Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ineke van Wijngaarden"'
Publikováno v:
Medicinal Research Reviews. 25:398-426
It has been recently established that G-protein-coupled receptors (GPCRs) can be constitutively active, i.e., they can be active in the absence of an agonist. This activity can be inhibited by so-called inverse agonists. For a number of GPCRs, such i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76ecad2a935de9b88bde7029b4b6c9b
https://doi.org/10.1002/med.20031
https://doi.org/10.1002/med.20031
Publikováno v:
Drug Discovery Today. 9:752-758
Allosteric modulation of G protein-coupled receptors has recently been recognized as an alternative approach to gain selectivity in drug action. In this overview, allosteric modulators that enhance or diminish the effects of (endogenous) agonists or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9ffaeee0aef69b1637a13cbd5b5a18
https://doi.org/10.1016/s1359-6446(04)03220-9
https://doi.org/10.1016/s1359-6446(04)03220-9
Publikováno v:
Current Topics in Medicinal Chemistry. 3:355-367
In this review the latest developments in ligand design for the adenosine A(1) receptor are summarized. Novel series of agonists and antagonists are discussed, leading to the conclusion that ligands truly selective for the human adenosine A(1) recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a1aa61cd15d3ceb95acaa7dc0b9217
https://doi.org/10.2174/1568026033392165
https://doi.org/10.2174/1568026033392165
Synthesis and biological evaluation of lorglumide-like hybrid cholecystokinin-A receptor antagonists
Autor:
Ineke Van Wijngaarden, Willem Soudijn, Ingrid van den Brink, Arie van der Bent, Adriaan P. IJzerman
Publikováno v:
Drug Development Research. 31:197-205
The evaluation of gross structural homologies between the competitive cholecystokinin-A (CCK-A) receptor antagonists lorglumide and devazepide formerly enabled the development of compact hybrid analogues [Van der Bent et al. (1992): J Med Chem 35:104
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d64185e509c67f9a7fc5d9488ae379f
https://doi.org/10.1002/ddr.430310307
https://doi.org/10.1002/ddr.430310307
Publikováno v:
ChemInform. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c5d5207dce5ac0588912d169c5ced1f
https://doi.org/10.1002/chin.200541290
https://doi.org/10.1002/chin.200541290
Publikováno v:
IDrugs : the investigational drugs journal. 6(1)
Stereochemical aspects of drug action have intrigued researchers ever since (and even before) the introduction of the receptor concept. Easson and Stedman first formalized this by suggesting the three-point tethering of an asymmetric ligand to its ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6af458476aee819458898b786793ce4c
https://pubmed.ncbi.nlm.nih.gov/12789621
https://pubmed.ncbi.nlm.nih.gov/12789621
Publikováno v:
Current opinion in drug discoverydevelopment. 5(5)
Allosteric modulation of G-protein-coupled receptors may provide an alternative approach for selective receptor interactions. The article is an overview of allosteric modulators enhancing or diminishing the effects of (endogenous) agonists or antagon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9fbb3776ed3a4d30646e5798e063710
https://pubmed.ncbi.nlm.nih.gov/12630295
https://pubmed.ncbi.nlm.nih.gov/12630295
Autor:
Bijoy Kundu, Sanjay K. Khare, Vishnu Ji Ram, Atul Goel, Berend Olivier, Willem Soudijn, Ineke van Wijngaarden, Jacob Szmuszkovicz, Q. May Wang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7202417f641e1da2856a12ddaf07379
https://doi.org/10.1007/978-3-0348-8730-4
https://doi.org/10.1007/978-3-0348-8730-4
