Výsledky vyhledávání - "Inder M Verma"

Akademický článek

Antiapoptotic Role for Lifeguard in T Cell Mediated Immune Response.

Autor: Tatiana Hurtado de Mendoza, Fei Liu, Inder M Verma

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0142161 (2015)

Anti-apoptotic protein Lifeguard (LFG) is upregulated on T cells upon in vitro activation. To investigate its role in T cell immunity we infected wild type and LFG knockout bone marrow chimaeras mice with LCMV. We observed a decreased number of LFG K

Externí odkaz: https://doaj.org/article/b2536f260fb04f149df431fce7ebdd99

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Akademický článek

A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation.

Autor: Smarajit Polley, De-Bin Huang, Arthur V Hauenstein, Amanda J Fusco, Xiangyang Zhong, Don Vu, Bärbel Schröfelbauer, Youngchang Kim, Alexander Hoffmann, Inder M Verma, Gourisankar Ghosh, Tom Huxford

Publikováno v: PLoS Biology, Vol 11, Iss 6, p e1001581 (2013)

Activation of the IκB kinase (IKK) is central to NF-κB signaling. However, the precise activation mechanism by which catalytic IKK subunits gain the ability to induce NF-κB transcriptional activity is not well understood. Here we report a 4 Å x-r

Externí odkaz: https://doaj.org/article/43e7e959d3ba4586a7f0c6da67fd6cc8

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Akademický článek

Tumor suppressor p53 functions as a negative regulator in IgE-mediated mast cell activation.

Autor: Kotaro Suzuki, Samantha H Murphy, Yifeng Xia, Masaya Yokota, Daiki Nakagomi, Fei Liu, Inder M Verma, Hiroshi Nakajima

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e25412 (2011)

Mast cells are known to play a pivotal role in allergic diseases such as allergic rhinitis, asthma, and atopic dermatitis by releasing granules containing histamine, LTC4, and other preformed chemical mediators. Previous reports have demonstrated tha

Externí odkaz: https://doaj.org/article/b18c6319f2204515b8636cd3c70d47fe

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Akademický článek

Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease.

Autor: Brian Spencer, Robert A Marr, Ryan Gindi, Rewati Potkar, Sarah Michael, Anthony Adame, Edward Rockenstein, Inder M Verma, Eliezer Masliah

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e16575 (2011)

Alzheimer's disease (AD), an incurable, progressive neurodegenerative disorder, is the most common form of dementia. Therapeutic options have been elusive due to the inability to deliver proteins across the blood-brain barrier (BBB). In order to impr

Externí odkaz: https://doaj.org/article/f14e2b21522a4a819eefd31029fe5038

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Data from Targeting CREB Pathway Suppresses Small Cell Lung Cancer

Autor: Inder M. Verma, Narayana Yeddula, Eugene Ke, Mathias Leblanc, Mingxiang Feng, Cheng Zhan, Yifeng Xia

Small cell lung cancer (SCLC) is the most deadly subtype of lung cancer due to its dismal prognosis. We have developed a lentiviral vector-mediated SCLC mouse model and have explored the role of both the NF-κB and CREB families of transcription fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67d1721f6af24c53cf181f1fb6e13e04
https://doi.org/10.1158/1541-7786.c.6541270

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OTME-7. Cancer - immune cell interactions drive transitions to mesenchymal-like state in glioblastoma

Publikováno v: Neuro-Oncology Advances. 3:ii14-ii15

Communication between cancer cells and immune cells is a key determinant of the glioblastoma ecosystem and its response to therapies, but remains poorly understood. Here we leveraged single-cell RNA-sequencing (scRNA-seq) of human samples and mouse m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41bb58951ba6d02742d18d4999e5fc20
https://doi.org/10.1093/noajnl/vdab070.058

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