Výsledky vyhledávání - "Inaki Cervera-Marzal"

TLR-9 agonist and CD40-targeting vaccination induces HIV-1 envelope-specific B cells with a diversified immunoglobulin repertoire in humanized mice

Autor: Sandra Zurawski, Hugo Mouquet, Craig Fenwick, Lishan Su, Laurine Gil, Giuseppe Pantaleo, Gerard Zurawski, Jean-Daniel Lelièvre, Mireille Centlivre, Pierre Milpied, Véronique Godot, Liang Cheng, Inaki Cervera-Marzal, Yves Levy, Colas Tcherakian, Guangming Li, Sylvain Cardinaud, Nicolas Ortonne

Publikováno v: PLoS Pathogens, Vol 16, Iss 11, p e1009025 (2020)
PLoS Pathogens

The development of HIV-1 vaccines is challenged by the lack of relevant models to accurately induce human B- and T-cell responses in lymphoid organs. In humanized mice reconstituted with human hematopoietic stem cells (hu-mice), human B cell-developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd566aed39b9bc4e6a93c43c834bda17
https://doaj.org/article/f6bce71944994a6da24af9bb42fbab3b

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The activation trajectory of plasmacytoid dendritic cells in vivo during a viral infection

Autor: Jean-Luc Davignon, Karima Naciri, Rabie Chelbi, Gilles Bessou, Chuang Dong, Nils Collinet, Michael Valente, Geoffray Brelurut, Pierre Milpied, Abdenour Abbas, Morgane Thomas-Chollier, Noudjoud Attaf, Thien-Phong Vu Manh, Inaki Cervera-Marzal, Alexandra-Chloé Villani, Benjamin Rauwel, Denis Thieffry, Marc Dalod, Elena Tomasello

Publikováno v: Nature Immunology
Nature Immunology, Nature Publishing Group, 2020, 21 (9), pp.983-997. ⟨10.1038/s41590-020-0731-4⟩
Nature Immunology, 2020, 21 (9), pp.983-997. ⟨10.1038/s41590-020-0731-4⟩
Nature immunology

International audience; Plasmacytoid dendritic cells (pDCs) are a major source of type I interferon (IFN-I). What other functions pDCs exert in vivo during viral infections is controversial, and more studies are needed to understand their orchestrati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd76519d3ec2c2f1de126656bc2665f9
https://hal.archives-ouvertes.fr/hal-02980944/file/2020_11_30_Abbas_et_al_2020_accepted_manuscript_for_HAL_small_size.pdf

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Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis

Publikováno v: Journal of Hepatology
Journal of Hepatology, Elsevier, 2020, ⟨10.1016/j.jhep.2020.05.053⟩
Journal of Hepatology, 2020, ⟨10.1016/j.jhep.2020.05.053⟩

International audience; Background & aims: In most autoimmune disorders, crosstalk of B cells and CD4 T cells results in the accumulation of autoantibodies. In autoimmune hepatitis (AIH), the presence of anti-soluble liver antigen (SLA) autoantibodie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b342f7438e6a10f6a78d17c13e796e89
https://hal.archives-ouvertes.fr/hal-02982210

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Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis

Autor: Sarah Habes, Jérôme Gournay, Anaïs Cardon, Amédée Renand, Erwan Kervagoret, Pierre Milpied, Inaki Cervera-Marzal, Chuang Dong, Hélène Aublé, Sophie Brouard, Sophie Conchon, Jean-Paul Judor, Laurine Gil, Jean-François Mosnier

Background & AimsIn most autoimmune disorders, crosstalk of B cells and CD4 T cells results in the accumulation of autoantibodies. In autoimmune hepatitis (AIH), the presence of anti-Soluble Liver Antigen (SLA or SepSecs) autoantibodies is associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a5ded3dd96e90a3b9c96ce254279b18
https://doi.org/10.1101/2020.01.06.895938

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Human germinal center transcriptional programs are de-synchronized in B cell lymphoma

Autor: Gabriel Brisou, Alexandra Traverse-Glehen, Bertrand Nadel, Bruno Tesson, Gilles Salles, Pierre Milpied, Marie-Laure Mollichella, Inaki Cervera-Marzal, Lionel Spinelli

Publikováno v: Nature Immunology
Nature Immunology, Nature Publishing Group, 2018, 19 (9), pp.1013-1024. ⟨10.1038/s41590-018-0181-4⟩
Nature Immunology, 2018, 19 (9), pp.1013-1024. ⟨10.1038/s41590-018-0181-4⟩

International audience; Most adult B cell lymphomas originate from germinal center (GC) B cells, but it is unclear to what extent B cells in overt lymphoma retain the functional dynamics of GC B cells or are blocked at a particular stage of the GC re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0f2960b38357ae56f03e9ff48e3528
https://hal-amu.archives-ouvertes.fr/hal-01858136

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Single-Cell RNA Sequencing Identifies a Pseudo-Immune Differentiation Axis As the Main Source of Functional Heterogeneity in Follicular Lymphoma B-Cells

Autor: Bertrand Nadel, Laurine Gil, Chuang Dong, Noudjoud Attaf, Jean-Marc Navarro, Lionel Spinelli, Pierre Milpied, Inaki Cervera-Marzal

Publikováno v: Blood. 134:548-548

Introduction Follicular Lymphoma (FL), the second most frequent lymphoma in adults, often presents as a disseminated disease at diagnosis. Despite a generally slow progression and a median overall survival of more than 15 years with current chemo-imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c55b7a6e090fc25cc66fb23f5107cd8c
https://doi.org/10.1182/blood-2019-125718

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Desynchronization of the Germinal Center Dynamics and Remodeling of the Tumor Microenvironment Characterize KMT2D-Driven Lymphomagenesis

Autor: Caroline Laprie, Gabriel Brisou, Manon Zala, Bertrand Nadel, Lionel Chasson, Gilles Salles, Sarah Huet, Giulia Pagano, Sandrine Roulland, Delphine Potier, Agnès Bru, Sebastien Nin, Laurine Gil, Pierre Milpied, Inaki Cervera-Marzal

Publikováno v: Blood. 132:670-670

Follicular lymphoma (FL) is a prototypical example of germinal center (GC) derived B-cell lymphoma. Using a mouse model recapitulating the sporadic occurrence of the FL hallmark BCL2/IGH translocation in healthy individuals, our previous work demonst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::271a43ba5c89331b4c719cb2044767d1
https://doi.org/10.1182/blood-2018-99-116617

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High-Dimensional Single-Cell Analysis Identifies Organ-Specific Signatures and Conserved NK Cell Subsets in Humans and Mice

Autor: Pierre Milpied, Sébastien Jaeger, Inaki Cervera-Marzal, Lionel Spinelli, Eric Vivier, Justine Galluso, Sami Hamed, Sophie Ugolini, Emilie Bollon, Frédéric Vély, Anaïs Balsamo, Mikael Ebbo, Adeline Crinier, Jean Hardwigsen, Mathilde J. H. Girard-Madoux, Bertrand Escalière, Emilie Narni-Mancinelli, Christelle Piperoglou

Publikováno v: Immunity
Immunity, 2018, 49 (5), pp.971--986.e5. ⟨10.1016/j.immuni.2018.09.009⟩
Immunity, Elsevier, 2018, 49 (5), pp.971--986.e5. ⟨10.1016/j.immuni.2018.09.009⟩

Summary Natural killer (NK) cells are innate lymphoid cells (ILCs) involved in antimicrobial and antitumoral responses. Several NK cell subsets have been reported in humans and mice, but their heterogeneity across organs and species remains poorly ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d9cb0af318b408d8715dcb932f4d39

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