Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ines H. Kaltheuner"'
Autor:
Ines H. Kaltheuner, Kanchan Anand, Jonas Moecking, Robert Düster, Jinhua Wang, Nathanael S. Gray, Matthias Geyer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Abemaciclib is a third generation CDK-directed drug used in the treatment of HR + /HER2 negative advanced or metastatic breast cancer. Here the authors demonstrate that members of the Homeodomain-interacting protein kinases (HIPKs) HIPK3 and DYRK1A a
Externí odkaz:
https://doaj.org/article/33e83e6764fc43a883e68121456aa437
Autor:
Kevin Baßler, Wataru Fujii, Theodore S. Kapellos, Erika Dudkin, Nico Reusch, Ari Horne, Benedikt Reiz, Malte D. Luecken, Collins Osei-Sarpong, Stefanie Warnat-Herresthal, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Allon Wagner, Patrick Günther, Carmen Pizarro, Tina Schreiber, Rainer Knoll, Lisa Holsten, Charlotte Kröger, Elena De Domenico, Matthias Becker, Kristian Händler, Christian T. Wohnhaas, Florian Baumgartner, Meike Köhler, Heidi Theis, Michael Kraut, Marc H. Wadsworth, Travis K. Hughes, Humberto J. Ferreira, Emily Hinkley, Ines H. Kaltheuner, Matthias Geyer, Christoph Thiele, Alex K. Shalek, Andreas Feißt, Daniel Thomas, Henning Dickten, Marc Beyer, Patrick Baum, Nir Yosef, Anna C. Aschenbrenner, Thomas Ulas, Jan Hasenauer, Fabian J. Theis, Dirk Skowasch, Joachim L. Schultze
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive pulmonary disease (COPD) are far from being understood. Here, we determine disease-related changes in cellular and molecular compositions within the alveolar sp
Externí odkaz:
https://doaj.org/article/e0f1f3d9372546f1a11d2fa5f19b33eb
Autor:
Megan L. Insco, Brian J. Abraham, Sara J. Dubbury, Ines H. Kaltheuner, Sofia Dust, Constance Wu, Kevin Y. Chen, David Liu, Stanislav Bellaousov, Anna M. Cox, Benjamin J. E. Martin, Tongwu Zhang, Calvin G. Ludwig, Tania Fabo, Rodsy Modhurima, Dakarai E. Esgdaille, Telmo Henriques, Kevin M. Brown, Stephen J. Chanock, Matthias Geyer, Karen Adelman, Phillip A. Sharp, Richard A. Young, Paul L. Boutz, Leonard I. Zon
Publikováno v:
Science
RNA surveillance pathways detect and degrade defective transcripts to ensure RNA fidelity. We found that disrupted nuclear RNA surveillance is oncogenic. Cyclin-dependent kinase 13 ( CDK13 ) is mutated in melanoma, and patient-mutated CDK13 accelerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a0b2b1bcb20159e50e884d8f56a8dd
https://doi.org/10.1126/science.abn7625
https://doi.org/10.1126/science.abn7625
Autor:
Lea-Marie Jenster, Karl-Elmar Lange, Sabine Normann, Anja vom Hemdt, Jennifer D. Wuerth, Lisa D.J. Schiffelers, Yonas M. Tesfamariam, Florian N. Gohr, Laura Klein, Ines H. Kaltheuner, Stefan Ebner, Dorothee J. Lapp, Jacob Mayer, Jonas Moecking, Hidde L. Ploegh, Eicke Latz, Felix Meissner, Matthias Geyer, Beate M. Kümmerer, Florian I. Schmidt
Publikováno v:
Journal of Experimental Medicine. 220
Inflammasomes integrate cytosolic evidence of infection or damage to mount inflammatory responses. The inflammasome sensor NLRP1 is expressed in human keratinocytes and coordinates inflammation in the skin. We found that diverse stress signals induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b268466639bc0c9a69a6f4e077cca158
https://doi.org/10.1084/jem.20220837
https://doi.org/10.1084/jem.20220837
Autor:
Mikolaj Slabicki, Katja Blumenstock, Per Hoffmann, Marius Jentzsch, Thomas S. Ebert, Maximilian Schmitz, Ofir Israeli, Markus M. Nöthen, Gero Wilbring, Manuel Döhla, Nina Ishorst, Julia Reinhardt, David Li, Nir Paran, Max L. Jacobs, Ines H. Kaltheuner, Eva C. Beins, Jonathan Strecker, Feng Zhang, Amir Ben-Shmuel, Ricarda Maria Schmithausen, Bärbel Lippke, David Feldman, Aliona Wöhler, Martin Exner, Esther Sib, Aviv Regev, Jana Liebing, Matthias Geyer, Brian Cleary, Jonathan L. Schmid-Burgk, Kerstin U. Ludwig, Ronja Hollstein, Wibke Rüdiger, Rhiannon K. Macrae, Shay Weiss, Jacob Borrajo, Lara M. Hochfeld, Michael Hölzel
Publikováno v:
Nature Biotechnology. 39:1556-1562
Frequent testing of large population groups combined with contact tracing and isolation measures will be crucial for containing Coronavirus Disease 2019 outbreaks. Here we present LAMP-Seq, a modified, highly scalable reverse transcription loop-media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eab4d05e5589e12877a0bedca8945adf
