Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder

Autor: Andrew W. Zimmerman, Kanwaljit Singh, Susan L. Connors, Hua Liu, Anita A. Panjwani, Li-Ching Lee, Eileen Diggins, Ann Foley, Stepan Melnyk, Indrapal N. Singh, S. Jill James, Richard E. Frye, Jed W. Fahey

Publikováno v: Molecular Autism, Vol 12, Iss 1, Pp 1-22 (2021)

Abstract Background Sulforaphane (SF), an isothiocyanate in broccoli, has potential benefits relevant to autism spectrum disorder (ASD) through its effects on several metabolic and immunologic pathways. Previous clinical trials of oral SF demonstrate

Externí odkaz: https://doaj.org/article/cfdd1aa8a2284064ac4e1899d7e775ee

Correction to: Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder

Autor: Andrew W. Zimmerman, Kanwaljit Singh, Susan L. Connors, Hua Liu, Anita A. Panjwani, Li‑Ching Lee, Eileen Diggins, Ann Foley, Stepan Melnyk, Indrapal N. Singh, S. Jill James, Richard E. Frye, Jed W. Fahey

Publikováno v: Molecular Autism, Vol 12, Iss 1, Pp 1-1 (2021)

Externí odkaz: https://doaj.org/article/4a6d45ef886a477085c6bce5bff063f9

Mitochondrial morphology is associated with respiratory chain uncoupling in autism spectrum disorder

Autor: Loïc Lionnard, Marie Tippett, Richard E. Frye, Abdel Aouacheria, Mathilde Fréchet, Karima Kissa, Leanna Delhey, Indrapal N. Singh, Amrit Ammanamanchi, Hanane Chajra, Patrick John McCarty, Shannon Rose, Mohammad A. Karim, Victor Racine

Publikováno v: Translational Psychiatry
Translational Psychiatry, Nature Pub. Group, 2021, 11 (1), pp.527. ⟨10.1038/s41398-021-01647-6⟩
Translational Psychiatry, 2021, 11 (1), pp.527. ⟨10.1038/s41398-021-01647-6⟩
Translational Psychiatry, Vol 11, Iss 1, Pp 1-17 (2021)

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is associated with unique changes in mitochondrial metabolism, including elevated respiration rates and morphological alterations. We examined electron transport chain (ETC) complex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a9c8c188b911fa330f9d2d8a0d52fd
https://hal.umontpellier.fr/hal-03388170

Correction to: Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder

Autor: Richard E. Frye, Eileen Diggins, S. Jill James, Li‑Ching ‑C Lee, Anita A. Panjwani, Ann Foley, Indrapal N. Singh, Jed W. Fahey, Stepan Melnyk, Andrew W. Zimmerman, Kanwaljit Singh, Susan L. Connors, Hua Liu

Publikováno v: Molecular Autism
Molecular Autism, Vol 12, Iss 1, Pp 1-1 (2021)

Sulforaphane (SF), an isothiocyanate in broccoli, has potential benefits relevant to autism spectrum disorder (ASD) through its effects on several metabolic and immunologic pathways. Previous clinical trials of oral SF demonstrated positive clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf473bde551906103ab227132db54363
https://doi.org/10.1186/s13229-021-00451-9

Additional file 1 of Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder

Autor: Zimmerman, Andrew W., Kanwaljit Singh, Connors, Susan L., Liu, Hua, Panjwani, Anita A., Li-Ching Lee, Diggins, Eileen, Foley, Ann, Melnyk, Stepan, Indrapal N. Singh, S. Jill James, Frye, Richard E., Fahey, Jed W.

Additional file 1. Additional Files: Table S1(A–D). Methods. Table S2. Characteristics of children who completed all visits vs children who dropped out of the study after 15 weeks. Table S3. OACIS-I scores not including severely affected subjects.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f8c10e58bb4513c0f2fb98362f32dc9