Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ines G. Muñoz"'
Autor:
Marta Compte, Seandean Lykke Harwood, Ines G. Muñoz, Rocio Navarro, Manuela Zonca, Gema Perez-Chacon, Ainhoa Erce-Llamazares, Nekane Merino, Antonio Tapia-Galisteo, Angel M. Cuesta, Kasper Mikkelsen, Eduardo Caleiras, Natalia Nuñez-Prado, M. Angela Aznar, Simon Lykkemark, Jorge Martínez-Torrecuadrada, Ignacio Melero, Francisco J. Blanco, Jorge Bernardino de la Serna, Juan M. Zapata, Laura Sanz, Luis Alvarez-Vallina
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Cancer therapy using systemically administrated 4-1BB-targeting antibodies is often associated with severe toxicity due to the nonspecific activation of autoreactive T cells. Here, the authors have developed a trimeric antibody targeting both 4-1BB a
Externí odkaz:
https://doaj.org/article/7575acc4586f44568954b0510de1f6d3
Autor:
Luis Alvarez-Vallina, Laura Sanz, Luis Paz-Ares, José L. Rodriguez-Peralto, Ignacio Melero, Ines G. Muñoz, Miguel A. Morcillo, Francisco J. Blanco, Angel Ramírez-Fernández, Manuela Zonca, Carmen Domínguez-Alonso, Oana Hangiu, Daniel Nehme-Álvarez, Nekane Merino, Marta Oteo, Belén Blanco, Maria C. Ochoa, Ana B. Enguita, Eva M. Garrido-Martin, Irene Ferrer, Eduardo Romero, Antonio Tapia-Galisteo, Ainhoa Erce-Llamazares, Seandean L. Harwood, Marta Compte
Structural and functional characterization of 4-1BBN/CEGFR after conjugation with p-SCN-Bn-deferoxamine (Df).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3945f0c7eb0bace17584c12704fcea
https://doi.org/10.1158/1078-0432.22479489.v1
https://doi.org/10.1158/1078-0432.22479489.v1
Autor:
Luis Alvarez-Vallina, Laura Sanz, Luis Paz-Ares, José L. Rodriguez-Peralto, Ignacio Melero, Ines G. Muñoz, Miguel A. Morcillo, Francisco J. Blanco, Angel Ramírez-Fernández, Manuela Zonca, Carmen Domínguez-Alonso, Oana Hangiu, Daniel Nehme-Álvarez, Nekane Merino, Marta Oteo, Belén Blanco, Maria C. Ochoa, Ana B. Enguita, Eva M. Garrido-Martin, Irene Ferrer, Eduardo Romero, Antonio Tapia-Galisteo, Ainhoa Erce-Llamazares, Seandean L. Harwood, Marta Compte
Oligonucleotides used in this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec019f0e79b48b5fb2d166260477d5fb
https://doi.org/10.1158/1078-0432.22479450
https://doi.org/10.1158/1078-0432.22479450
Autor:
Luis Alvarez-Vallina, Laura Sanz, Luis Paz-Ares, José L. Rodriguez-Peralto, Ignacio Melero, Ines G. Muñoz, Miguel A. Morcillo, Francisco J. Blanco, Angel Ramírez-Fernández, Manuela Zonca, Carmen Domínguez-Alonso, Oana Hangiu, Daniel Nehme-Álvarez, Nekane Merino, Marta Oteo, Belén Blanco, Maria C. Ochoa, Ana B. Enguita, Eva M. Garrido-Martin, Irene Ferrer, Eduardo Romero, Antonio Tapia-Galisteo, Ainhoa Erce-Llamazares, Seandean L. Harwood, Marta Compte
Purpose:The induction of 4-1BB signaling by agonistic antibodies can drive the activation and proliferation of effector T cells and thereby enhance a T-cell–mediated antitumor response. Systemic administration of anti-4-1BB–agonistic IgGs, althou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0301e39e8aab5729f7e31404cf8e54a9
https://doi.org/10.1158/1078-0432.c.6530226
https://doi.org/10.1158/1078-0432.c.6530226
Autor:
Hipólito Nicolás Cuesta-Hernández, Julia Contreras, Pablo Soriano-Maldonado, Jana Sánchez-Wandelmer, Wayland Yeung, Ana Martín-Hurtado, Inés G. Muñoz, Natarajan Kannan, Marta Llimargas, Javier Muñoz, Iván Plaza-Menacho
