Výsledky vyhledávání - "Indra Lübkemeier"

Akademický článek

Treatment with mononuclear cell populations improves post-infarction cardiac function but does not reduce arrhythmia susceptibility.

Autor: René P Andrié, Thomas Beiert, Vincent Knappe, Markus Linhart, Florian Stöckigt, Alexandra M Klein, Alexander Ghanem, Indra Lübkemeier, Wilhelm Röll, Georg Nickenig, Bernd K Fleischmann, Jan W Schrickel

Publikováno v: PLoS ONE, Vol 14, Iss 2, p e0208301 (2019)

BackgroundClinical and experimental data give evidence that transplantation of stem and progenitor cells in myocardial infarction could be beneficial, although the underlying mechanism has remained elusive. Ventricular tachyarrhythmia is the most fre

Externí odkaz: https://doaj.org/article/42a7fc93958043d48d793c61256ed9b6

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Treatment with mononuclear cell populations improves post-infarction cardiac function but does not reduce arrhythmia susceptibility

Autor: Wilhelm Röll, Alexandra M. Klein, Bernd K. Fleischmann, Georg Nickenig, Thomas Beiert, Jan W. Schrickel, René Andrié, Alexander Ghanem, Markus Linhart, Florian Stöckigt, Vincent Knappe, Indra Lübkemeier

Publikováno v: PLoS ONE, Vol 14, Iss 2, p e0208301 (2019)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463b72cf38192279a4d2c642709637b3
https://doaj.org/article/42a7fc93958043d48d793c61256ed9b6

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Human Connexin43E42K Mutation From a Sudden Infant Death Victim Leads to Impaired Ventricular Activation and Neonatal Death in Mice

Autor: Jung-Sun Kim, Daniela Malan, Bernd K. Fleischmann, Indra Lübkemeier, Felicitas Bosen, Klaus Willecke, Philipp Sasse

Publikováno v: Circulation: Cardiovascular Genetics. 8:21-29

Background— Sudden infant death syndrome (SIDS) describes the sudden, unexplained death of a baby during its first year of age and is the third leading cause of infant mortality. It is assumed that ≤20% of all SIDS cases are because of cardiac ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a1abba6747755a699e8e3de00482f4
https://doi.org/10.1161/circgenetics.114.000793

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Defective Cx40 Maintains Cx37 Expression but Intact Cx40 Is Crucial for Conducted Dilations Irrespective of Hypertension

Autor: Klaus Willecke, Indra Lübkemeier, Alexander Jobs, Armin Kurtz, Cor de Wit, Toon A.B. van Veen, Volker Schmidt, Kjestine Schmidt

Publikováno v: Hypertension. 60:1422-1429

The gap junction channel protein connexin40 (Cx40) is crucial in vascular and renal physiology, because Cx40-deficient mice exhibit impaired conduction of endothelium-dependent dilations and pronounced hypertension. The latter precludes mechanistic i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbee2cf51f8d3939c4b4d7e57e7381c
https://doi.org/10.1161/hypertensionaha.112.201194

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The Connexin40 A96S Mutation Causes Renin-Dependent Hypertension

Autor: Armin Kurtz, Björn Neubauer, Katharina Machura, Lisa Kurtz, Charlotte Wagner, Klaus Willecke, Indra Lübkemeier, Frank Schweda, Radoslaw Dobrowolski

Publikováno v: Journal of the American Society of Nephrology. 22:1031-1040

Deletion of the gap-junction-forming protein connexin40 leads to renin-dependent hypertension in mice, but whether observed human variants in connexin40, such as A96S, promote hypertension is unknown. Here, we generated mice with the A96S variant in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2348c9e5c6d28a795e203248e7583d
https://doi.org/10.1681/asn.2010101047

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The Connexin40A96S mutation from a patient with atrial fibrillation causes decreased atrial conduction velocities and sustained episodes of induced atrial fibrillation in mice

Autor: Klaus Willecke, Lars Lickfett, Jan W. Schrickel, Julien Fregeac, Astrid M. Draffehn, Feliksas F. Bukauskas, Indra Lübkemeier, Felicitas Bosen, René Andrié, Radoslaw Dobrowolski, Joachim L. Schultze, Florian Stöckigt

Publikováno v: Journal of molecular and cellular cardiology. 65

Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and a major cause of stroke. In the mammalian heart the gap junction proteins connexin40 (Cx40) and connexin43 (Cx43) are strongly expressed in the atrial myocardium mediating eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2315a2a0b41fb809625fe86276c2c0fa
https://pubmed.ncbi.nlm.nih.gov/24060583

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