Výsledky vyhledávání - "Indranil Rao"

Role of hepatic blood flow and metabolism in the pharmacokinetics of ten drugs in lean, aged and obese rats

Autor: Ravikumar Nutakki, Prasanna Katnapally, Murali Subramanian, Chris Freeden, Sundeep Paruchury, Reeba K. Vikramadithyan, Indranil Rao, Priyadeep Bhutani, Vishwanath Kurawattimath, Punit Marathe, Chetan P Kulkarni, T. Thanga Mariappan, Pamela Abraham, Krishna Pocha, Sandhya Mandlekar

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 44(12)

1. The effect of age and obesity on the pharmacokinetics (PK), hepatic blood flow (HBF) and liver metabolism of 10 compounds was determined in rats. The animals fed a high-fat diet were defined as the diet-induced obese (DIO) group, while the animals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16b2c5da3efcba3c9d20ff9b59ec45e
https://pubmed.ncbi.nlm.nih.gov/24947446

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Pharmacodynamics

Autor: Indranil Rao, HK Vinay, Sandhya Mandlekar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c4f104a5fb52e559a2462f4cdb44cb7
https://doi.org/10.1002/9780470921920.edm037

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Down-regulation of heat shock protein 70 improves arsenic trioxide and 17-DMAG effects on constitutive signal transducer and activator of transcription 3 activity

Autor: Meir Wetzler, Sampa Ghoshal, William J. Jusko, Indranil Rao, Justin C. Earp

Publikováno v: Cancer chemotherapy and pharmacology. 66(4)

Signal transducer and activator of transcription 3 (STAT3) has been shown to be constitutively active in approximately 50% of patients with acute myeloid leukemia and is associated with worse outcome. Arsenic trioxide (ATO) synergizes with the heat s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9a93f899c8078f598b82b0fe1e3576
https://pubmed.ncbi.nlm.nih.gov/20035426

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Akademický článek

Role of hepatic blood flow and metabolism in the pharmacokinetics of ten drugs in lean, aged and obese rats.

Autor: Subramanian, Murali¹ (AUTHOR) murali.subramanian@syngeneintl.com, Kurawattimath, Vishwanath¹ (AUTHOR), Pocha, Krishna¹ (AUTHOR), Freeden, Chris² (AUTHOR), Rao, Indranil¹ (AUTHOR), Thanga Mariappan, T.¹ (AUTHOR), Marathe, Punit H.² (AUTHOR), Vikramadithyan, Reeba K.³ (AUTHOR), Abraham, Pamela² (AUTHOR), Kulkarni, Chetan P.¹ (AUTHOR), Katnapally, Prasanna¹ (AUTHOR), Nutakki, Ravikumar⁴ (AUTHOR), Paruchury, Sundeep¹ (AUTHOR), Bhutani, Priyadeep¹ (AUTHOR), Mandlekar, Sandhya⁵ (AUTHOR)

Publikováno v: Xenobiotica. Dec2014, Vol. 44 Issue 12, p1108-1116. 9p.

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Akademický článek

Computer-assembled cross-species/cross-modalities two-pore physiologically based pharmacokinetic model for biologics in mice and rats.

Autor: Sepp, Armin, Meno-Tetang, Guy, Weber, Andrew, Sanderson, Andrew, Schon, Oliver, Berges, Alienor

Publikováno v: Journal of Pharmacokinetics & Pharmacodynamics; Aug2019, Vol. 46 Issue 4, p339-359, 21p

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Akademický článek

Down-regulation of heat shock protein 70 improves arsenic trioxide and 17-DMAG effects on constitutive signal transducer and activator of transcription 3 activity.

Autor: Ghoshal, Sampa, Rao, Indranil, Earp, Justin C., Jusko, William J., Wetzler, Meir

Publikováno v: Cancer Chemotherapy & Pharmacology; Sep2010, Vol. 66 Issue 4, p681-689, 9p, 3 Charts, 4 Graphs

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