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Autophosphorylation controls the transition between discrete functional and conformational states in protein kinases, yet the structural and molecular determinants underlying this fundamental process remain unclear. Here we show that c-termi
Externí odkaz:
https://doaj.org/article/c3b166424ee543e296abfd732eab6d76
Autor:
Pilar Mur, Julen Viana-Errasti, Sandra García-Mulero, Lorena Magraner-Pardo, Inés G. Muñoz, Tirso Pons, Gabriel Capellá, Marta Pineda, Lidia Feliubadaló, Laura Valle
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background Germline variants affecting the proofreading activity of polymerases epsilon and delta cause a hereditary cancer and adenomatous polyposis syndrome characterized by tumors with a high mutational burden and a specific mutational sp
Externí odkaz:
https://doaj.org/article/0d8eedbedf5a4275aa0193c67a801de8
Autor:
Rodrigo Lázaro‐Gorines, Patricia Pérez, Ignacio Heras‐Murillo, Irene Adán‐Barrientos, Guillermo Albericio, David Astorgano, Sara Flores, Joanna Luczkowiak, Nuria Labiod, Seandean L. Harwood, Alejandro Segura‐Tudela, Laura Rubio‐Pérez, Yudhi Nugraha, Xiaoran Shang, Yuxing Li, Carlos Alfonso, Kaylin A. Adipietro, Dinendra L. Abeyawardhane, Rocío Navarro, Marta Compte, Wenbo Yu, Alexander D. MacKerell Jr, Laura Sanz, David J. Weber, Francisco J. Blanco, Mariano Esteban, Edwin Pozharski, Raquel Godoy‐Ruiz, Inés G. Muñoz, Rafael Delgado, David Sancho, Juan García‐Arriaza, Luis Álvarez‐Vallina
Publikováno v:
Advanced Science, Vol 10, Iss 34, Pp n/a-n/a (2023)
Abstract Administration of neutralizing antibodies (nAbs) has proved to be effective by providing immediate protection against SARS‐CoV‐2. However, dual strategies combining virus neutralization and immune response stimulation to enhance specific
Externí odkaz:
https://doaj.org/article/83ee823ecfc342e88a1c1efafa321622
This book provides a clear, comprehensible and up-to-date description of how Small Angle Scattering (SAS) can help structural biology researchers. SAS is an efficient technique that offers structural information on how biological macromolecules behav
Autor:
Siseth Martínez-Caballero, Céline Freton, Rafael Molina, Sergio G. Bartual, Virginie Gueguen-Chaignon, Chryslène Mercy, Federico Gago, Kiran V. Mahasenan, Inés G. Muñoz, Mijoon Lee, Dusan Hesek, Shahriar Mobashery, Juan A. Hermoso, Christophe Grangeasse
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112756- (2023)
Summary: Bacterial cell-wall hydrolases must be tightly regulated during bacterial cell division to prevent aberrant cell lysis and to allow final separation of viable daughter cells. In a multidisciplinary work, we disclose the molecular dialogue be
Externí odkaz:
https://doaj.org/article/d81c8fc5e2aa4f5d9ff7f86ec5f0dc25
Autor:
Rati Lama, Chao Xu, Samuel L. Galster, Javier Querol-García, Scott Portwood, Cory K. Mavis, Federico M. Ruiz, Diana Martin, Jin Wu, Marianna C. Giorgi, Jill Bargonetti, Eunice S. Wang, Francisco J. Hernandez-Ilizaliturri, Gerald B. Koudelka, Sherry R. Chemler, Inés G. Muñoz, Xinjiang Wang
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
MDM2 and MDM4 proteins are key negative regulators of tumor suppressor p53. MDM2 and MDM4 interact via their RING domains and form a heterodimer polyubiquitin E3 ligase essential for p53 degradation. MDM4 also forms heterodimer E3 ligases with MDM2 i
Externí odkaz:
https://doaj.org/article/ac45ea6ffa8a496fa654d17db6618c95