Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ina Thielmann"'
Autor:
Peter J. Noy, Rebecca L. Gavin, Dario Colombo, Elizabeth J. Haining, Jasmeet S. Reyat, Holly Payne, Ina Thielmann, Adam B. Lokman, Georgiana Neag, Jing Yang, Tammy Lloyd, Neale Harrison, Victoria L. Heath, Chris Gardiner, Katharine M. Whitworth, Joseph Robinson, Chek Z. Koo, Alessandro Di Maio, Paul Harrison, Steven P. Lee, Francesco Michelangeli, Neena Kalia, G. Ed Rainger, Bernhard Nieswandt, Alexander Brill, Steve P. Watson, Michael G. Tomlinson
Publikováno v:
Haematologica, Vol 104, Iss 9 (2019)
Ca2+ entry via Orai1 store-operated Ca2+ channels in the plasma membrane is critical to cell function, and Orai1 loss causes severe immunodeficiency and developmental defects. The tetraspanins are a superfamily of transmembrane proteins that interact
Externí odkaz:
https://doaj.org/article/72942b750efd4ee2a4e3fd070b4f38e4
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133429 (2015)
Integrin αIIbβ3 plays a central role in the adhesion and aggregation of platelets and thus is essential for hemostasis and thrombosis. Integrin activation requires the transmission of a signal from the small cytoplasmic tails of the α or β subuni
Externí odkaz:
https://doaj.org/article/0b51a4a7d19e4710ae5bb4c365095b7f
Autor:
Katharine Whitworth, Paul Harrison, Georgiana Neag, Neale Harrison, Chek Ziu Koo, Michael G. Tomlinson, Alexander Brill, Rebecca L. Gavin, G. Ed Rainger, Adam B. Lokman, Elizabeth J. Haining, Dario Colombo, Jasmeet S. Reyat, Steve P. Watson, Steven P. Lee, Jing Yang, Francesco Michelangeli, Neena Kalia, Bernhard Nieswandt, Victoria L. Heath, Alessandro Di Maio, Holly Payne, Joseph Robinson, Peter J. Noy, Ina Thielmann, Chris Gardiner, Tammy Lloyd
Publikováno v:
Haematologica
Ca2+ entry via Orai1 store-operated Ca2+ channels in the plasma membrane is critical to cell function, and Orai1 loss causes severe immunodeficiency and developmental defects. The tetraspanins are a superfamily of transmembrane proteins that interact
Autor:
Eva Göb, Kerstin Göbel, Stephan Reymann, Marc Brede, Christian Geis, Bernhard Nieswandt, Christoph Kleinschnitz, Guido Stoll, Sven G. Meuth, Peter Kraft, György A. Homola, Ina Thielmann, Laszlo Solymosi, Michael K. Schuhmann, Friederike Langhauser
Publikováno v:
Annals of Neurology. 77:784-803
Objective Recent evidence suggests that ischemic stroke is a thromboinflammatory disease. Plasma kallikrein (PK) cleaves high–molecular-weight kininogen to release bradykinin (BK) and is a key constituent of the proinflammatory contact-kinin system
Publikováno v:
Journal of Thrombosis and Haemostasis. 12:1364-1371
Summary Background Blood platelets are small anucleated cell fragments generated from bone marrow megakaryocytes (MKs) by a cytoskeleton-driven process. Thereby, mature MKs form long cytoplasmic protrusions (pro-platelets), which extend into the sinu
Autor:
Ina Thielmann, Bernhard Nieswandt, David Stegner, Guido Stoll, Michael A. Frohman, Peter Kraft
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33:2212-2217
Objective— We recently showed that mice lacking the lipid signaling enzyme phospholipase (PL) D1 or both PLD isoforms (PLD1 and PLD2) were protected from pathological thrombus formation and ischemic stroke, whereas hemostasis was not impaired in th
Autor:
Beate Eckes, Peter Kraft, Jan-Niklas Schulz, Sebastian Dütting, Ina Thielmann, Sabine A. Eming, Guido Stoll, Timo Vögtle, Deya Cherpokova, David Stegner, Bernhard Nieswandt, Carsten Deppermann, Christoph Kleinschnitz, Georg Krohne, Alan T. Nurden, Paquita Nurden
Publikováno v:
Journal of Clinical Investigation. 123:3331-3342
Platelets are anuclear organelle-rich cell fragments derived from bone marrow megakaryocytes (MKs) that safeguard vascular integrity. The major platelet organelles, α-granules, release proteins that participate in thrombus formation and hemostasis.
Autor:
Frauke May, Ina Hagedorn, Timo Vögtle, Brenda A. Finney, Michael R. Bösl, Steve P. Watson, Markus Bender, Katharina A. Remer, Attila Braun, Viola Lorenz, Ina Thielmann, Bernhard Nieswandt
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33:926-934
Objective— Platelet inhibition is a major strategy to prevent acute ischemic cardiovascular and cerebrovascular events, which may, however, be associated with an increased bleeding risk. The (hem)immunoreceptor tyrosine activation motif–bearing p
Autor:
Ruben Böhmer, Ina Thielmann, Bernhard Nieswandt, Jan Prodöhl, Friedemann Kiefer, Vanessa Weis, Theresa Schumacher, Judith M.M. van Eeuwijk, Martin Andreas, Sebastian Königsberger, Martin Stehling, David Stegner
Publikováno v:
The EMBO Journal. 31:3363-3374
The spleen tyrosine kinase family members Syk and Zap-70 are pivotal signal transducers downstream of antigen receptors and exhibit overlapping expression patterns at early lymphocytic developmental stages. To assess their differential kinase fitness
Autor:
Irina Pleines, Alexander Dietrich, Bernhard Nieswandt, Ina Thielmann, Attila Braun, G. Ramanathan, Shuchi Gupta, Frauke May, Christine Mannhalter, David Varga-Szabo
Publikováno v:
Journal of Thrombosis and Haemostasis. 10:419-429
Summary. Background: Platelet adhesion, activation and aggregation at sites of vascular injury are essential processes for primary hemostasis. Elevation of the intracellular Ca2+ concentration is a central event in platelet activation but the underly