Smac mimetic sensitizes renal cell carcinoma cells to interferon-α-induced apoptosis

Autor: Michael Reiter, Simone Fulda, Axel Haferkamp, Ines Eckhardt

Publikováno v: Cancer Letters. 375:1-8

The prognosis of metastatic or relapsed renal cell carcinoma (RCC) is still very poor, highlighting the need for new treatment strategies. Here, we identify a cooperative antitumor activity of interferon-α (IFNα) together with the Smac mimetic BV6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10a76746d490359a05984441195dd52
https://doi.org/10.1016/j.canlet.2016.02.019

Smac mimetic promotes glioblastoma cancer stem-like cell differentiation by activating NF-κB

Autor: Claudia Jennewein, Aurélie Tchoghandjian, Dominique Figarella-Branger, Simone Fulda, Ines Eckhardt, Stefan Momma

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2014, 21 (5), pp.735-747. ⟨10.1038/cdd.2013.200⟩
Cell Death and Differentiation, 2014, 21 (5), pp.735-747. ⟨10.1038/cdd.2013.200⟩

International audience; Recently, a broader role of inhibitor of apoptosis (IAP) proteins besides their antiapoptotic functions has been described. Therefore, we investigated the effect of non-toxic concentrations of the small-molecule Smac mimetic B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a981ed3b54be87b0aaf1817d84ba4d0f
https://doi.org/10.1038/cdd.2013.200

ΔNp63 activates the Fanconi anemia DNA repair pathway and limits the efficacy of cisplatin treatment in squamous cell carcinoma

Autor: Anne Catherine, Bretz, Miriam P, Gittler, Joël P, Charles, Niklas, Gremke, Ines, Eckhardt, Marco, Mernberger, Robert, Mandic, Jürgen, Thomale, Andrea, Nist, Michael, Wanzel, Thorsten, Stiewe

Publikováno v: Nucleic Acids Research

TP63, a member of the p53 gene family gene, encodes the ΔNp63 protein and is one of the most frequently amplified genes in squamous cell carcinomas (SCC) of the head and neck (HNSCC) and lungs (LUSC). Using an epiallelic series of siRNAs with intrin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fec5f33f4f07a2c17f78601f80c72b70
https://pubmed.ncbi.nlm.nih.gov/26819410

Identification of non-canonical NF-κB signaling as a critical mediator of Smac mimetic-stimulated migration and invasion of glioblastoma

Autor: Claudia Jennewein, K Rajalingam, Simone Fulda, Ines Eckhardt, Aurélie Tchoghandjian

Publikováno v: Klinische Pädiatrie. 225

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55e6c06857806e5cc3892a04c282740c
https://doi.org/10.1055/s-0033-1353461

The acid-sensitive potassium channel TASK-1 in rat cardiac muscle

Autor: Konstantin Wemhöner, Xian Tao Li, Regina Preisig-Müller, C. Putzke, Erhard Wischmeyer, Ines Eckhardt, Lucas T. Jae, Susanne Rinné, Niels Decher, Hinnerk Wulf, Frank B. Sachse, Günter Schlichthörl, Jürgen Daut

Publikováno v: Cardiovascular research. 75(1)

Objective: The outward current flowing through the two-pore domain acid-sensitive potassium channel TASK-1 (ITASK) and its inhibition via α1-adrenergic receptors was studied in rat ventricular cardiomyocytes. Methods: Quantitative RT-PCR experiments

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6379e1dfd4c2f9e4cf153b7edcf37f
https://pubmed.ncbi.nlm.nih.gov/17531212