Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Ina Rothenaigner"'
Autor:
Juliane Tschuck, Vidya Padmanabhan Nair, Ana Galhoz, Carole Zaratiegui, Hin-Man Tai, Gabriele Ciceri, Ina Rothenaigner, Jason Tchieu, Brent R. Stockwell, Lorenz Studer, Daphne S. Cabianca, Michael P. Menden, Michelle Vincendeau, Kamyar Hadian
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The development of functional neurons is a complex orchestration of multiple signaling pathways controlling cell proliferation and differentiation. Because the balance of antioxidants is important for neuronal survival and development, we hy
Externí odkaz:
https://doaj.org/article/444c8caf5d9e4924ae0ce2d1e59fd94d
Autor:
Juliane Tschuck, Lea Theilacker, Ina Rothenaigner, Stefanie A. I. Weiß, Banu Akdogan, Van Thanh Lam, Constanze Müller, Roman Graf, Stefanie Brandner, Christian Pütz, Tamara Rieder, Philippe Schmitt-Kopplin, Michelle Vincendeau, Hans Zischka, Kenji Schorpp, Kamyar Hadian
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Ferroptosis is a regulated cell death modality that occurs upon iron-dependent lipid peroxidation. Recent research has identified many regulators that induce or inhibit ferroptosis; yet, many regulatory processes and networks remain to be el
Externí odkaz:
https://doaj.org/article/c8879d0735a7477fa4fa2036c2269a28
Autor:
Kenji Schorpp, Alaa Bessadok, Aidin Biibosunov, Ina Rothenaigner, Stefanie Strasser, Tingying Peng, Kamyar Hadian
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Cell death, such as apoptosis and ferroptosis, play essential roles in the process of development, homeostasis, and pathogenesis of acute and chronic diseases. The increasing number of studies investigating cell death types in various diseas
Externí odkaz:
https://doaj.org/article/7296be3587b140738cb54ee5ac7603f8
Autor:
Goetz Hartleben, Kenji Schorpp, Yun Kwon, Barbara Betz, Foivos‐Filippos Tsokanos, Zahra Dantes, Arlett Schäfer, Ina Rothenaigner, José Manuel Monroy Kuhn, Pauline Morigny, Lisa Mehr, Sean Lin, Susanne Seitz, Janina Tokarz, Anna Artati, Jerzy Adamsky, Oliver Plettenburg, Dominik Lutter, Martin Irmler, Johannes Beckers, Maximilian Reichert, Kamyar Hadian, Anja Zeigerer, Stephan Herzig, Mauricio Berriel Diaz
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 4, Pp 1-21 (2021)
Abstract By accentuating drug efficacy and impeding resistance mechanisms, combinatorial, multi‐agent therapies have emerged as key approaches in the treatment of complex diseases, most notably cancer. Using high‐throughput drug screens, we uncov
Externí odkaz:
https://doaj.org/article/5b69fc35368c4378aea983eb723c06a2
Autor:
Doris Maugg, Ina Rothenaigner, Kenji Schorpp, Harish Kumar Potukuchi, Eberhard Korsching, Daniel Baumhoer, Kamyar Hadian, Jan Smida, Michaela Nathrath
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129058 (2015)
Despite the option of multimodal therapy in the treatment strategies of osteosarcoma (OS), the most common primary malignant bone tumor, the standard therapy has not changed over the last decades and still involves multidrug chemotherapy and radical
Externí odkaz:
https://doaj.org/article/21b6f33aaf7e4b599c0bb134fee6d4aa
Autor:
Juliane Tschuck, Vidya Padmanabhan Nair, Ana Galhoz, Gabriele Ciceri, Ina Rothenaigner, Jason Tchieu, Hin-Man Tai, Brent R. Stockwell, Lorenz Studer, Michael P. Menden, Michelle Vincendeau, Kamyar Hadian
SummaryDevelopment of functional neurons is a complex orchestration of several signaling pathways controlling cell proliferation, differentiation, and homeostasis1. However, details about the involved factors are not fully understood. The balance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bfa8532fbfe3691ada6e4d7b5d45e6d
https://doi.org/10.1101/2023.04.05.535746
https://doi.org/10.1101/2023.04.05.535746
Autor:
Juliane Tschuck, Lea Theilacker, Ina Rothenaigner, Stefanie A. I. Weiß, Banu Akdogan, Constanze Müller, Roman Graf, Stefanie Brandner, Christian Pütz, Tamara Rieder, Philippe Schmitt-Kopplin, Hans Zischka, Kenji Schorpp, Kamyar Hadian
ObjectiveFerroptosis is a regulated cell death modality that occurs upon iron-dependent lipid peroxidation. The recent decade of research has uncovered many regulators driving ferroptosis as well as cellular gatekeepers preventing ferroptosis. Yet, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ecec75cdce1cda64eeb536fc22db3b6
https://doi.org/10.1101/2022.10.07.511245
https://doi.org/10.1101/2022.10.07.511245
Autor:
Maria Forstner, Sean Lin, Xiaohua Yang, Susanna Kinting, Ina Rothenaigner, Kenji Schorpp, Yang Li, Kamyar Hadian, Matthias Griese
Publikováno v:
Am. J. Respir. Cell Mol. Biol. 66, 382-390 (2022)
ABCA3 (ATP-binding cassette subfamily A member 3) is a lipid transporter expressed in alveolar type II cells and localized in the limiting membrane of lamellar bodies. It is crucial for pulmonary surfactant storage and homeostasis. Mutations in the A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689e98be4ba3135f9b6cc6337b6f1a62
https://doi.org/10.1055/s-0042-1754515
https://doi.org/10.1055/s-0042-1754515
Autor:
Kamyar Hadian, Ina Rothenaigner
Publikováno v:
Slas Discovery
SLAS Discov. 26, 851-854 (2021)
SLAS Discov. 26, 851-854 (2021)
Small-molecule screening is a powerful approach to identify modulators of either specific biological targets or cellular pathways with phenotypic endpoints. A myriad of assay technologies are available to assess the activity of enzymes, monitor prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72764cfd7120e12077b9e02704b8797c
http://europepmc.org/articles/PMC8293735
http://europepmc.org/articles/PMC8293735
Autor:
J. Willem M. Nissink, Jonathan B. Baell, Francis S. Willard, Ina Rothenaigner, Jonathan Z. Sexton, Douglas S. Auld, Jayme L. Dahlin, John Strelow, Michael A. Walters, Bruce K. Hua, Steve Haney, Lori Ferrins, Jarrod Walsh, Bridget K. Wagner, Jonathan A. Lee, Kamyar Hadian
Publikováno v:
Cell Chem. Bio. 28, 356-370 (2021)
Cell Chem Biol
Cell Chem Biol
Compounds that exhibit assay interference or undesirable mechanisms of bioactivity (“nuisance compounds”) are routinely encountered in cellular assays, including phenotypic and high-content screening assays. Much is known regarding compound-depen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f70a37970ff95ac15de8c8aee188c39
https://doi.org/10.1016/j.chembiol.2021.01.021
https://doi.org/10.1016/j.chembiol.2021.01.021