Medial Temporal Lobe Atrophy in Predementia Alzheimer’s Disease: A Longitudinal Multi-Site Study Comparing Staging and A/T/N in a Clinical Research Cohort

Autor: Jonas Alexander Jarholm, Atle Bjørnerud, Turi Olene Dalaker, Mehdi Sadat Akhavi, Bjørn Eivind Kirsebom, Lene Pålhaugen, Kaja Nordengen, Gøril Rolfseng Grøntvedt, Arne Nakling, Lisa F. Kalheim, Ina S. Almdahl, Sandra Tecelão, Tormod Fladby, Per Selnes

Publikováno v: Journal of Alzheimer's Disease. :1-21

Background: Atrophy of the medial temporal lobe (MTL) is a biological characteristic of Alzheimer’s disease (AD) and can be measured by segmentation of magnetic resonance images (MRI). Objective: To assess the clinical utility of automated volumetr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1dbdce8915b44010550984190c3c338
https://doi.org/10.3233/jad-221274

Inhibition of emotions in healthy aging: age‐related differences in brain network connectivity

Autor: Ina S. Almdahl, Liva J. Martinussen, Ingrid Agartz, Kenneth Hugdahl, Maria S. Korsnes

Publikováno v: Brain and Behavior, Vol 11, Iss 5, Pp n/a-n/a (2021)

Abstract Introduction Successful inhibition of distracting emotions is important for preserving well‐being and daily functioning. There is conflicting evidence regarding the impact of healthy aging on emotional inhibition, and possible age‐relate

Externí odkaz: https://doaj.org/article/5e71312a5ec04ec1a7d804b0f9032fb9

Brain pathology and cognitive scores prior to onset of late-life depression

Autor: Ina S, Almdahl, Ingrid, Agartz, Kenneth, Hugdahl, Maria S, Korsnes

Publikováno v: International journal of geriatric psychiatryREFERENCES. 37(3)

Understanding the biological changes that occur prior to onset of late-life depression (LLD) is key to its prevention. To investigate potential predictors of LLD, we assessed cognitive scores and neurodegenerative and vascular biomarkers in healthy o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf6d0d851f3329885246eecdde98ce8e
https://pubmed.ncbi.nlm.nih.gov/35178780

Detecting At-Risk Alzheimer’s Disease Cases

Autor: Arne Nakling, Knut Waterloo, Kjell Arne Arntzen, Ragna Espenes, Sandra R.R. Tecelão, Svein Ivar Bekkelund, Carl Fredrik Eliassen, Kai Ivar Müller, Gøril Rolfseng Grøntvedt, Lene Pålhaugen, Lisa Flem Kalheim, Bjørn-Eivind Kirsebom, Ina S. Almdahl, Geir Bråthen, Krisztina Kunszt Johansen, Ramune Grambaite, Dag Aarsland, Ane Løvli Stav, Stein Harald Johnsen, Arvid Rongve, Per Selnes, Sigrid Botne Sando, Nikias Siafarikas, Erik Hessen, Tormod Fladby, Eirik Auning, Santiago Timón

Publikováno v: Fladby, T, Palhaugen, L, Selnes, P, Waterloo, K, Brathen, G, Hessen, E, Almdahl, I S, Arntzen, K-A, Auning, E, Eliassen, C F, Espenes, R, Grambaite, R, Grontvedt, G R, Johansen, K K, Johnsen, S H, Kalheim, L F, Kirsebom, B-E, Muller, K I, Nakling, A E, Rongve, A, Sando, S B, Siafarikas, N, Stav, A L, Tecelao, S, Timon, S, Bekkelund, S I & Aarsland, D 2017, ' Detecting At-Risk Alzheimer's Disease Cases ', JOURNAL OF ALZHEIMERS DISEASE, vol. 60, no. 1, pp. 97-105 . https://doi.org/10.3233/JAD-170231
Journal of Alzheimer's Disease

While APOE ɛ4 is the major genetic risk factor for Alzheimer’s disease (AD), amyloid dysmetabolism is an initial or early event predicting clinical disease and is an important focus for secondary intervention trials. To improve identification of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a7d7730607572baca51c6bb6c94568
https://doi.org/10.3233/jad-170231

