TLR-9 agonist and CD40-targeting vaccination induces HIV-1 envelope-specific B cells with a diversified immunoglobulin repertoire in humanized mice

Autor: Sandra Zurawski, Hugo Mouquet, Craig Fenwick, Lishan Su, Laurine Gil, Giuseppe Pantaleo, Gerard Zurawski, Jean-Daniel Lelièvre, Mireille Centlivre, Pierre Milpied, Véronique Godot, Liang Cheng, Inaki Cervera-Marzal, Yves Levy, Colas Tcherakian, Guangming Li, Sylvain Cardinaud, Nicolas Ortonne

Publikováno v: PLoS Pathogens, Vol 16, Iss 11, p e1009025 (2020)
PLoS Pathogens

The development of HIV-1 vaccines is challenged by the lack of relevant models to accurately induce human B- and T-cell responses in lymphoid organs. In humanized mice reconstituted with human hematopoietic stem cells (hu-mice), human B cell-developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd566aed39b9bc4e6a93c43c834bda17
https://doaj.org/article/f6bce71944994a6da24af9bb42fbab3b

Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis

Autor: Sophie Conchon, Alexandra Garcia, Béatrice Clémenceau, Fabienne Vavasseur, Sarah Habes, Hélène Aublé, Sophie Brouard, Laurine Gil, Florence Tanné, Anaïs Cardon, David-Axel Laplaud, Caroline Chevalier, Jean-Paul Judor, Jean-François Mosnier, Pierre Milpied, Chuang Dong, Jérôme Gournay, Inaki Cervera-Marzal, Erwan Kervagoret, Amédée Renand

Publikováno v: Journal of Hepatology
Journal of Hepatology, Elsevier, 2020, ⟨10.1016/j.jhep.2020.05.053⟩
Journal of Hepatology, 2020, ⟨10.1016/j.jhep.2020.05.053⟩

International audience; Background & aims: In most autoimmune disorders, crosstalk of B cells and CD4 T cells results in the accumulation of autoantibodies. In autoimmune hepatitis (AIH), the presence of anti-soluble liver antigen (SLA) autoantibodie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b342f7438e6a10f6a78d17c13e796e89
https://hal.archives-ouvertes.fr/hal-02982210

FB5P-seq: FACS-Based 5-Prime End Single-Cell RNA-seq for Integrative Analysis of Transcriptome and Antigen Receptor Repertoire in B and T Cells

Autor: Pierre Milpied, Chuang Dong, Lionel Spinelli, Inaki Cervera-Marzal, Noudjoud Attaf, Laurine Gil, Amédée Renand

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, 2020, 11, pp.216. ⟨10.3389/fimmu.2020.00216⟩
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Frontiers, 2020, 11, pp.216. ⟨10.3389/fimmu.2020.00216⟩

Single-cell RNA sequencing (scRNA-seq) allows the identification, characterization, and quantification of cell types in a tissue. When focused on B and T cells of the adaptive immune system, scRNA-seq carries the potential to track the clonal lineage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad3a06e54016498518fbcd985b09d72
https://doi.org/10.3389/fimmu.2020.00216

Single-Cell RNA Sequencing Identifies a Pseudo-Immune Differentiation Axis As the Main Source of Functional Heterogeneity in Follicular Lymphoma B-Cells

Autor: Bertrand Nadel, Laurine Gil, Chuang Dong, Noudjoud Attaf, Jean-Marc Navarro, Lionel Spinelli, Pierre Milpied, Inaki Cervera-Marzal

Publikováno v: Blood. 134:548-548

Introduction Follicular Lymphoma (FL), the second most frequent lymphoma in adults, often presents as a disseminated disease at diagnosis. Despite a generally slow progression and a median overall survival of more than 15 years with current chemo-imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c55b7a6e090fc25cc66fb23f5107cd8c
https://doi.org/10.1182/blood-2019-125718

TLR-9 agonist and CD40-targeting vaccination induces HIV-1 envelope-specific B cells with a diversified immunoglobulin repertoire in humanized mice.

Autor: Véronique Godot, Colas Tcherakian, Laurine Gil, Iñaki Cervera-Marzal, Guangming Li, Liang Cheng, Nicolas Ortonne, Jean-Daniel Lelièvre, Giuseppe Pantaleo, Craig Fenwick, Mireille Centlivre, Hugo Mouquet, Sylvain Cardinaud, Sandra M Zurawski, Gerard Zurawski, Pierre Milpied, Lishan Su, Yves Lévy

Publikováno v: PLoS Pathogens, Vol 16, Iss 11, p e1009025 (2020)

The development of HIV-1 vaccines is challenged by the lack of relevant models to accurately induce human B- and T-cell responses in lymphoid organs. In humanized mice reconstituted with human hematopoietic stem cells (hu-mice), human B cell-developm

Externí odkaz: https://doaj.org/article/f6bce71944994a6da24af9bb42fbab3b