Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ineke Luijten"'
Autor:
Eleanor J. McKay, Ineke Luijten, Sophie Broadway-Stringer, Adrian Thomson, Xiong Weng, Katya Gehmlich, Gillian A. Gray, Robert K. Semple
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 6 (2024)
Externí odkaz:
https://doaj.org/article/b7b9c8048f974463b24729c9de672092
Autor:
Eleanor J. McKay, Ineke Luijten, Xiong Weng, Pablo B. Martinez de Morentin, Elvira De Frutos González, Zhanguo Gao, Mikhail G. Kolonin, Lora K. Heisler, Robert K. Semple
Publikováno v:
Molecular Metabolism, Vol 84, Iss , Pp 101933- (2024)
Objective: Alström Syndrome (AS), caused by biallelic ALMS1 mutations, includes obesity with disproportionately severe insulin resistant diabetes, dyslipidemia, and fatty liver. Prior studies suggest that hyperphagia is accounted for by loss of ALMS
Externí odkaz:
https://doaj.org/article/6169fc3899214b92ba7975f834effd36
Autor:
Jake P Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Sam Virtue, Stephen O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage
Publikováno v:
eLife, Vol 12 (2023)
Mitochondrial dysfunction has been reported in obesity and insulin resistance, but primary genetic mitochondrial dysfunction is generally not associated with these, arguing against a straightforward causal relationship. A rare exception, recently ide
Externí odkaz:
https://doaj.org/article/10fcb30f48a744fd966e20290cf355fb
Autor:
Kanchan Phadwal, Qi-Yu Tang, Ineke Luijten, Jin-Feng Zhao, Brendan Corcoran, Robert K. Semple, Ian G. Ganley, Vicky E. MacRae
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1643 (2023)
Arterial calcification is an important characteristic of cardiovascular disease. It has key parallels with skeletal mineralization; however, the underlying cellular mechanisms responsible are not fully understood. Mitochondrial dynamics regulate both
Externí odkaz:
https://doaj.org/article/b99e971db0464787a2fe7e501279f7dc
Autor:
Albert Kwok, Ilona Zvetkova, Sam Virtue, Ineke Luijten, Isabel Huang-Doran, Patsy Tomlinson, David A. Bulger, James West, Steven Murfitt, Julian Griffin, Rafeah Alam, Daniel Hart, Rachel Knox, Peter Voshol, Antonio Vidal-Puig, Jørgen Jensen, Stephen O'Rahilly, Robert K. Semple
Publikováno v:
Molecular Metabolism, Vol 40, Iss , Pp 101020- (2020)
Objective: Insulin signalling via phosphoinositide 3-kinase (PI3K) requires PIK3R1-encoded regulatory subunits. C-terminal PIK3R1 mutations cause SHORT syndrome, as well as lipodystrophy and insulin resistance (IR), surprisingly without fatty liver o
Externí odkaz:
https://doaj.org/article/82f6d95279d840059ee0a0ab5c79af2b
Autor:
Jake P Mann, Xiaowen Duan, Satish Patel, Luis Carlos Tábara, Fabio Scurria, Anna Alvarez-Guaita, Afreen Haider, Ineke Luijten, Matthew Page, Margherita Protasoni, Koini Lim, Sam Virtue, Stephen O'Rahilly, Martin Armstrong, Julien Prudent, Robert K Semple, David B Savage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ce380063210e99c7c59b2837399d6d3
https://doi.org/10.7554/elife.82283.sa2
https://doi.org/10.7554/elife.82283.sa2
Autor:
Eleanor McKay, Ineke Luijten, Dominique McCormick, Adrian Thomson, Gillian Gray, Robert Semple
Publikováno v:
Endocrine Abstracts.
Autor:
Daniel Hart, Steven A. Murfitt, Albert Kwok, Patsy Tomlinson, David A Bulger, Antonio Vidal-Puig, Peter J. Voshol, Ineke Luijten, James A. West, Robert K. Semple, Julian L. Griffin, Jørgen Arendt Jensen, Samuel Virtue, Rachel G. Knox, Stephen O'Rahilly, Ilona Zvetkova, Rafeah Alam, Isabel Huang-Doran
Publikováno v:
Molecular Metabolism, Vol 40, Iss, Pp 101020-(2020)
Molecular Metabolism
Kwok, A, Zvetkova, I, Virtue, S, Luijten, I, Huang-doran, I, Tomlinson, P, Bulger, D A, West, J, Murfitt, S, Griffin, J, Alam, R, Hart, D, Knox, R, Voshol, P, Vidal-puig, A, Jensen, J, O’rahilly, S & Semple, R K 2020, ' Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidemia by increased energy expenditure ', Molecular Metabolism, pp. 101020 . https://doi.org/10.1016/j.molmet.2020.101020
Molecular Metabolism
Kwok, A, Zvetkova, I, Virtue, S, Luijten, I, Huang-doran, I, Tomlinson, P, Bulger, D A, West, J, Murfitt, S, Griffin, J, Alam, R, Hart, D, Knox, R, Voshol, P, Vidal-puig, A, Jensen, J, O’rahilly, S & Semple, R K 2020, ' Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidemia by increased energy expenditure ', Molecular Metabolism, pp. 101020 . https://doi.org/10.1016/j.molmet.2020.101020
Objective Insulin signalling via phosphoinositide 3-kinase (PI3K) requires PIK3R1-encoded regulatory subunits. C-terminal PIK3R1 mutations cause SHORT syndrome, as well as lipodystrophy and insulin resistance (IR), surprisingly without fatty liver or