzmann, Jill Parkin, Judith B Fülle, Paula G Slater, Laura Anne Lowery, Natalia Sanchez-Soriano, Andreas Prokop
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009647 (2021)
The formation and maintenance of microtubules requires their polymerisation, but little is known about how this polymerisation is regulated in cells. Focussing on the essential microtubule bundles in axons of Drosophila and Xenopus neurons, we show t
Externí odkaz:
https://doaj.org/article/c5e8e8f422334f6baa0209cb9072db39
Publikováno v:
Neural Development, Vol 14, Iss 1, Pp 1-28 (2019)
Abstract Axons are the slender, cable-like, up to meter-long projections of neurons that electrically wire our brains and bodies. In spite of their challenging morphology, they usually need to be maintained for an organism's lifetime. This makes them
Externí odkaz:
https://doaj.org/article/cc49e45a31e041a78115bd47689071b9
Autor:
Yue Qu, Ines Hahn, Meredith Lees, Jill Parkin, André Voelzmann, Karel Dorey, Alex Rathbone, Claire T Friel, Victoria J Allan, Pilar Okenve-Ramos, Natalia Sanchez-Soriano, Andreas Prokop
Publikováno v:
eLife, Vol 8 (2019)
Cortical collapse factors affect microtubule (MT) dynamics at the plasma membrane. They play important roles in neurons, as suggested by inhibition of axon growth and regeneration through the ARF activator Efa6 in C. elegans, and by neurodevelopmenta
Externí odkaz:
https://doaj.org/article/4f7597d325c748c2846b745dd23b04fa
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97332 (2014)
Phosphoinositide-3-kinase enhancer (PIKE) proteins encoded by the PIKE/CENTG1 gene are members of the gamma subgroup of the Centaurin superfamily of small GTPases. They are characterized by their chimeric protein domain architecture consisting of a p
Externí odkaz:
https://doaj.org/article/5c97dfede31d45fc8d89b7acc4d868f0
Autor:
Yue Qu, Natalia Sanchez-Soriano, Jill Parkin, Ines Hahn, Andreas Prokop, Kriti Gupta, Juliana Alves-Silva
Publikováno v:
Developmental Neurobiology
Qu, Y, Alves-Silva, J, Gupta, K, Hahn, I, Parkin, J, Sanchez-Soriano, N & Prokop, A 2022, ' Re-evaluating the actin-dependence of spectraplakin functions during axon growth and maintenance ', Developmental Neurobiology, vol. 82, no. 4, pp. 288-307 . https://doi.org/10.1002/dneu.22873
Qu, Y, Alves-Silva, J, Gupta, K, Hahn, I, Parkin, J, Sanchez-Soriano, N & Prokop, A 2022, ' Re-evaluating the actin-dependence of spectraplakin functions during axon growth and maintenance ', Developmental Neurobiology, vol. 82, no. 4, pp. 288-307 . https://doi.org/10.1002/dneu.22873
Axons are the long and slender processes of neurons constituting the biological cables that wire the nervous system. The growth and maintenance of axons require bundles of microtubules that extend through their entire length. Understanding microtubul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c5c217c94ffd451d4235bea0d71e4e
http://livrepository.liverpool.ac.uk/3151921/1/Qu+al.pdf
http://livrepository.liverpool.ac.uk/3151921/1/Qu+al.pdf
Autor:
Judith B Fuelle, André Voelzmann, Laura Anne Lowery, Ines Hahn, Andreas Prokop, Natalia Sanchez-Soriano, Paula G. Slater, Jill Parkin
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009647 (2021)
Hahn, I, Voelzmann, A, Parkin, J, Fülle, J B, Slater, P G, Lowery, L A, Sanchez-Soriano, N & Prokop, A 2021, ' Tau, XMAP215/Msps and Eb1 co-operate interdependently to regulate microtubule polymerisation and bundle formation in axons ', PLoS Genetics, vol. 17, no. 7, 1009647 . https://doi.org/10.1371/journal.pgen.1009647
PLoS Genetics
PLOS GENETICS
Hahn, I, Voelzmann, A, Parkin, J, Fülle, J B, Slater, P G, Lowery, L A, Sanchez-Soriano, N & Prokop, A 2021, ' Tau, XMAP215/Msps and Eb1 co-operate interdependently to regulate microtubule polymerisation and bundle formation in axons ', PLoS Genetics, vol. 17, no. 7, 1009647 . https://doi.org/10.1371/journal.pgen.1009647
PLoS Genetics