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

Autor: Julia Sealock, Linda R. White, John Hardy, Geir Bråthen, Danielle Posthuma, Christiaan de Leeuw, Ingvild Saltvedt, Julien Bryois, Lea K. Davis, Timothy J. Hohman, Logan Dumitrescu, Nancy L. Pedersen, Petroula Proitsi, Francesco Bettella, Eystein Stordal, Dylan M. Williams, Sigrid Botne Sando, Sven Stringer, Stacy Steinberg, Jon Snaedal, Steven J. Kiddle, Jens Hjerling-Leffler, Fred Andersen, Ida K. Karlsson, Yunpeng Wang, Palmi V. Jonsson, Nicola Voyle, Jeanne E. Savage, Ingun Ulstein, Stephan Ripke, Richard Dobson, Anne Brækhus, Arvid Rongve, Sverre Bergh, Hreinn Stefansson, Dag Aarsland, Kyoko Watanabe, Patrick F. Sullivan, Maryam Shoai, Geir Selbæk, Sigurbjorn Bjornsson, Rahul S. Desikan, Srdjan Djurovic, Ina S. Almdahl, Sara Hägg, Kari Stefansson, Lavinia Athanasiu, Nathan G. Skene, Aree Witoelar, Iris E. Jansen, Ole A. Andreassen, Wiesje M. van der Flier, Tormod Fladby

Publikováno v: Nature Genetics, 51(3), 404-413. Nature Publishing Group
Jansen, I E, Savage, J E, Watanabe, K, Bryois, J, Williams, D M, Steinberg, S, Sealock, J, Karlsson, I K, Hägg, S, Athanasiu, L, Voyle, N, Proitsi, P, Witoelar, A, Stringer, S, Aarsland, D, Almdahl, I S, Andersen, F, Bergh, S, Bettella, F, Bjornsson, S, Brækhus, A, Bråthen, G, de Leeuw, C, Desikan, R S, Djurovic, S, Dumitrescu, L, Fladby, T, Hohman, T J, Jonsson, P V, Kiddle, S J, Rongve, A, Saltvedt, I, Sando, S B, Selbæk, G, Shoai, M, Skene, N G, Snaedal, J, Stordal, E, Ulstein, I D, Wang, Y, White, L R, Hardy, J, Hjerling-Leffler, J, Sullivan, P F, van der Flier, W M, Dobson, R, Davis, L K, Stefansson, H, Stefansson, K, Pedersen, N L, Ripke, S, Andreassen, O A & Posthuma, D 2019, ' Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk ', Nature Genetics, vol. 51, no. 3, pp. 404-413 . https://doi.org/10.1038/s41588-018-0311-9
Jansen, I E, Savage, J E, Watanabe, K, Bryois, J, Williams, D M, Steinberg, S, Sealock, J, Karlsson, I K, Hägg, S, Athanasiu, L, Voyle, N, Proitsi, P, Witoelar, A, Stringer, S, Aarsland, D, Almdahl, I S, Andersen, F, Bergh, S, Bettella, F, Bjornsson, S, Brækhus, A, Bråthen, G, de Leeuw, C, Desikan, R S, Djurovic, S, Dumitrescu, L, Fladby, T, Hohman, T J, Jonsson, P V, Kiddle, S J, Rongve, A, Saltvedt, I, Sando, S B, Selbæk, G, Shoai, M, Skene, N G, Snaedal, J, Stordal, E, Ulstein, I D, Wang, Y, White, L R, Hardy, J, Hjerling-Leffler, J, Sullivan, P F, van der Flier, W M, Dobson, R, Davis, L K, Stefansson, H, Stefansson, K, Pedersen, N L, Ripke, S, Andreassen, O A & Posthuma, D 2019, ' Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk ', Nature Genetics, vol. 51, no. 3, pp. 404-413 . https://doi.org/10.1038/s41588-018-0311-9
Nature Genetics

Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci remain. Here, we performed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a962a380017ba61e1af21ea26eff5ad6
https://research.vumc.nl/en/publications/8c0567cc-6ec7-4649-a3f5-8b4da2a5f679