Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Indra A Shaltiel"'
Autor:
Indra A. Shaltiel, Alba Llopis, Melinda Aprelia, Rob Klompmaker, Apostolos Menegakis, Lenno Krenning, René H. Medema
Publikováno v:
Cells, Vol 10, Iss 3, p 550 (2021)
Most Cyclin-dependent kinases (Cdks) are redundant for normal cell division. Here we tested whether these redundancies are maintained during cell cycle recovery after a DNA damage-induced arrest in G1. Using non-transformed RPE-1 cells, we find that
Externí odkaz:
https://doaj.org/article/6239935eb2eb4a59bf037fae1993f10b
Autor:
Indra A. Shaltiel, Sumanjit Datta, Léa Lecomte, Markus Hassler, Marc Kschonsak, Sol Bravo, Catherine Stober, Jenny Ormanns, Sebastian Eustermann, Christian H. Haering
Publikováno v:
Science (New York, N.Y.). 376(6597)
Structural maintenance of chromosomes (SMC) protein complexes structure genomes by extruding DNA loops, but the molecular mechanism that underlies their activity has remained unknown. We show that the active condensin complex entraps the bases of a D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31f6cb5b5964276abbe4a261b2ec381
https://pubmed.ncbi.nlm.nih.gov/35653469
https://pubmed.ncbi.nlm.nih.gov/35653469
Autor:
Gisela G Slaats, Amiya K Ghosh, Lucas L Falke, Stéphanie Le Corre, Indra A Shaltiel, Glenn van de Hoek, Timothy D Klasson, Marijn F Stokman, Ive Logister, Marianne C Verhaar, Roel Goldschmeding, Tri Q Nguyen, Iain A Drummond, Friedhelm Hildebrandt, Rachel H Giles
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004594 (2014)
We recently reported that centrosomal protein 164 (CEP164) regulates both cilia and the DNA damage response in the autosomal recessive polycystic kidney disease nephronophthisis. Here we examine the functional role of CEP164 in nephronophthisis-relat
Externí odkaz:
https://doaj.org/article/8629e9b555ce48b0b8ca20f4fda80cc6
Autor:
Rob Klompmaker, Alba Llopis, Lenno Krenning, Apostolos Menegakis, René H. Medema, Indra A. Shaltiel, Melinda Aprelia
Publikováno v:
Cells
Volume 10
Issue 3
Cells, Vol 10, Iss 550, p 550 (2021)
Volume 10
Issue 3
Cells, Vol 10, Iss 550, p 550 (2021)
Most Cyclin-dependent kinases (Cdks) are redundant for normal cell division. Here we tested whether these redundancies are maintained during cell cycle recovery after a DNA damage-induced arrest in G1. Using non-transformed RPE-1 cells, we find that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74aa21536457c88cbaee240277bc311
http://europepmc.org/articles/PMC7999910
http://europepmc.org/articles/PMC7999910
Autor:
Indra A. Shaltiel, Sebastian Eustermann, Sumanjit Datta, Christian H. Haering, Catherine Stober, Markus Hassler, Marc Kschonsak, Léa Lecomte, Sol Bravo
Publikováno v:
bioRxiv pre
bioRxiv
bioRxiv
SMC protein complexes structure genomes by extruding DNA loops, but the molecular mechanism that underlies their activity has remained unknown. We show that the active condensin complex entraps the bases of a DNA loop in two separate chambers. Single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb6854c4702979cf4d07eaace967608
Publikováno v:
Current Biology
Protein complexes built of Structural Maintenance of Chromosomes (SMC) and kleisin subunits, including cohesin, condensin and the Smc5/6 complex, are master organizers of genome architecture in all kingdoms of life. How these large ring-shaped molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b7c493bd2374630e01c4bdcfc0fcd2
https://doi.org/10.1016/j.cub.2018.08.034
https://doi.org/10.1016/j.cub.2018.08.034
Autor:
Eugene Kim, Christian H. Haering, Cees Dekker, Mahipal Ganji, Indra A. Shaltiel, Shveta Bisht, Ana Kalichava
Publikováno v:
Science, 360(6384)
Science
Science
Live imaging of DNA loop extrusion To spatially organize chromosomes, ring-shaped protein complexes including condensin and cohesin have been hypothesized to extrude DNA loops. Condensin has been shown to exhibit a DNA-translocating motor function, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4282f62666a168ff1206be8f681cb0a2
https://doi.org/10.1126/science.aar7831
https://doi.org/10.1126/science.aar7831
Publikováno v:
Nature
Nature: international weekly journal of science, 579(7799)
Nature: international weekly journal of science, 579(7799)
Condensin, a key member of the Structure Maintenance of Chromosome (SMC) protein complexes, has recently been shown to be a motor that extrudes loops of DNA1. It remains unclear, however, how condensin complexes work together to collectively package
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407943b6aff0b711b12f968a20bffdab
https://pubmed.ncbi.nlm.nih.gov/32132705
https://pubmed.ncbi.nlm.nih.gov/32132705
Publikováno v:
Molecular Cell. 55(1):59-72
Summary DNA damage can result in a transient cell-cycle arrest or lead to permanent cell-cycle withdrawal. Here we show that the decision to irreversibly withdraw from the cell cycle is made within a few hours following damage in G2 cells. This perma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66fa1eb09b41fb4843e5ce8178b8d9f
Autor:
René H. Medema, Indra A. Shaltiel, Dipanjan Chowdhury, Adrian T. Saurin, Emile E. Voest, Geert J. P. L. Kops, Melinda Aprelia
Publikováno v:
Proceedings of the National Academy of Sciences. 111:7313-7318
The basic machinery that detects DNA damage is the same throughout the cell cycle. Here, we show, in contrast, that reversal of DNA damage responses (DDRs) and recovery are fundamentally different in G1 and G2 phases of the cell cycle. We find that d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da972f146244507545c1742fb1bf928
https://doi.org/10.1073/pnas.1322021111
https://doi.org/10.1073/pnas.1322021111