Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3 ⁺ RORγt ⁺ IL-17 ⁺ Tregs and improve metabolism.

Autor: Jensen BAH; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark. Benjamin.jensen@sund.ku.dk.; Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute, Laval University, Laval, QC, Canada. Benjamin.jensen@sund.ku.dk.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Benjamin.jensen@sund.ku.dk., Holm JB; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.; Clinical Microbiomics, Copenhagen, Denmark., Larsen IS; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.; Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute, Laval University, Laval, QC, Canada., von Burg N; Mucosal Immunology, Department of Health Technology, Technical University of Denmark, Copenhagen, Denmark., Derer S; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Sonne SB; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Pærregaard SI; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.; Mucosal Immunology, Department of Health Technology, Technical University of Denmark, Copenhagen, Denmark., Damgaard MV; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Integrative Metabolism and Environmental Influences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Indrelid SA; Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Oslo, Norway., Rivollier A; Mucosal Immunology, Department of Health Technology, Technical University of Denmark, Copenhagen, Denmark., Agrinier AL; Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute, Laval University, Laval, QC, Canada., Sulek K; Novo Nordisk Foundation Center for Basic Metabolic Research, Integrative Metabolism and Environmental Influences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Arnoldussen YJ; Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Oslo, Norway., Fjære E; Institute of Marine Research, Bergen, Norway., Marette A; Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute, Laval University, Laval, QC, Canada., Angell IL; Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Oslo, Norway., Rudi K; Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Oslo, Norway., Treebak JT; Novo Nordisk Foundation Center for Basic Metabolic Research, Integrative Metabolism and Environmental Influences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Madsen L; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.; Institute of Marine Research, Bergen, Norway., Åkesson CP; Department of Anatomy and Pathology, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway., Agace W; Mucosal Immunology, Department of Health Technology, Technical University of Denmark, Copenhagen, Denmark.; Immunology Section, Department of Experimental Medical Science, Lund University, Lund, Sweden., Sina C; Institute of Nutritional Medicine, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Kleiveland CR; Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Oslo, Norway., Kristiansen K; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark. kk@bio.ku.dk.; Institute of Metagenomics, BGI-Shenzhen, Shenzhen, P.R. China. kk@bio.ku.dk., Lea TE; Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Oslo, Norway. tor.lea@nmbu.no.

Publikováno v: Nature communications [Nat Commun] 2021 Feb 17; Vol. 12 (1), pp. 1093. Date of Electronic Publication: 2021 Feb 17.