Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Indra Neil, Guha"'
Autor:
Christopher R. Bradley, Eleanor F. Cox, Naaventhan Palaniyappan, Guruprasad P. Aithal, Susan T. Francis, Indra Neil Guha
Publikováno v:
European Radiology Experimental, Vol 6, Iss 1, Pp 1-15 (2022)
Abstract Background We annually monitored stable compensated cirrhosis (CC) patients to evaluate serial variation in blood serum, liver stiffness, and multiparametric magnetic resonance imaging (mpMRI) measures to provide reference change values (RCV
Externí odkaz:
https://doaj.org/article/33131d69d77a41d29df7dbb15c6befaf
Autor:
Mette J. Nielsen, Grace E. Dolman, Rebecca Harris, Peder Frederiksen, Jane Chalmers, Jane I. Grove, William L. Irving, Morten A. Karsdal, Keyur Patel, Diana Julie Leeming, Indra Neil Guha
Publikováno v:
JHEP Reports, Vol 5, Iss 6, Pp 100743- (2023)
Background & Aims: Fibroblast activity is a key feature of fibrosis progression and organ function loss, leading to liver-related complications and mortality. The fibrogenesis marker, PRO-C3, has been shown to have prognostic significance in relation
Externí odkaz:
https://doaj.org/article/0e7fd31c9d4f4821b97670a60b11b3fe
Autor:
Isabel Graupera, Maja Thiele, Ann T. Ma, Miquel Serra-Burriel, Judit Pich, Núria Fabrellas, Llorenç Caballeria, Robert J. de Knegt, Ivica Grgurevic, Mathias Reichert, Dominique Roulot, Jörn M. Schattenberg, Juan M. Pericas, Paolo Angeli, Emmanuel A. Tsochatzis, Indra Neil Guha, Montserrat Garcia-Retortillo, Rosa M. Morillas, Rosario Hernández, Jordi Hoyo, Matilde Fuentes, Anita Madir, Adrià Juanola, Anna Soria, Marta Juan, Marta Carol, Alba Diaz, Sönke Detlefsen, Pere Toran, Guillem Pera, Céline Fournier, Anne Llorca, Phillip N. Newsome, Michael Manns, Harry J. de Koning, Feliu Serra-Burriel, Fernando Cucchietti, Anita Arslanow, Marko Korenjak, Laurens van Kleef, Josep Lluis Falcó, Patrick S. Kamath, Tom H. Karlsen, Laurent Castera, Frank Lammert, Aleksander Krag, Pere Ginès, for the LiverScreen Consortium investigators
Publikováno v:
BMC Public Health, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background The development of liver cirrhosis is usually an asymptomatic process until late stages when complications occur. The potential reversibility of the disease is dependent on early diagnosis of liver fibrosis and timely targeted tre
Externí odkaz:
https://doaj.org/article/190002eb7b394df3af13c8d603576ee0
Autor:
Hamish Innes, Hans Dieter Nischalke, Indra Neil Guha, Karl Heinz Weiss, Will Irving, Daniel Gotthardt, Eleanor Barnes, Janett Fischer, M. Azim Ansari, Jonas Rosendahl, Shang‐Kuan Lin, Astrid Marot, Vincent Pedergnana, Markus Casper, Jennifer Benselin, Frank Lammert, John McLauchlan, Philip L. Lutz, Victoria Hamill, Sebastian Mueller, Joanne R. Morling, Georg Semmler, Florian Eyer, Johann von Felden, Alexander Link, Arndt Vogel, Jens U. Marquardt, Stefan Sulk, Jonel Trebicka, Luca Valenti, Christian Datz, Thomas Reiberger, Clemens Schafmayer, Thomas Berg, Pierre Deltenre, Jochen Hampe, Felix Stickel, Stephan Buch
Publikováno v:
Hepatology Communications, Vol 6, Iss 5, Pp 1213-1226 (2022)
The host genetic background for hepatocellular carcinoma (HCC) is incompletely understood. We aimed to determine if four germline genetic polymorphisms, rs429358 in apolipoprotein E (APOE), rs2642438 in mitochondrial amidoxime reducing component 1 (M
Externí odkaz:
https://doaj.org/article/b9ad89289a29441c95f20c3bfffcbd53
Autor:
