Olfactory neuroblastoma in children and adolescents: The EXPeRT recommendations for diagnosis and management

Autor: Daniela Di Carlo, Giulia Fichera, Benoit Dumont, Enrico Pozzo, Beate Timmermann, Romain Luscan, Antoine Moya-Plana, Anna Synakiewicz, Ewa Bien, Nino Jorge dos Reis Farinha, Malgorzata Krawczyk, Rita Alaggio, Apostolos Pourtsidis, Brice Fresneau, Yves Reguerre, Tal Ben-Ami, Calogero Virgone, Jelena Roganovic, Jan Godzinski, Ines B Brecht, Dominik Schneider, Andrea Ferrari, Barbara Hero, Daniel Orbach, Gianni Bisogno

Publikováno v: EJC Paediatric Oncology, Vol 3, Iss , Pp 100136- (2024)

Olfactory neuroblastoma (ON) is a rare tumor commonly presenting between 50 and 60 years of age. In pediatric age this tumor is even rarer, with an estimated incidence of 0.1 per 100,000 children up to 15 years. It arises from the olfactory neurorepi

Externí odkaz: https://doaj.org/article/63347801e0a243b0bc1bc645d4cb7d88

UV-radiation and MC1R germline mutations are risk factors for the development of conventional and spitzoid melanomas in children and adolescentsResearch in context

Autor: Alexandra Liebmann, Jakob Admard, Sorin Armeanu-Ebinger, Hannah Wild, Michael Abele, Axel Gschwind, Olga Seibel-Kelemen, Christian Seitz, Irina Bonzheim, Olaf Riess, German Demidov, Marc Sturm, Malou Schadeck, Michaela Pogoda, Ewa Bien, Malgorzata Krawczyk, Eva Jüttner, Thomas Mentzel, Maja Cesen, Elke Pfaff, Michal Kunc, Stephan Forchhammer, Andrea Forschner, Ulrike Leiter-Stöppke, Thomas K. Eigentler, Dominik T. Schneider, Christopher Schroeder, Stephan Ossowski, Ines B. Brecht

Publikováno v: EBioMedicine, Vol 96, Iss , Pp 104797- (2023)

Summary: Background: Genomic characterisation has led to an improved understanding of adult melanoma. However, the aetiology of melanoma in children is still unclear and identifying the correct diagnosis and therapeutic strategies remains challenging

Externí odkaz: https://doaj.org/article/127dec53e6d3434d85e40f46cbf6798e

The genomic landscape of pediatric renal cell carcinomas

Autor: Pengbo Beck, Barbara Selle, Lukas Madenach, David T.W. Jones, Christian Vokuhl, Apurva Gopisetty, Arash Nabbi, Ines B. Brecht, Martin Ebinger, Jenny Wegert, Norbert Graf, Manfred Gessler, Stefan M. Pfister, Natalie Jäger

Publikováno v: iScience, Vol 25, Iss 4, Pp 104167- (2022)

Summary: Pediatric renal cell carcinomas (RCC) differ from their adult counterparts not only in histologic subtypes but also in clinical characteristics and outcome. However, the underlying biology is still largely unclear. For this reason, we perfor

Externí odkaz: https://doaj.org/article/92c8d7472b5b4a918676c0c8fb0e0805

Data from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

Autor: Olaf Witt, Stefan M. Pfister, David Capper, Jan J. Molenaar, David T.W. Jones, Annette Kopp-Schneider, Peter Lichter, Ruth Witt, Angelika Freitag, Uta Dirksen, Andreas von Deimling, Felix Sahm, David Reuss, Stephan Wolf, Natalie Jäger, Till Milde, C. Michel Zwaan, Bianca Goemans, Maria Filippidou, Antonis Kattamis, Bernarda Kazanowska, Olli Lohi, Nicolas U. Gerber, Caroline Hutter, Ingrid Øra, Roman Tremmel, Matthias Schwab, Simone Hettmer, Monika Scheer, Michael T. Meister, Ewa Koscielniak, Simone Fulda, Petra Ketteler, Ines B. Brecht, Dominik T. Schneider, Michael C. Frühwald, Stefanie Hecker-Nolting, Michaela Nathrath, Wilhelm Wößmann, Birgit Burkhardt, Angelika Eggert, Matthias Fischer, Frank Westermann, Norbert Graf, Peter Vorwerk, Gabriele Calaminus, André O. von Bueren, Christof M. Kramm, Irene Schmid, Dietrich von Schweinitz, Stephan Tippelt, Gudrun Fleischhack, Jan-Henning Klusmann, Dirk Reinhardt, Roland Meisel, Arndt Borkhardt, Andrej Lissat, Andreas E. Kulozik, Arend von Stackelberg, Kerstin Grund, Christian Sutter, Steffen Hirsch, Nicola Dikow, Kathrin Schramm, Mirjam Blattner-Johnson, Pascal D. Johann, Sebastian Stark, Gnana Prakash Balasubramanian, Barbara C. Jones, Petra Fiesel, Karin P.S. Langenberg, Kristian W. Pajtler, Elke Pfaff, Cornelis M. van Tilburg

INFORM is a prospective, multinational registry gathering clinical and molecular data of relapsed, progressive, or high-risk pediatric patients with cancer. This report describes long-term follow-up of 519 patients in whom molecular alterations were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff21fae7f2dbec73c8ce658d2e5de67
https://doi.org/10.1158/2159-8290.c.6549356.v1

Supplementary Figure from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

Autor: Olaf Witt, Stefan M. Pfister, David Capper, Jan J. Molenaar, David T.W. Jones, Annette Kopp-Schneider, Peter Lichter, Ruth Witt, Angelika Freitag, Uta Dirksen, Andreas von Deimling, Felix Sahm, David Reuss, Stephan Wolf, Natalie Jäger, Till Milde, C. Michel Zwaan, Bianca Goemans, Maria Filippidou, Antonis Kattamis, Bernarda Kazanowska, Olli Lohi, Nicolas U. Gerber, Caroline Hutter, Ingrid Øra, Roman Tremmel, Matthias Schwab, Simone Hettmer, Monika Scheer, Michael T. Meister, Ewa Koscielniak, Simone Fulda, Petra Ketteler, Ines B. Brecht, Dominik T. Schneider, Michael C. Frühwald, Stefanie Hecker-Nolting, Michaela Nathrath, Wilhelm Wößmann, Birgit Burkhardt, Angelika Eggert, Matthias Fischer, Frank Westermann, Norbert Graf, Peter Vorwerk, Gabriele Calaminus, André O. von Bueren, Christof M. Kramm, Irene Schmid, Dietrich von Schweinitz, Stephan Tippelt, Gudrun Fleischhack, Jan-Henning Klusmann, Dirk Reinhardt, Roland Meisel, Arndt Borkhardt, Andrej Lissat, Andreas E. Kulozik, Arend von Stackelberg, Kerstin Grund, Christian Sutter, Steffen Hirsch, Nicola Dikow, Kathrin Schramm, Mirjam Blattner-Johnson, Pascal D. Johann, Sebastian Stark, Gnana Prakash Balasubramanian, Barbara C. Jones, Petra Fiesel, Karin P.S. Langenberg, Kristian W. Pajtler, Elke Pfaff, Cornelis M. van Tilburg

Supplementary Figure from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87241d6487fda7eea0b9f69782d2a059
https://doi.org/10.1158/2159-8290.22540361.v1