Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Indu R. Chandrashekaran"'
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0283194 (2023)
Nsp9 is a conserved accessory component of the coronaviral replication and transcription complex. It is the predominant substrate of nsp12's nucleotidylation activity while also serving to recruit proteins required for viral 5'-capping. Anti-nsp9 spe
Externí odkaz:
https://doaj.org/article/36b3ed925aee42b396cb3271cf3e9250
Autor:
Rebecca L. Whitehouse, Wesam S. Alwan, Olga V. Ilyichova, Ashley J. Taylor, Indu R. Chandrashekaran, Biswaranjan Mohanty, Bradley C. Doak, Martin J. Scanlon
Publikováno v:
RSC Medicinal Chemistry. 14:135-143
Small molecule interaction hotpots were identified by screening small, low complexity fragments using X-ray crystallography. These hot spots include cryptic pockets and provide pharmacophore mapping that may be used in structure-based drug design.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f01b5b0acd10130a5231c58e2c9e5f0
https://doi.org/10.1039/d2md00253a
https://doi.org/10.1039/d2md00253a
Autor:
Anthony W. Purcell, Patricia T. Illing, Julie L. McAuley, Shea A. Lowery, Jamie Rossjohn, Damian F. J. Purcell, Indu R. Chandrashekaran, Benjamin S. Gully, Stanley Perlman, Dene R. Littler, Ronald J. Quinn, Miaomiao Liu
Publikováno v:
The Journal of Biological Chemistry
The Nsp9 replicase is a conserved coronaviral protein that acts as an essential accessory component of the multi-subunit viral replication/transcription complex. Nsp9 is the predominant substrate for the essential nucleotidylation activity of Nsp12.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3f93344530fb73ceb132edf1055995
https://pubmed.ncbi.nlm.nih.gov/34756886
https://pubmed.ncbi.nlm.nih.gov/34756886
Fatty acid binding proteins shape the cellular response to activation of the glucocorticoid receptor
Autor:
Stephan J, Melchiore F, Gosgnach W, Michelle L. Halls, Valour D, Indu R. Chandrashekaran, Genissel P, Porter Cj, Dacquet C, Bourrier C, Giganti A, O.V. Ilyichova, Bonan Liu, Weaver Rj, Martin J. Scanlon
Glucocorticoids are steroid hormones that are essential for life in mammals. Therapeutically, they are some of the most cost-effective drugs for the treatment of inflammatory diseases ranging from skin rashes to COVID-19, but their use is limited by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12235e336bac043e7a54c2bff87891bf
https://doi.org/10.1101/2021.07.02.450968
https://doi.org/10.1101/2021.07.02.450968
Autor:
Edmond M Linossi, Indu R Chandrashekaran, Tatiana B Kolesnik, James M Murphy, Andrew I Webb, Tracy A Willson, Lukasz Kedzierski, Alex N Bullock, Jeffrey J Babon, Raymond S Norton, Nicos A Nicola, Sandra E Nicholson
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70536 (2013)
Suppressor of Cytokine Signaling (SOCS)5 is thought to act as a tumour suppressor through negative regulation of JAK/STAT and epidermal growth factor (EGF) signaling. However, the mechanism/s by which SOCS5 acts on these two distinct pathways is uncl
Externí odkaz:
https://doaj.org/article/1bd4c33ee3a949f28850bca64c3e1c57
Publikováno v:
Molecules, Vol 21, Iss 7, p 860 (2016)
19F-NMR has proved to be a valuable tool in fragment-based drug discovery. Its applications include screening libraries of fluorinated fragments, assessing competition among elaborated fragments and identifying the binding poses of promising hits. By
Externí odkaz:
https://doaj.org/article/797583265b5f41d3909dd038926cd015
Publikováno v:
FEBS Letters. 592:179-189
Targeting the interaction between PKC isoforms and their anchoring proteins can specifically regulate kinase activity. εV1-2 and pseudoεRACK peptides, derived from the PKCε C2 domain, modulate its association with receptor for activated C-kinase 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ec6f880011930c5ee1dc539c5d9405
https://doi.org/10.1002/1873-3468.12953
https://doi.org/10.1002/1873-3468.12953
Autor:
Richard J. Weaver, Biswaranjan Mohanty, Michelle L. Halls, Patrick Genissel, Craig Steven Clements, Laurent Vuillard, Christopher J.H. Porter, Indu R. Chandrashekaran, Rahul Chandrakant Patil, Bradley C. Doak, Martin Williams, Stephen J. Headey, O.V. Ilyichova, Bonan Liu, Martin J. Scanlon
Peroxisome proliferator–activated receptor α (PPARα) is a transcriptional regulator of lipid metabolism. GW7647 is a potent PPARα agonist that must reach the nucleus to activate this receptor. In cells expressing human fatty acid–binding prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d0cd4ce2d9bfc97952bae843ac2ca7
https://europepmc.org/articles/PMC6416440/
https://europepmc.org/articles/PMC6416440/
Autor:
Allyn C. Howlett, Sudha M. Cowsik, Khalil Eldeeb, Indu R. Chandrashekaran, Lea W. Padgett, Anjali Ganjiwale, Jason P. Burgess
Publikováno v:
Pept Sci (Hoboken)
A peptide comprising the juxtamembrane C-terminal intracellular loop 4 (IL4) of the CB(1) cannabinoid receptor possesses three Serine residues (Ser402, Ser411 and Ser415). Here we report the effect of Ser phosphorylation on the CB(1) IL4 peptide conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fa599b6b6fc8b81134d3f7654d5b12d
https://europepmc.org/articles/PMC7224360/
https://europepmc.org/articles/PMC7224360/
Autor:
Martin J. Scanlon, Bankala Krishnarjuna, Christopher A. MacRaild, Indu R. Chandrashekaran, Hanudatta S. Atreya, Hiromasa Yagi, Shane M. Devine, San Sui Lim, Garima Jaipuria, Raymond S. Norton, Raymond W. Lam, Cael Debono, Peter J. Scammells
Publikováno v:
Journal of Molecular Recognition. 29:281-291
Plasmodium falciparum apical membrane antigen 1 (PfAMA1) plays an important role in the invasion by merozoites of human red blood cells during a malaria infection. A key region of PfAMA1 is a conserved hydrophobic cleft formed by 12 hydrophobic resid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f89a4b2b0db62b0e470a54512cac0bed
https://doi.org/10.1002/jmr.2529
https://doi.org/10.1002/jmr.2529