Reverse engineering synthetic antiviral amyloids

Autor: Emiel Michiels, Kenny Roose, Rodrigo Gallardo, Ladan Khodaparast, Laleh Khodaparast, Rob van der Kant, Maxime Siemons, Bert Houben, Meine Ramakers, Hannah Wilkinson, Patricia Guerreiro, Nikolaos Louros, Suzanne J. F. Kaptein, Lorena Itatí Ibañez, Anouk Smet, Pieter Baatsen, Shu Liu, Ina Vorberg, Guy Bormans, Johan Neyts, Xavier Saelens, Frederic Rousseau, Joost Schymkowitz

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Abstract Human amyloids have been shown to interact with viruses and interfere with viral replication. Based on this observation, we employed a synthetic biology approach in which we engineered virus-specific amyloids against influenza A and Zika pro

Externí odkaz: https://doaj.org/article/ffcec336575043bba6212cbf4b6b3b72

Extracellular Vesicle Separation Techniques Impact Results from Human Blood Samples: Considerations for Diagnostic Applications

Autor: Theophilos Tzaridis, Daniel Bachurski, Shu Liu, Kristin Surmann, Felix Babatz, Manuela Gesell Salazar, Uwe Völker, Michael Hallek, Ulrich Herrlinger, Ina Vorberg, Christoph Coch, Katrin S. Reiners, Gunther Hartmann

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 17, p 9211 (2021)

Extracellular vesicles (EVs) are reminiscent of their cell of origin and thus represent a valuable source of biomarkers. However, for EVs to be used as biomarkers in clinical practice, simple, comparable, and reproducible analytical methods must be a

Externí odkaz: https://doaj.org/article/1a448b98f650422a907d11fe166ed025

Viruses in neurodegenerative diseases: More than just suspects in crimes

Autor: Pascal Leblanc, Ina Vorberg

Publikováno v: PLoS pathogens 18(8), e1010670 (2022). doi:10.1371/journal.ppat.1010670

Neurodegenerative diseases (NDs) such as Alzheimer’s and Parkinson’s disease are fatal neurological diseases that can be of idiopathic, genetic, or even infectious origin, as in the case of transmissible spongiform encephalopathies. The etiologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2871fc9956f0e96095e7565da607f7e5
https://doi.org/10.1371/journal.ppat.1010670

Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils

Autor: Riza Dervisoglu, Pijush Chakraborty, Markus Zweckstetter, Ina Vorberg, Loren B. Andreas, Alina Hebestreit, Alain Ibáñez de Opakua, Shu Liu, Gwladys Rivière

Publikováno v: Nature Communications 12(1), 4231 (2021). doi:10.1038/s41467-021-24362-8
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Pathological aggregation of the protein tau into insoluble aggregates is a hallmark of neurodegenerative diseases. The emergence of disease-specific tau aggregate structures termed tau strains, however, remains elusive. Here we show that full-length

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a2adfb323aa4846b3a4d5a77b50e06
https://pub.dzne.de/record/155435

Extracellular Vesicle Separation Techniques Impact Results from Human Blood Samples: Considerations for Diagnostic Applications

Autor: Felix Babatz, Ina Vorberg, Daniel Bachurski, Uwe Völker, Theophilos Tzaridis, Kristin Surmann, Manuela Gesell Salazar, Katrin S Reiners, Shu Liu, Ulrich Herrlinger, Michael Hallek, Gunther Hartmann, Christoph Coch

Publikováno v: International journal of molecular sciences 22(17), 9211 (2021). doi:10.3390/ijms22179211 special issue: "Circulating Molecules and Precision Medicine in Cancer"
International Journal of Molecular Sciences
Volume 22
Issue 17
International Journal of Molecular Sciences, Vol 22, Iss 9211, p 9211 (2021)

Extracellular vesicles (EVs) are reminiscent of their cell of origin and thus represent a valuable source of biomarkers. However, for EVs to be used as biomarkers in clinical practice, simple, comparable, and reproducible analytical methods must be a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c439b76927c07427fef085ebbaccc48b