PLOS GENETICS
The formation and maintenance of microtubules requires their polymerisation, but little is known about how this polymerisation is regulated in cells. Focussing on the essential microtubule bundles in axons of Drosophila and Xenopus neurons, we show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17abca2879f65f60eb95a33dfe6642b
https://doaj.org/article/c5e8e8f422334f6baa0209cb9072db39
https://doaj.org/article/c5e8e8f422334f6baa0209cb9072db39
Publikováno v:
Neural Development, Vol 14, Iss 1, Pp 1-28 (2019)
Neural Development
Hahn, I, Voelzmann, A, Liew, Y T, Costa Gomes, B & Prokop, A 2019, ' The model of local axon homeostasis-explaining the role and regulation of microtubule bundles in axon maintenance and pathology ', Neural Development, vol. 14, no. 11, 10.1186/s13064-019-0134-0 . https://doi.org/10.1186/s13064-019-0134-0
Neural Development
Hahn, I, Voelzmann, A, Liew, Y T, Costa Gomes, B & Prokop, A 2019, ' The model of local axon homeostasis-explaining the role and regulation of microtubule bundles in axon maintenance and pathology ', Neural Development, vol. 14, no. 11, 10.1186/s13064-019-0134-0 . https://doi.org/10.1186/s13064-019-0134-0
Axons are the slender, cable-like, up to meter-long projections of neurons that electrically wire our brains and bodies. In spite of their challenging morphology, they usually need to be maintained for an organism's lifetime. This makes them key lesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3888fa799dc945b2f630712a614cef51
http://link.springer.com/article/10.1186/s13064-019-0134-0
http://link.springer.com/article/10.1186/s13064-019-0134-0
Autor:
Anna L. Munro, Ines Hahn, Ryan J. H. West, Stuart Pickering-Brown, Richard A. Baines, Joanne L. Sharpe, André Voelzmann
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Hahn, I, Sharpe, J, Voelzmann, A, Munro, A, Baines, R, Pickering-Brown, S & West, R 2020, ' Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age-and combination-specific phenotypic profiles in Drosophila ', Acta Neuropathologica Communications, vol. 8, no. 158 . https://doi.org/10.1186/s40478-020-01028-y
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Hahn, I, Sharpe, J, Voelzmann, A, Munro, A, Baines, R, Pickering-Brown, S & West, R 2020, ' Co-expression of C9orf72 related dipeptide-repeats over 1000 repeat units reveals age-and combination-specific phenotypic profiles in Drosophila ', Acta Neuropathologica Communications, vol. 8, no. 158 . https://doi.org/10.1186/s40478-020-01028-y
A large intronic hexanucleotide repeat expansion (GGGGCC) within the C9orf72 (C9orf72-SMCR8 Complex Subunit) locus is the most prevalent genetic cause of both Frontotemporal Dementia (FTD) and Motor Neuron Disease (MND). In patients this expansion is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d42ac9e36c8afe30209b02288df1ed
http://europepmc.org/articles/PMC7487709
http://europepmc.org/articles/PMC7487709
Publikováno v:
Molecular Biology of the Cell
Qu, Y, Hahn, I, Webb, S, Pearce, S & Prokop, A 2017, ' Periodic actin structures in neuronal axons are required to maintain microtubules ', Molecular Biology of the Cell, vol. 28, no. 296-308, mbc.E16-10-0727, pp. 296-308 . https://doi.org/10.1091/mbc.E16-10-0727
Qu, Y, Hahn, I, Webb, S, Pearce, S & Prokop, A 2017, ' Periodic actin structures in neuronal axons are required to maintain microtubules ', Molecular Biology of the Cell, vol. 28, no. 296-308, mbc.E16-10-0727, pp. 296-308 . https://doi.org/10.1091/mbc.E16-10-0727
Drosophila genetics is combined with high-resolution microscopy and a number of functional readouts to demonstrate key factors required for the presence of regularly spaced rings of cortical actin in axons. The data suggest important roles for the ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9bc726e77ae0d89c2df7d95dfbea16
https://doi.org/10.1091/mbc.e16-10-0727
https://doi.org/10.1091/mbc.e16-10-0727