Isabel Graupera, Maja Thiele, Ann T. Ma, Miquel Serra-Burriel, Judit Pich, Núria Fabrellas, Llorenç Caballeria, Robert J. de Knegt, Ivica Grgurevic, Mathias Reichert, Dominique Roulot, Jörn M. Schattenberg, Juan M. Pericas, Paolo Angeli, Emmanuel A. Tsochatzis, Indra Neil Guha, Montserrat Garcia-Retortillo, Rosa M. Morillas, Rosario Hernández, Jordi Hoyo, Matilde Fuentes, Anita Madir, Adrià Juanola, Anna Soria, Marta Juan, Marta Carol, Alba Diaz, Sönke Detlefsen, Pere Toran, Guillem Pera, Céline Fournier, Anne Llorca, Phillip N. Newsome, Michael Manns, Harry J. de Koning, Feliu Serra-Burriel, Fernando Cucchietti, Anita Arslanow, Marko Korenjak, Laurens van Kleef, Josep Lluis Falcó, Patrick S. Kamath, Tom H. Karlsen, Laurent Castera, Frank Lammert, Aleksander Krag, Pere Ginès, for the LiverScreen Consortium investigators
Publikováno v:
BMC Public Health, Vol 23, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/760959d2296547bab818515c815e3993
Autor:
Sheila M. Grecian, Stela McLachlan, Jonathan A. Fallowfield, Peter C. Hayes, Indra Neil Guha, Joanne R. Morling, Stephen Glancy, Rachel M. Williamson, Rebecca M. Reynolds, Brian M. Frier, Nicola N. Zammitt, Jackie F. Price, Mark W. J. Strachan
Publikováno v:
Obesity Science & Practice, Vol 7, Iss 5, Pp 497-508 (2021)
Abstract Background Type 2 diabetes (T2D) is associated with increased risk of progression to cirrhosis and hepatocellular carcinoma (HCC) in people with chronic liver diseases, particularly non‐alcoholic fatty liver disease (NAFLD). However, the a
Externí odkaz:
https://doaj.org/article/1a7b4534a35442b38ce9ffd656a2d923
Autor:
Elliot Jokl, Jessica Llewellyn, Kara Simpson, Oluwatobi Adegboye, James Pritchett, Leo Zeef, Ian Donaldson, Varinder S. Athwal, Huw Purssell, Oliver Street, Lucy Bennett, Indra Neil Guha, Neil A. Hanley, Qing-Jun Meng, Karen Piper Hanley
Publikováno v:
Cells, Vol 12, Iss 12, p 1582 (2023)
Circadian rhythm governs many aspects of liver physiology and its disruption exacerbates chronic disease. CLOCKΔ19 mice disrupted circadian rhythm and spontaneously developed obesity and metabolic syndrome, a phenotype that parallels the progression
Externí odkaz:
https://doaj.org/article/7c82c154d4c7462eb47c9e7d418416e4
Autor:
Lucy Bennett, Huw Purssell, Oliver Street, Karen Piper Hanley, Joanne R. Morling, Neil A. Hanley, Varinder Athwal, Indra Neil Guha
Publikováno v:
Frontiers in Digital Health, Vol 4 (2022)
Chronic liver disease (CLD) is an ignored epidemic. Premature mortality is considerable and in the United Kingdom (UK) liver disease is in the top three for inequitable healthcare alongside heart and respiratory disease. Fifty percentage of patients
Externí odkaz:
https://doaj.org/article/24738c4bc34b4a0d83a2343127f12963
Autor:
Hamish Innes, Peter Jepsen, Scott McDonald, John Dillon, Victoria Hamill, Alan Yeung, Jennifer Benselin, April Went, Andrew Fraser, Andrew Bathgate, M. Azim Ansari, Stephen T. Barclay, David Goldberg, Peter C. Hayes, Philip Johnson, Eleanor Barnes, William Irving, Sharon Hutchinson, Indra Neil Guha
Publikováno v:
JHEP Reports, Vol 3, Iss 6, Pp 100384- (2021)
Background & Aims: Hepatocellular carcinoma (HCC) prediction models can inform clinical decisions about HCC screening provided their predictions are robust. We conducted an external validation of 6 HCC prediction models for UK patients with cirrhosis
Externí odkaz:
https://doaj.org/article/776f0b9432e44ddca1f7bb8a8c5de874
Autor:
Omar Elshaarawy, Johannes Mueller, Indra Neil Guha, Jane Chalmers, Rebecca Harris, Aleksander Krag, Bjørn Stæhr Madsen, Horia Stefanescu, Oana Farcau, Andreea Ardelean, Bogdan Procopet, Maja Thiele, Sebastian Mueller
Publikováno v:
JHEP Reports, Vol 1, Iss 2, Pp 99-106 (2019)
Background & Aims: Both liver stiffness (LS) and spleen stiffness (SS) are widely used to non-invasively assess liver fibrosis and portal hypertension, respectively. We aimed to identify the impact of disease etiology, namely the localization of infl
Externí odkaz:
https://doaj.org/article/93641426f6f64de5844796e74c1a25e1