Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Indu S Ambudkar"'
Autor:
Vaishali N. Patel, Marit H. Aure, Sophie H. Choi, James R. Ball, Ethan D. Lane, Zhangjie Wang, Yongmei Xu, Changyu Zheng, Xibao Liu, Daniel Martin, Jillian Y. Pailin, Michaela Prochazkova, Ashok B. Kulkarni, Toin H. van Kuppevelt, Indu S. Ambudkar, Jian Liu, Matthew P. Hoffman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Heparan sulfate (HS) regulation of FGFR function, which is essential for salivary gland (SG) development, is determined by the immense structural diversity of sulfated HS domains. 3-O-sulfotransferases generate highly 3-O-sulfated HS domains
Externí odkaz:
https://doaj.org/article/1d729c7a230d48a69e9967ba3a35489e
Autor:
Hongen Yin, Peter Kosa, Xibao Liu, William D Swaim, Zhennan Lai, Javier Cabrera-Perez, Giovanni Di Pasquale, Indu S Ambudkar, Thomas H Bugge, John A Chiorini
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e82852 (2014)
The objective of this study was to determine the effect of epithelial barrier disruption, caused by deficiency of the membrane-anchored serine protease, matriptase, on salivary gland function and the induction of autoimmunity in an animal model.Embry
Externí odkaz:
https://doaj.org/article/7da495799aa74d65b071f95ac9772e76
Autor:
Francesco Lodola, Umberto Laforenza, Elisa Bonetti, Dmitry Lim, Silvia Dragoni, Cinzia Bottino, Hwei Ling Ong, Germano Guerra, Carlo Ganini, Margherita Massa, Mariangela Manzoni, Indu S Ambudkar, Armando A Genazzani, Vittorio Rosti, Paolo Pedrazzoli, Franco Tanzi, Francesco Moccia, Camillo Porta
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e42541 (2012)
BACKGROUND:Endothelial progenitor cells (EPCs) may be recruited from bone marrow to sustain tumor vascularisation and promote the metastatic switch. Understanding the molecular mechanisms driving EPC proliferation and tubulogenesis could outline nove
Externí odkaz:
https://doaj.org/article/dcfe3702f9da4a0e822527ca6a64f5bb
Publikováno v:
PLoS Biology, Vol 9, Iss 3, p e1001025 (2011)
Store-operated Ca²+ entry (SOCE) has been associated with two types of channels: CRAC channels that require Orai1 and STIM1 and SOC channels that involve TRPC1, Orai1, and STIM1. While TRPC1 significantly contributes to SOCE and SOC channel activity
Externí odkaz:
https://doaj.org/article/64322283275949cf89a087ca6b28f5c3
Autor:
Krishna P. Subedi, Rajesh Bhardwaj, Indu S. Ambudkar, Hassan Saadi, Hwei Ling Ong, Changyu Zheng, Stefan Feske, Ga-Yeon Son, Lucile Noyer
Publikováno v:
Proceedings of the National Academy of Sciences. 117:16638-16648
The Orai1 channel is regulated by stromal interaction molecules STIM1 and STIM2 within endoplasmic reticulum (ER)-plasma membrane (PM) contact sites. Ca2+ signals generated by Orai1 activate Ca2+-dependent gene expression. When compared with STIM1, S
Autor:
Hwei Ling Ong, Lara E. Terry, Hassan Saadi, Mohamed Trebak, Zahra Shokatian, Ga-Yeon Son, Indu S. Ambudkar, Moaz Ahmad, David I. Yule
Stromal interaction molecules, STIM1 and STIM2, sense decreases in the endoplasmic reticulum (ER) [Ca2+] ([Ca2+]ER) and cluster in ER-plasma membrane (ER-PM) junctions where they recruit and activate Orai1. While STIM1 responds when [Ca2+]ER is relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30ecc3c76972e0bcedb46b2b0e9d1c8d
https://doi.org/10.1101/2021.09.24.461545
https://doi.org/10.1101/2021.09.24.461545
Autor:
Aldebaran M. Hofer, Indu S. Ambudkar
Publikováno v:
Curr Opin Physiol
Publikováno v:
Cell calcium. 99
Store-operated calcium entry (SOCE) is triggered by assembly of Orai1 with STIM proteins in ER-PM junctions. Plasma membrane PIP
Autor:
Hwei Ling Ong, William D. Swaim, Indu S. Ambudkar, Edismauro Garcia Freitas Filho, Constance Oliver, Maria Célia Jamur, Elaine Zayas Marcelino da Silva
Publikováno v:
J Cell Sci
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Although RACK1 is known to act as a signaling hub in immune cells, its presence and role in mast cells (MCs) is undetermined. MC activation via antigen stimulation results in mediator release and is preceded by cytoskeleton reorganization and Ca2+ mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab693090a89593204ee47d02e45d883
https://europepmc.org/articles/PMC8380048/
https://europepmc.org/articles/PMC8380048/
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1866:1037-1045
The intracellular calcium signaling processes are tightly regulated to ensure the generation of calcium signals with the specific spatiotemporal characteristics required for regulating various cell functions. Compartmentalization of the molecular com