Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Indu S Ambudkar"'
Autor:
Vaishali N. Patel, Marit H. Aure, Sophie H. Choi, James R. Ball, Ethan D. Lane, Zhangjie Wang, Yongmei Xu, Changyu Zheng, Xibao Liu, Daniel Martin, Jillian Y. Pailin, Michaela Prochazkova, Ashok B. Kulkarni, Toin H. van Kuppevelt, Indu S. Ambudkar, Jian Liu, Matthew P. Hoffman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Heparan sulfate (HS) regulation of FGFR function, which is essential for salivary gland (SG) development, is determined by the immense structural diversity of sulfated HS domains. 3-O-sulfotransferases generate highly 3-O-sulfated HS domains
Externí odkaz:
https://doaj.org/article/1d729c7a230d48a69e9967ba3a35489e
Autor:
Vaishali N. Patel, Marit H. Aure, Sophie H. Choi, James R. Ball, Ethan D. Lane, Zhangjie Wang, Yongmei Xu, Changyu Zheng, Xibao Liu, Daniel Martin, Jillian Y. Pailin, Michaela Prochazkova, Ashok B. Kulkarni, Toin H. van Kuppevelt, Indu S. Ambudkar, Jian Liu, Matthew P. Hoffman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/39016b373ef84ced8aa59dfb3ebcf038
Publikováno v:
Biomolecules, Vol 14, Iss 10, p 1200 (2024)
Calcium is an important second messenger that is involved in almost all cellular processes. Disruptions in the regulation of intracellular Ca2+ levels ([Ca2+]i) adversely impact normal physiological function and can contribute to various diseased con
Externí odkaz:
https://doaj.org/article/33b74f339def4ab49eeb2280bc528a69
Autor:
Krishna P. Subedi, Rajesh Bhardwaj, Indu S. Ambudkar, Hassan Saadi, Hwei Ling Ong, Changyu Zheng, Stefan Feske, Ga-Yeon Son, Lucile Noyer
Publikováno v:
Proceedings of the National Academy of Sciences. 117:16638-16648
The Orai1 channel is regulated by stromal interaction molecules STIM1 and STIM2 within endoplasmic reticulum (ER)-plasma membrane (PM) contact sites. Ca2+ signals generated by Orai1 activate Ca2+-dependent gene expression. When compared with STIM1, S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe97cf819c3acf3329c989aa1037a1e7
https://doi.org/10.1073/pnas.1915386117
https://doi.org/10.1073/pnas.1915386117
Autor:
Hwei Ling Ong, Lara E. Terry, Hassan Saadi, Mohamed Trebak, Zahra Shokatian, Ga-Yeon Son, Indu S. Ambudkar, Moaz Ahmad, David I. Yule
Stromal interaction molecules, STIM1 and STIM2, sense decreases in the endoplasmic reticulum (ER) [Ca2+] ([Ca2+]ER) and cluster in ER-plasma membrane (ER-PM) junctions where they recruit and activate Orai1. While STIM1 responds when [Ca2+]ER is relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30ecc3c76972e0bcedb46b2b0e9d1c8d
https://doi.org/10.1101/2021.09.24.461545
https://doi.org/10.1101/2021.09.24.461545
Autor:
Aldebaran M. Hofer, Indu S. Ambudkar
Publikováno v:
Curr Opin Physiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5add08892edd23963404fc29d132da8f
https://pubmed.ncbi.nlm.nih.gov/34532609
https://pubmed.ncbi.nlm.nih.gov/34532609
Publikováno v:
Cell calcium. 99
Store-operated calcium entry (SOCE) is triggered by assembly of Orai1 with STIM proteins in ER-PM junctions. Plasma membrane PIP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cf9c5f98b2d17b37db9cb7f7501db0e7
https://pubmed.ncbi.nlm.nih.gov/34601312
https://pubmed.ncbi.nlm.nih.gov/34601312
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1866:1037-1045
The intracellular calcium signaling processes are tightly regulated to ensure the generation of calcium signals with the specific spatiotemporal characteristics required for regulating various cell functions. Compartmentalization of the molecular com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87338b2beb5c218ed8c9053fe0bdc16e
https://doi.org/10.1016/j.bbamcr.2018.11.018
https://doi.org/10.1016/j.bbamcr.2018.11.018
Autor:
M Walker, Bradford Hall, Z.J. Sun, Ashok B. Kulkarni, Andrew Cho, F Adewusi, Changyu Zheng, Lina Zhang, John C. Dolan, Indu S. Ambudkar, Brian L. Schmidt, Peter D. Burbelo, Michaela Prochazkova, Advait Limaye
Publikováno v:
J Dent Res
Chronic inflammation of the salivary glands from pathologic conditions such as Sjögren’s syndrome can result in glandular destruction and hyposalivation. To understand which molecular factors may play a role in clinical cases of salivary gland hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521fd012bc09a8d8f988e4575382d691
https://doi.org/10.1177/0022034519837240
https://doi.org/10.1177/0022034519837240
Autor:
Hongen Yin, Peter Kosa, Xibao Liu, William D Swaim, Zhennan Lai, Javier Cabrera-Perez, Giovanni Di Pasquale, Indu S Ambudkar, Thomas H Bugge, John A Chiorini
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e82852 (2014)
The objective of this study was to determine the effect of epithelial barrier disruption, caused by deficiency of the membrane-anchored serine protease, matriptase, on salivary gland function and the induction of autoimmunity in an animal model.Embry
Externí odkaz:
https://doaj.org/article/7da495799aa74d65b071f95ac9772e76