Výsledky vyhledávání - "Inci KAZKAYASI"

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Intranasal metformin treatment ameliorates cognitive functions via insulin signaling pathway in ICV-STZ-induced mice model of Alzheimer's disease

Autor: Inci, Kazkayasi, Gokcen, Telli, Emirhan, Nemutlu, Serdar, Uma

Publikováno v: Life Sciences. 299:120538

The relationship between type 2 diabetes and Alzheimer's disease (AD) provides evidence that insulin and insulin sensitizers may be beneficial for the treatment of AD. The present study investigated the effect and mechanism of action of intranasal me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca5fc4e473c0e046a901386a18ae42e
https://doi.org/10.1016/j.lfs.2022.120538

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Efeito de 5-hidroxitriptofano no edema de pata de camundongo induzido por carragenina

Autor: Gokçen TELLI, Inci KAZKAYASI, Serdar UMA

Publikováno v: Revista de Nutrição v.34 2021
Revista de Nutrição
Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
Revista de Nutrição, Volume: 34, Article number: e200119, Published: 02 JUN 2021
Revista de Nutrição, Vol 34 (2021)

Objective 5-Hydroxytryptophan is the precursor compound of serotonin biosynthesis. The oral absorption of 5-Hydroxytryptophan is close to 100% and, unlike serotonin, it crosses the blood-brain barrier freely. 5-Hydroxytryptophan has been used as a fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f71da31226abe57c1d19bbdaab3a19
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52732021000100315

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Insulin deprivation decreases insulin degrading enzyme levels in primary cultured cortical neurons and in the cerebral cortex of rats with streptozotocin-induced diabetes

Autor: Nihan Burul-Bozkurt, Inci Kazkayasi, Angel Cedazo-Minguez, Can Pekiner, Muhammad-Al-Mustafa Ismail, Serdar Uma, Paula Merino-Serrais

Publikováno v: Pharmacological Reports. 70:677-683

Background Many studies have indicated a relationship between diabetes and Alzheimer’s disease (AD). However, the molecular mechanism underlying this association has not been clarified. Among several factors, insulin degrading enzyme (IDE), which p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aea305d255ecb88b6f65bcc5e22f9fd
https://doi.org/10.1016/j.pharep.2018.01.008

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Lack of insulin results in reduced seladin-1 expression in primary cultured neurons and in cerebral cortex of STZ-induced diabetic rats

Autor: Ingemar Björkhem, Angel Cedazo-Minguez, Can Pekiner, Nihan Burul-Bozkurt, Muhammad-Al-Mustafa Ismail, Inci Kazkayasi, Cristina Parrado-Fernandez, Serdar Uma

Publikováno v: Neuroscience Letters. 633:174-181

Several studies demonstrated that Diabetes mellitus (DM) enhances the risk for Alzheimer's disease (AD). Although hyperglycemia and perturbed function of insulin signaling have been proposed to contribute to AD pathogenesis, the molecular mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83836aa8eece009bc196e3447d2b9ac8
https://doi.org/10.1016/j.neulet.2016.09.018

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Design and Synthesis of 1,2,4-Triazolo[3,2-b]-1,3,5-thiadiazine Derivatives as a Novel Template for Analgesic/Anti-Inflammatory Activity

Autor: Seyma, Sert-Ozgur, Banu C, Tel, Elif I, Somuncuoglu, Inci, Kazkayasi, Mevlut, Ertan, Birsen, Tozkoparan

Publikováno v: Archiv der Pharmazie. 350(7)

Previously, we demonstrated that certain heterocyclic compounds derived from 3-substituted-1,2,4-triazole-5-thiones had promising analgesic/anti-inflammatory activities together with low ulcerogenic properties. Therefore, we sought to design and synt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d5607475d2d8c7a7be7f81ab8829ea0c
https://pubmed.ncbi.nlm.nih.gov/28594090

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Effects of Experimental Diabetes on C/EBP Proteins in Rat Hippocampus, Sciatic Nerve and Ganglia

Autor: Nihan Burul-Bozkurt, Inci Kazkayasi, Pelin Kelicen-Ugur, Can Pekiner, Sevgen Onder

Publikováno v: Cellular and Molecular Neurobiology. 33:559-567

Neurodegeneration is one of the most important complications of diabetes mellitus (DM). The exact mechanisms underlying neurodegeneration related to diabetic complications such as cognitive deficits and peripheral neuropathy are not clarified yet. Du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbc126ff239b7fff87d22cbe377bd6d
https://doi.org/10.1007/s10571-013-9924-9

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Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies

Autor: Birsen Tozkoparan, Ayse Uzgoren-Baran, Banu Cahide Tel, Mevlüt Ertan, Deniz Sarıgöl, Gürol Okay, Oya Unsal-Tan, Keriman Ozadali-Sari, Inci Kazkayasi, Elif Inci Somuncuoglu

3-Substituted-1,2,4-triazole-5-thiones are versatile synthetic intermediates for the preparation of several biologically active N-bridged heterocyclic compounds, given that they have two reactive sites, thiocarbonyl and an amine nitrogen (N-1/N-4). F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba9f94d8ddbbc3a72d29b20d87da1f8
https://hdl.handle.net/11503/1403

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