Integrating microRNA expression, miRNA-mRNA regulation network and signal pathway: a novel strategy for lung cancer biomarker discovery

Autor: Renqing Nie, Wenling Niu, Tang Tang, Jin Zhang, Xiaoyi Zhang

Publikováno v: PeerJ, Vol 9, p e12369 (2021)

Background Since there are inextricably connections among molecules in the biological networks, it would be a more efficient and accurate research strategy to screen microRNA (miRNA) markers combining with miRNA-mRNA regulatory networks. The independ

Externí odkaz: https://doaj.org/article/3761eb13f33a4b028cefc997c93eb26e

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Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea

Autor: Hang Wu, Yansheng Wang, Li Yuan, Yongrong Mao, Weiwei Wang, Lin Zhu, Panpan Wu, Chengzhang Fu, Rolf Müller, David T. Weaver, Lixin Zhang, Buchang Zhang

Publikováno v: Synthetic and Systems Biotechnology, Vol 1, Iss 1, Pp 39-46 (2016)

Erythromycin A is a widely used antibiotic produced by Saccharopolyspora erythraea; however, its biosynthetic cluster lacks a regulatory gene, limiting the yield enhancement via regulation engineering of S. erythraea. Herein, six TetR family transcri

Externí odkaz: https://doaj.org/article/e47d1d79d04c4605adcfdc4a2ca15204

Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea

Autor: David T. Weaver, Weiwei Wang, Chengzhang Fu, Yongrong Mao, Lixin Zhang, Panpan Wu, Hang Wu, Lin Zhu, Li Yuan, Yansheng Wang, Rolf Müller, Buchang Zhang

Publikováno v: Synthetic and Systems Biotechnology
Synthetic and Systems Biotechnology, Vol 1, Iss 1, Pp 39-46 (2016)

Erythromycin A is a widely used antibiotic produced by Saccharopolyspora erythraea; however, its biosynthetic cluster lacks a regulatory gene, limiting the yield enhancement via regulation engineering of S. erythraea. Herein, six TetR family transcri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42d3b525a2f63f92184734efe3cc261
http://europepmc.org/articles/PMC5640589

Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea .

Autor: Wu H; Institute of Health Sciences, School of Life Sciences, Anhui University, Hefei 230601, China., Wang Y; Institute of Health Sciences, School of Life Sciences, Anhui University, Hefei 230601, China., Yuan L; Institute of Health Sciences, School of Life Sciences, Anhui University, Hefei 230601, China., Mao Y; Institute of Health Sciences, School of Life Sciences, Anhui University, Hefei 230601, China., Wang W; Institute of Health Sciences, School of Life Sciences, Anhui University, Hefei 230601, China., Zhu L; Institute of Health Sciences, School of Life Sciences, Anhui University, Hefei 230601, China., Wu P; Institute of Health Sciences, School of Life Sciences, Anhui University, Hefei 230601, China., Fu C; CAS Key Laboratory of Pathogenic Microbiology & Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.; Helmholtz Institute for Pharmaceutical Research, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland University, P.O. Box 15115, 66041 Saarbrücken, Germany., Müller R; Helmholtz Institute for Pharmaceutical Research, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland University, P.O. Box 15115, 66041 Saarbrücken, Germany., Weaver DT; Institute of Health Sciences, School of Life Sciences, Anhui University, Hefei 230601, China., Zhang L; Institute of Health Sciences, School of Life Sciences, Anhui University, Hefei 230601, China.; CAS Key Laboratory of Pathogenic Microbiology & Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China., Zhang B; Institute of Health Sciences, School of Life Sciences, Anhui University, Hefei 230601, China.

Publikováno v: Synthetic and systems biotechnology [Synth Syst Biotechnol] 2016 Feb 16; Vol. 1 (1), pp. 39-46. Date of Electronic Publication: 2016 Feb 16 (Print Publication: 2016).