https://doi.org/10.1038/s41587-021-00966-9
https://doi.org/10.1038/s41587-021-00966-9
Autor:
Kerstin U. Ludwig, Ricarda M. Schmithausen, David Li, Max L. Jacobs, Ronja Hollstein, Katja Blumenstock, Jana Liebing, Mikołaj Słabicki, Amir Ben-Shmuel, Ofir Israeli, Shay Weiss, Thomas S. Ebert, Nir Paran, Wibke Rüdiger, Gero Wilbring, David Feldman, Bärbel Lippke, Nina Ishorst, Lara M. Hochfeld, Eva C. Beins, Ines H. Kaltheuner, Maximilian Schmitz, Aliona Wöhler, Manuel Döhla, Esther Sib, Marius Jentzsch, Eva-Maria C. Moench, Jacob D. Borrajo, Jonathan Strecker, Julia Reinhardt, Brian Cleary, Matthias Geyer, Michael Hölzel, Rhiannon Macrae, Markus M. Nöthen, Per Hoffmann, Martin Exner, Aviv Regev, Feng Zhang, Jonathan L. Schmid-Burgk
Publikováno v:
Nature Biotechnology. 40:1295-1295
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42e52afab7a9b2006c83af43bb90f7a8
https://doi.org/10.1038/s41587-022-01428-6
https://doi.org/10.1038/s41587-022-01428-6
Autor:
Kerstin U, Ludwig, Ricarda M, Schmithausen, David, Li, Max L, Jacobs, Ronja, Hollstein, Katja, Blumenstock, Jana, Liebing, Mikołaj, Słabicki, Amir, Ben-Shmuel, Ofir, Israeli, Shay, Weiss, Thomas S, Ebert, Nir, Paran, Wibke, Rüdiger, Gero, Wilbring, David, Feldman, Bärbel, Lippke, Nina, Ishorst, Lara M, Hochfeld, Eva C, Beins, Ines H, Kaltheuner, Maximilian, Schmitz, Aliona, Wöhler, Manuel, Döhla, Esther, Sib, Marius, Jentzsch, Eva-Maria C, Moench, Jacob D, Borrajo, Jonathan, Strecker, Julia, Reinhardt, Brian, Cleary, Matthias, Geyer, Michael, Hölzel, Rhiannon, Macrae, Markus M, Nöthen, Per, Hoffmann, Martin, Exner, Aviv, Regev, Feng, Zhang, Jonathan L, Schmid-Burgk
Publikováno v:
Nature biotechnology. 39(12)
Frequent testing of large population groups combined with contact tracing and isolation measures will be crucial for containing Coronavirus Disease 2019 outbreaks. Here we present LAMP-Seq, a modified, highly scalable reverse transcription loop-media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ccf6f7297617246bb589898e046580d1
https://pubmed.ncbi.nlm.nih.gov/35851378
https://pubmed.ncbi.nlm.nih.gov/35851378
Publikováno v:
The Journal of Biological Chemistry
The concept of liquid–liquid phase separation (LLPS) has emerged as an intriguing mechanism for the organization of membraneless compartments in cells. The alcohol 1,6-hexanediol is widely used as a control to dissolve LLPS assemblies in phase sepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7969621984bc4a26a43efd29a43fdb29
https://pubmed.ncbi.nlm.nih.gov/33814344
https://pubmed.ncbi.nlm.nih.gov/33814344
Autor:
Goran Malojčić, Martine Brault, Ines H. Kaltheuner, Lewis C. Cantley, Patrick Deroy, Heeyoun Bunch, Shanhu Hu, Janet Iwasa, Robin D. Dowell, Michael J. Bradley, Christian Clavette, Limei Tao, Peter W. White, Matthias Geyer, Zachary C. Poss, William M. Old, Zachary L. Maas, Shraddha Nayak, Tim-Michael Decker, Christopher C. Ebmeier, Benjamin Erickson, Leah J. Damon, David Bentley, Jenna K. Rimel, Tomer M. Yaron, Jason J. Marineau, Jared L. Johnson, Kristin B. Hamman, Dylan J. Taatjes
Publikováno v:
Genes Dev
CDK7 associates with the 10-subunit TFIIH complex and regulates transcription by phosphorylating the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Few additional CDK7 substrates are known. Here, using the covalent inhibitor SY-351 and quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec82b692d03b26dca0e48986e06f8ae7
https://pubmed.ncbi.nlm.nih.gov/33060135
https://pubmed.ncbi.nlm.nih.gov/33060135
Autor:
Matthias Geyer, Jie Jiang, Ines H. Kaltheuner, Danette L. Daniels, Yang Gao, Nathanael S. Gray, Tinghu Zhang, Inchul You, Ruben Dries, Marian Kalocsay, Jianwei Che, Wenchao Lu, Peter K. Sorger, Kristin M. Riching, Nicholas Kwiatkowski, Baishan Jiang, Matthew J. Berberich
Publikováno v:
Nat Chem Biol
Cyclin-dependent kinase 12 (CDK12) is an emerging therapeutic target due to its role in regulating transcription of DNA-damage response (DDR) genes. However, development of selective small molecules targeting CDK12 has been challenging due to the hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5070e1fa3774a3049269c26c90be530
https://pubmed.ncbi.nlm.nih.gov/33753926
https://pubmed.ncbi.nlm.nih.gov/33753926