High quality gene annotation for deep phylogenetic analysis

Autor: Indrischek, Henrike

Gene prediction in newly sequenced genomes is a known challenging. Although sophisticated comparative pipelines are available, computationally derived gene models are often less than perfect. This is particularly true when multiple very similar paral

Externí odkaz: https://ul.qucosa.de/id/qucosa%3A31336
https://ul.qucosa.de/api/qucosa%3A31336/attachment/ATT-0/

Positive Selection in Gene Regulatory Factors Suggests Adaptive Pleiotropic Changes During Human Evolution

Autor: Jovanovic, Vladimir M., Sarfert, Melanie, Reyna-Blanco, Carlos S., Indrischek, Henrike, Valdivia, Dulce I., Shelest, Ekaterina, Nowick, Katja

Publikováno v: Frontiers in Genetics
Jovanovic, V M, Sarfert, M, Reyna-Blanco, C S, Indrischek, H, Valdivia, D I, Shelest, E & Nowick, K 2021, ' Positive selection in gene regulatory factors suggests adaptive pleiotropic changes during human evolution ', Frontiers in Genetics, vol. 12, 662239 . https://doi.org/10.3389/fgene.2021.662239

Gene regulatory factors (GRFs), such as transcription factors, co-factors and histone-modifying enzymes, play many important roles in modifying gene expression in biological processes. They have also been proposed to underlie speciation and adaptatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d593363e3a36d1849aa87a1d0e2032ee
http://europepmc.org/articles/PMC8166252

The paralog-to-contig assignment problem: high quality gene models from fragmented assemblies.

Autor: Indrischek, Henrike^1,2,3 henrike@bioinf.uni-leipzig.de, Wieseke, Nicolas⁴, Stadler, Peter F.^{2,3,5,6,7,8,9}, Prohaska, Sonja J.^1,3

Publikováno v: Algorithms for Molecular Biology. 2/24/2016, Vol. 10, p1-14. 14p.

The paralog-to-contig assignment problem

Autor: Indrischek, Henrike, Wieseke, Nicolas, Stadler, Peter F., Prohaska, Sonja J.

Background: The accurate annotation of genes in newly sequenced genomes remains a challenge. Although sophisticated comparative pipelines are available, computationally derived gene models are often less than perfect. This is particularly true when m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::ebe994f362315b8b4e6270cd4153ca46
https://publica.fraunhofer.de/handle/publica/243512

Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC

Autor: Höfling, Corinna, Indrischek, Henrike, Höpcke, Theodor, Waniek, Alexander, Cynis, Holger, Koch, Birgit, Schilling, Stephan, Morawski, Markus, Demuth, Hans-Ulrich, Roßner, Steffen, Hartlage-Rübsamen, Maike

Glutaminyl cyclases (QCs) catalyze the formation of pyroglutamate (pGlu) from glutamine precursors at the N-terminus of a number of peptide hormones, neuropeptides and chemokines. This post-translational modification stabilizes these peptides, protec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::5e542ebd4e5d437607c7a35c5f19bc45
https://publica.fraunhofer.de/handle/publica/236980