Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Indranil Malik"'
Autor:
Indranil Malik, Yi-Ju Tseng, Clare M. Wieland, Katelyn M. Green, Kristina Zheng, Katyanne Calleja, Peter K. Todd
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106212- (2023)
Neurodegeneration in Fragile X-associated tremor/ataxia syndrome (FXTAS) is caused by a CGG trinucleotide repeat expansion in the 5′ UTR of FMR1. Expanded CGG repeat RNAs form stable secondary structures, which in turn support repeat-associated non
Externí odkaz:
https://doaj.org/article/02931af5b6ea448b8b899a2cdab2453e
Autor:
Indranil Malik, Yi‐Ju Tseng, Shannon E Wright, Kristina Zheng, Prithika Ramaiyer, Katelyn M Green, Peter K Todd
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 11, Pp 1-21 (2021)
Abstract Transcribed CGG repeat expansions cause neurodegeneration in Fragile X‐associated tremor/ataxia syndrome (FXTAS). CGG repeat RNAs sequester RNA‐binding proteins (RBPs) into nuclear foci and undergo repeat‐associated non‐AUG (RAN) tra
Externí odkaz:
https://doaj.org/article/138cdabe97fa4b19802f057adaecf269
Autor:
Chenxi Qiu, Huiyan Jin, Irina Vvedenskaya, Jordi Abante Llenas, Tingting Zhao, Indranil Malik, Alex M. Visbisky, Scott L. Schwartz, Ping Cui, Pavel Čabart, Kang Hoo Han, William K. M. Lai, Richard P. Metz, Charles D. Johnson, Sing-Hoi Sze, B. Franklin Pugh, Bryce E. Nickels, Craig D. Kaplan
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-31 (2020)
Abstract Background The majority of eukaryotic promoters utilize multiple transcription start sites (TSSs). How multiple TSSs are specified at individual promoters across eukaryotes is not understood for most species. In Saccharomyces cerevisiae, a p
Externí odkaz:
https://doaj.org/article/46daed7ec1cd470898bd8a2909e78d14
Publikováno v:
Hum Mol Genet
Repeat-associated non-AUG (RAN) translation of expanded repeat-mutation mRNA produces toxic peptides in neurons of patients suffering from neurodegenerative diseases. Recent findings indicate that RAN translation in diverse model systems is not inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d0a9209a2a07a638f678fddae60f25
https://doi.org/10.1093/hmg/ddac021
https://doi.org/10.1093/hmg/ddac021
Autor:
Ha Eun, Kong, Junghwa, Lim, Alexander, Linsalata, Yunhee, Kang, Indranil, Malik, Emily G, Allen, Yiqu, Cao, Lisa, Shubeck, Rich, Johnston, Yanting, Huang, Yanghong, Gu, Xiangxue, Guo, Michael E, Zwick, Zhaohui, Qin, Thomas S, Wingo, Jorge, Juncos, David L, Nelson, Michael P, Epstein, David J, Cutler, Peter K, Todd, Stephanie L, Sherman, Stephen T, Warren, Peng, Jin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(22)
Fragile X–associated tremor/ataxia syndrome (FXTAS) is a debilitating late-onset neurodegenerative disease in premutation carriers of the expanded CGG repeat in FMR1 that presents with a spectrum of neurological manifestations, such as gait ataxia,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::41085d2235672607c137326ca7ff6f70
https://pubmed.ncbi.nlm.nih.gov/35617426
https://pubmed.ncbi.nlm.nih.gov/35617426
Autor:
Ha Eun Kong, Junghwa Lim, Alexander Linsalata, Yunhee Kang, Indranil Malik, Emily G. Allen, Yiqu Cao, Lisa Shubeck, Rich Johnston, Yanting Huang, Yanghong Gu, Xiangxue Guo, Michael E. Zwick, Zhaohui Qin, Thomas S. Wingo, Jorge Juncos, David L. Nelson, Michael P. Epstein, David J. Cutler, Peter K. Todd, Stephanie L. Sherman, Stephen T. Warren, Peng Jin
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance Expansion of 55-200 CGG repeats in the 5′ untranslated region of FMR1 predisposes carriers to fragile X–associated tremor/ataxia syndrome (FXTAS), a late-onset neurodegenerative disorder. FXTAS demonstrates incomplete penetrance, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1df20e3bb38f81d058ee328019f3f9f3
https://doi.org/10.1073/pnas.2118124119
https://doi.org/10.1073/pnas.2118124119
Autor:
Prithika Ramaiyer, Kristina Zheng, Peter K. Todd, Katelyn M. Green, Shannon E. Wright, Yi-Ju Tseng, Indranil Malik
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 11, Pp n/a-n/a (2021)
EMBO Molecular Medicine
EMBO Molecular Medicine
Transcribed CGG repeat expansions cause neurodegeneration in Fragile X‐associated tremor/ataxia syndrome (FXTAS). CGG repeat RNAs sequester RNA‐binding proteins (RBPs) into nuclear foci and undergo repeat‐associated non‐AUG (RAN) translation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408180c8affff8f76a184a211a670b18
https://doaj.org/article/138cdabe97fa4b19802f057adaecf269
https://doaj.org/article/138cdabe97fa4b19802f057adaecf269
Autor:
Pavlovic Em, Laperuta Aj, Indranil Malik, Mandar T. Naik, Craig D. Kaplan, Ugochuckwu S, Chenxi Qiu, Arora P
Thiolutin is a well-known and long-used natural product transcription inhibitor with an unresolved mode of action. Recent studies have identified Zn2+-chelation activity for both thiolutin and the related dithiolopyrrolone holomycin, with direct inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a3eba7047c2ce1d329ae34280b01eaa
https://doi.org/10.1101/2021.05.05.442806
https://doi.org/10.1101/2021.05.05.442806
Autor:
Prithika Ramaiyer, Peter K. Todd, Katelyn M. Green, Kristina Zheng, Yi-Ju Tseng, Indranil Malik, Shannon E. Wright
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by a transcribed CGG repeat expansion in the 5’ UTR ofFMR1. Expanded CGG repeat RNAs both sequester RNA-binding proteins (RBPs) into nuclear foci and undergo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c08bf868dc12cf09fe14c3bbc19bf39
https://doi.org/10.1101/2021.01.08.425998
https://doi.org/10.1101/2021.01.08.425998
Autor:
Jordi Abante Llenas, William K. M. Lai, Huiyan Jin, Richard P. Metz, Kang Hoo Han, Scott Schwartz, Tingting Zhao, B. Franklin Pugh, Charles D. Johnson, Ping Cui, Craig D. Kaplan, Irina O. Vvedenskaya, Indranil Malik, Sing-Hoi Sze, Bryce E. Nickels, Pavel Čabart, Alex M. Visbisky, Chenxi Qiu
Publikováno v:
Genome Biology
Genome Biology, Vol 21, Iss 1, Pp 1-31 (2020)
Genome Biology, Vol 21, Iss 1, Pp 1-31 (2020)
Background The majority of eukaryotic promoters utilize multiple transcription start sites (TSSs). How multiple TSSs are specified at individual promoters across eukaryotes is not understood for most species. In Saccharomyces cerevisiae, a pre-initia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5047049ff5ca8f0eae5f4db1590a816e
https://doi.org/10.1186/s13059-020-02040-0
https://doi.org/10.1186/s13059-020-02040-0