Ferulic acid interventions ameliorate NDEA-CCl 4 -induced hepatocellular carcinoma via Nrf2 and p53 upregulation and Akt/PKB-NF-κB-TNF-α pathway downregulation in male Wistar rats.

Autor: Somade OT; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., Ajayi BO; Department of Chemical Sciences, Faculty of Natural Sciences, Ajayi Crowther University, Oyo, Nigeria., Adeyi OE; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., Dada TA; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., Ayofe MA; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., Inalu DC; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., Ajiboye OI; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., Shonoiki OM; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., Adelabu AO; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., Onikola RT; Key Laboratory of Green Process and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China., Isiaka ID; Center for Bacteria and Viruses Resources and Bioinformation, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China., Omotoso O; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., James AS; School of Biomedical Sciences, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA., Olaniyan TO; Instituto Politécnico Nacional, Centro de Biotecnologĭa Genómica, Reynosa 88710, Mexico., Adegoke AM; Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan 200005, Nigeria., Akamo AJ; Department of Biochemistry, College of Biosciences, Federal University of Agriculture, Abeokuta, Nigeria., Oyinloye BE; Phytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, College of Sciences, Afe Babalola University, PMB, 5454, Ado-Ekiti 360001, Nigeria., Adewole E; Industrial Chemistry Unit, Department of Chemical Sciences, College of Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.

Publikováno v: Toxicology reports [Toxicol Rep] 2024 Jan 14; Vol. 12, pp. 119-127. Date of Electronic Publication: 2024 Jan 14 (Print Publication: 2024).