Enabling Allogeneic T Cell-Based Therapies: Scalable Stirred-Tank Bioreactor Mediated Manufacturing

Autor: Himavanth Gatla, Nicholas Uth, Yonatan Levinson, Ali Navaei, Alex Sargent, Senthil Ramaswamy, Inbar Friedrich Ben-Nun

Publikováno v: Frontiers in Medical Technology, Vol 4 (2022)

Allogeneic T cells are key immune therapeutic cells to fight cancer and other clinical indications. High T cell dose per patient and increasing patient numbers result in clinical demand for a large number of allogeneic T cells. This necessitates a ma

Externí odkaz: https://doaj.org/article/5eff959ed6b74b978920b0c846a13e67

Expansion of Human Pluripotent Stem Cells in Stirred Tank Bioreactors

Autor: Marites T, Woon, Puspa R, Pandey, Inbar, Friedrich Ben-Nun

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2436

Bioreactor technolology enables the expansion of mammalian cells, which can be translated to processes compatible with Current Good Manufacturing Practice (cGMP) regulations. Cells are introduced to the bioreactor vessel, wherein key parameters such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5dc108ba294d54cbe557f71bdd988351
https://pubmed.ncbi.nlm.nih.gov/33959915

Bespoke cell therapy manufacturing platforms

Autor: Yonatan Levinson, Rajesh G. Beri, Inbar Friedrich Ben-Nun, Kathryn Holderness, Shi Yaling, Eytan Abraham

Publikováno v: Biochemical Engineering Journal. 132:262-269

There is an emerging need for flexible platforms capable of manufacturing cell products at large scale for both allogeneic and autologous therapeutics. These platforms must be capable of both scaling up and scaling out, while maintaining control over

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdeef84286f9833c2469e642de43a73a
https://doi.org/10.1016/j.bej.2018.01.023

Rewinding the process of mammalian extinction

Autor: Frank Göritz, Steven Seet, Jan Stejskal, Joseph Saragusty, Jeanne F. Loring, Stacey Johnson, Thomas B. Hildebrandt, Cesare Galli, Thomas Voracek, Oliver A. Ryder, Marilyn B. Renfree, Pasqualino Loi, Keisuke Okita, Inbar Friedrich Ben-Nun, Robert Hermes, Barbara S. Durrant, Katsuhiko Hayashi, Micha Drukker, Giovanna Lazzari, Sebastian Diecke, Susanne Holtze

Publikováno v: Zoo Biol. 35, 280-292 (2016)
Zoo biology, 35(4): 280-292
ZOO Biology, 35(4), 280-292. WILEY
ZOO Biology

With only three living individuals left on this planet, the northern white rhinoceros (Ceratotherium simum cottoni) could be considered doomed for extinction. It might still be possible, however, to rescue the (sub)species by combining novel stem cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47076364db03d4ee4c361cb8f5d548ae
https://pubmed.ncbi.nlm.nih.gov/27142508

A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics

Autor: Louise C. Laurent, Karen Sabatini, Amy Mitrano, Claudia Chavarria, Tomas Marques-Bonet, Irene Gallego Romero, Irene Hernando-Herraez, Xiang Zhou, Yingchun Li, Constance H. Huang, Bryan J Pavlovic, Yoav Gilad, Courtney L. Kagan, Mana M. Parast, Trevor R. Leonardo, Michelle C Ward, Jeanne F. Loring, Jonathan E. Burnett, Inbar Friedrich Ben-Nun, Nicholas E. Banovich

Publikováno v: eLife, Vol 4 (2015)
eLife, vol 4, iss JUNE 2015
Recercat. Dipósit de la Recerca de Catalunya
instname
eLife
Gallego Romero, Irene; Pavlovic, Bryan J; Hernando-Herraez, Irene; Zhou, Xiang; Ward, Michelle C; Banovich, Nicholas E; et al.(2015). A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics.. eLife, 4, e07103. doi: 10.7554/eLife.07103. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/5zd3k6g8

Comparative genomics studies in primates are restricted due to our limited access to samples. In order to gain better insight into the genetic processes that underlie variation in complex phenotypes in primates, we must have access to faithful model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74df14a3240538a2ead44a488e20b0a
https://elifesciences.org/articles/07103