Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Indole Compound"'
Autor:
Seira, Naofumi, Yanagisawa, Naoki, Suganami, Akiko, Honda, Takuya, Wasai, Makiko, Regan, John W, Fukushima, Keijo, Yamaguchi, Naoto, Tamura, Yutaka, Arai, Takayoshi, Murayama, Toshihiko, Fujino, Hiromichi
Increases in the expression of prostaglandin E2 (PGE2) are widely known to be involved in aberrant growth in the early stage of colon cancer development. We herein demonstrated that the novel indole compound MW-03 reduced PGE2-induced cAMP formation
Externí odkaz:
http://hdl.handle.net/10150/626040
http://arizona.openrepository.com/arizona/handle/10150/626040
http://arizona.openrepository.com/arizona/handle/10150/626040
Autor:
Perumal Gobinath, Ponnusamy Packialakshmi, Kaliappillai Vijayakumar, Magda H. Abdellattif, Mohd Shahbaaz, Akbar Idhayadhulla, Radhakrishnan Surendrakumar
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
This work investigated the interaction of indole with SARS-CoV-2. Indole is widely used as a medical material owing to its astounding biological activities. Indole and its derivatives belong to a significant category of heterocyclic compounds that ha
Publikováno v:
European Journal of Medicinal Chemistry. 138:1147-1157
Recently we described a novel class of imidazopyridine compounds that showed exceptional anti-RSV potency in cell culture. However, unfavorable pharmacokinetic (PK) properties and glutathione (GSH) adduct liabilities impeded their further development
Publikováno v:
Zoological Science. 34:173-178
Scyphozoa, Cubozoa and Hydrozoa are classes in the phylum Cnidaria that undergo metagenesis involving a dramatic morphological transition. In Scyphozoa and Cubozoa, when exposed to species- or strain-specific transition-inducing stimuli, asexually re
Autor:
Daniela Carbone, Godefridus J. Peters, Ugo Perricone, Elisa Giovannetti, Btissame El Hassouni, Girolamo Cirrincione, Giovanna Li Petri, Barbara Parrino, Stella Cascioferro, Vincenzo Arizza, Patrizia Diana, Niccola Funel, Alessandro Padova
Publikováno v:
Molecules, 25(2):329. Multidisciplinary Digital Publishing Institute
Molecules, Vol 25, Iss 2, p 329 (2020)
Molecules
Volume 25
Issue 2
Cascioferro, S, Li Petri, G, Parrino, B, el Hassouni, B, Carbone, D, Arizza, V, Perricone, U, Padova, A, Funel, N, Peters, G J, Cirrincione, G, Giovannetti, E & Diana, P 2020, ' 3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1H-Indole Derivatives as New Anticancer Agents in the Treatment of Pancreatic Ductal Adenocarcinoma ', Molecules, vol. 25, no. 2, 329 . https://doi.org/10.3390/molecules25020329
Molecules, Vol 25, Iss 2, p 329 (2020)
Molecules
Volume 25
Issue 2
Cascioferro, S, Li Petri, G, Parrino, B, el Hassouni, B, Carbone, D, Arizza, V, Perricone, U, Padova, A, Funel, N, Peters, G J, Cirrincione, G, Giovannetti, E & Diana, P 2020, ' 3-(6-Phenylimidazo [2,1-b][1,3,4]thiadiazol-2-yl)-1H-Indole Derivatives as New Anticancer Agents in the Treatment of Pancreatic Ductal Adenocarcinoma ', Molecules, vol. 25, no. 2, 329 . https://doi.org/10.3390/molecules25020329
A new series of imidazo[2,1-b][1,3,4]thiadiazole derivatives was efficiently synthesized and screened for their in vitro antiproliferative activity on a panel of pancreatic ductal adenocarcinoma (PDAC) cells, including SUIT-2, Capan-1 and Panc-1. Com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11826e84f8334a4af09a5097ea03b774
https://research.vumc.nl/en/publications/88636a25-c0fe-4d5a-8f45-5b79c613d01e
https://research.vumc.nl/en/publications/88636a25-c0fe-4d5a-8f45-5b79c613d01e
Autor:
Mathieu Marchivie, Anita Cohen, Jean Guillon, Catherine Mullié, Bertrand Courtioux, Clotilde Boudot, Vittoria Milano, Sandra Rubio, Pascal Sonnet, Solène Savrimoutou, Nadine Azas
Publikováno v:
Molbank, Vol 2019, Iss 2, p M1060 (2019)
Molbank
Molbank, 2019, 2019 (2), pp.M1060. ⟨10.3390/M1060⟩
Molbank, MDPI, 2019, 2019 (2), pp.M1060. ⟨10.3390/M1060⟩
Molbank
Molbank, 2019, 2019 (2), pp.M1060. ⟨10.3390/M1060⟩
Molbank, MDPI, 2019, 2019 (2), pp.M1060. ⟨10.3390/M1060⟩
1H-3-{4-[(3-Dimethylaminopropyl)aminomethyl]phenyl}-2-phenylindole was synthesized via a multi-step pathway starting from 2-iodoaniline. Structure characterization of this new indole compound was achieved by 1H-NMR, 13C-NMR and ESI-MS spectral analys
Autor:
Stoyan K. Karagiosov, Safwat M. Rabea, David S. Grierson, P. Richard Harrigan, Steven McArthur, Mitra Matloobi, Maryam Zamiri, Benoit Chabot, Laura E. Bandy, Peter K. Cheung, David Horhant
Publikováno v:
Journal of Medicinal Chemistry. 59:1869-1879
A 256-compound library was evaluated in an anti-HIV screen to identify structural "mimics" of the fused tetracyclic indole compound 1 (IDC16) that conserve its anti-HIV activity without associated cytotoxicity. Four diheteroarylamide-type compounds,
Publikováno v:
Molekul, Vol 15, Iss 1, Pp 9-17 (2020)
This study aimed to propose new indole derivatives as anticancer through Quantitative Structure-Activity Relationship (QSAR) and molecular docking method. The best predicted anticancer activity of indole derivatives was recommended based on the QSAR
Autor:
Włodzimierz Opoka, Katarzyna Kała, Klaudia Gaweł, Magdalena Zając, Katarzyna Sułkowska-Ziaja, Bożena Muszyńska
Publikováno v:
LWT - Food Science and Technology. 62:27-31
The study consisted of experiments using edible mushroom species: Agaricus bisporus, Boletus badius and Cantharellus cibarius. As far as we know, there is no information about the release of indole compounds from mushrooms in the human body. The rate
Autor:
Makiko Wasai, John W. Regan, Yutaka Tamura, Naofumi Seira, Akiko Suganami, Takayoshi Arai, Hiromichi Fujino, Naoki Yanagisawa, Keijo Fukushima, Takuya Honda, Toshihiko Murayama, Naoto Yamaguchi
Publikováno v:
Biologicalpharmaceutical bulletin. 40(10)
Ministry of Education, Culture, Sports, Science and Technology of Japan [JP17K08308]; Center of Excellence (COE) program from Chiba University of Japan