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Relationship BetweenSDF-1G801APolymorphism and its Expression in Tunisian Patients with Colorectal Cancer

Autor: Abdelmajid Ben Hmida, Sabeh Mzabi, Saadia Bouraoui, Sameh Amara, Donia Ounissi, Meriem Khiari, Ines Chaar

Publikováno v: Journal of Immunoassay and Immunochemistry. 36:182-194

The aim was to evaluate the relationship between SDF-1G801A polymorphism and its immunohistochemical expression in colorectal cancer tissues in the Tunisian cohort. The molecular and immunohistochemical analysis showed that SDF-1G801A polymorphic var

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59eae2ff4d22a59d87406796dd049ed8
https://doi.org/10.1080/15321819.2014.917428

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Biological significance of promoter hypermethylation of p14/ARF gene: Relationships to p53 mutational status in Tunisian population with colorectal carcinoma

Autor: Taher Khalfallah, Saadia Bouraoui, Sameh Amara, Ines Chaar, Mariem Khiari, Sabeh Mzabi, Donia Ounissi, Olfa Elhadj Elamine, Abdelmajid Ben Hmida

Publikováno v: Tumour Biology

One of the most important pathways which are frequently affected in colorectal cancer is p53/ (MDM2)/p14ARF pathway. We aim to determine the methylation pattern of p14/ARF in relation to mutation of p53. This correlation was studied to investigate wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67231aefaa831851e519f264a7bc4985
https://doi.org/10.1007/s13277-013-1198-9

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Relationship Between MDM2 and p53 Alterations in Colorectal Cancer and Their Involvement and Prognostic Value in the Tunisian Population

Autor: Lassad Gharbi, Sameh Amara, Sabeh Mzabi, Mariem Khiari, Saadia Bouraoui, Monia Dhraif, Donia Ounissi, Ines Chaar, Abd E.M. Ben Hamida

Publikováno v: Applied Immunohistochemistry & Molecular Morphology. 21:228-236

BACKGROUND The prevalence of p53 mutations in colorectal cancer could reach 90%. The most important regulator of this protein that was identified originally was the Murine Double Minute2 (MDM2) oncoprotein, by which the levels of p53 were fixed throu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1abba4b4ed9022435a16d9e3962fb652
https://doi.org/10.1097/pai.0b013e31825f4e20

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Pure Micropapillary Carcinoma of the Male Breast: Report of A Rare Case

Autor: Ahmed El May, Ines Chaar, Olfa El Amine El Hadj, Aida Goucha, Maissa Belghith, Amor Gamoudi

Publikováno v: Breast Cancer: Current Research.

Objective: Breast carcinoma in men represents 1% of all breast cancers. The micropapillary carcinoma (MPC) of the breast is a morphologically distinctive form accounting for 2.7% of ductual carcinoma in which the tumor cells are arranged in morule-li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a06ad1b287861caeb044fcc1200130a
https://doi.org/10.4172/2572-4118.1000113

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The Prognostic Value of the Immunohistochemical Expression and Mutational Pattern of the Key Mediator of Wnt Signaling

Autor: Sameh Amara, Monia Dhraeif, Meriem Khiari, Sabeh Mzabi-Regaya, Med Amine Lounis, Arfaoui A, Saadia Bouraoui, Lassaad Gharbi, Souraya Sammoud, Lilia Kriaa, Ines Chaar

Publikováno v: Applied Immunohistochemistry & Molecular Morphology. 20:62-70

Beta-catenin plays a critical role with E-cadherin in cell-cell adhesion and is also a key molecule of the highly conserved Wnt signaling pathway that regulates cell proliferation and differentiation. Abrogation of this pathway is implicated in the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27e9a3f8b7aa4b7d1ff992ea17c16cd
https://doi.org/10.1097/pai.0b013e31821a20c2

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Relationship Between p73 Polymorphism and the Immunohistochemical Profile of the Full-length (TAp73) and NH2-truncated (ΔNp73) Isoforms in Tunisian Patients

Autor: Sabeh Mzabi Regaya, Amine Lounis Mohamed, Taher Khalfallah, Abdelmajid Ben Hmida, Saadia Bouraoui, Ines Chaar, Lilia Kriaa Ben Mahmoud, Amira Toumi Arfaoui, Mariem Khiari

Publikováno v: Applied Immunohistochemistry & Molecular Morphology. 18:546-554

Background We examined the association of one linked GC/AT polymorphism at p73 with the risk of colorectal cancer. Aim In this study, we investigated whether this polymorphism was related to the risk of colorectal cancer, and whether there were relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56101b6b06c93d6b8f870782e3f34c40
https://doi.org/10.1097/pai.0b013e3181e9fe58

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Evaluation of microsatellite instability, MLH1 expression and hMLH1 promoter hypermethylation in colorectal carcinomas among Tunisians patients

Autor: Lilia, Kria Ben Mahmoud, Amira, Arfaoui, Mariem, Khiari, Ines, Chaar, Amine, Lounis, Souraya, Sammoud, Abdel Majid, Ben Hmida, Lasaad, Gharbi, Sabeh Regaya, Mzabi, Saadia, Bouraoui

Publikováno v: La Tunisie medicale. 90(8-9)

About 10% to 15% of sporadic colorectal cancers demonstrate high level of microsatellite instability that is generally associated with aberrant methylation of hMLH1 promoter.To investigate the association between MSI status, hMLH1 protein expression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::372f527afb758015ff8ea7211f2e9fc0
https://pubmed.ncbi.nlm.nih.gov/22987381

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Impact of MDM2 polymorphism: increased risk of developing colorectal cancer and a poor prognosis in the Tunisian population

Autor: Semeh Amara, Toumi Amira Arfaoui, Soraya Sammoud, El Hadj Olfa El Amine, Lassad Gharbi, Saadia Bouraoui, Ines Chaar, Sabeh Mzabi, Abdelmajid Ben Hmida, Amine Lounis, Lilia Kria Ben Mahmoud, Mariem Khiari

Publikováno v: European journal of gastroenterologyhepatology. 24(3)

MDM2 was originally identified as an oncoprotein that binds to p53 and inhibits p53-mediated transactivation. Scientists have described functional single-nucleotide polymorphisms (SNP) in the MDM2 gene. They showed that the genotype of SNP 309 induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d766c0bf41f357203408f9dc78b44e8
https://pubmed.ncbi.nlm.nih.gov/22266832

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