Výsledky vyhledávání - "Ina Rattmann"

In vivo enrichment of cytidine deaminase gene-modified hematopoietic cells by prolonged cytosine-arabinoside application

Autor: Axel Schambach, Ina Rattmann, Nico Lachmann, David A. Williams, T. Moritz, Sebastian Brennig

Publikováno v: Cytotherapy. 14:451-460

Drug-resistance genes have been explored as powerful in vivo selection markers in hematopoietic cell gene therapy, and cytidine deaminase (CDD) represents a particularly attractive candidate given the virtual absence of non-hematopoietic side-effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a841c11585ba25c25db33ee6f51dc5a
https://doi.org/10.3109/14653249.2011.646043

Zobrazit plný text záznamu

Reliable Generation of Stable High Titer Producer Cell Lines for Gene Therapy

Autor: Ursula R. Sorg, Bertram Opalka, Veronika Kleff, Ina Rattmann, Michael Flasshove, Thomas Moritz, Carsten Ludwig, Anja Feldmann

Publikováno v: Intervirology. 50:197-203

Objective: Retroviral vectors represent one of the most robust technologies for in vivo expression of heterologous gene sequences and are still the most commonly used vectors in clinical gene therapy trials. The production of high titer retroviral pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e23a0a0afbff7b38596cec667718065
https://doi.org/10.1159/000099218

Zobrazit plný text záznamu

Gene transfer of cytidine deaminase protects myelopoiesis from cytidine analogs in an in vivo murine transplant model

Autor: Siegfried Seeber, Walter Bardenheuer, Veronika Kleff, Michael Flasshove, Ursula R. Sorg, Ralf A. Hilger, Ina Rattmann, T. Moritz, Annette Brueckner, Bertram Opalka

Publikováno v: Blood. 108:2965-2971

Hematopoietic stem cell gene transfer of the drug-resistance gene cytidine deaminase (CDD) protecting cells from the cytotoxic cytidine analogs cytarabine and gemcitabine was investigated in a murine transplant model. Following transplantation of CDD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cc6c784c0aeed1becb85acf2b3739c
https://doi.org/10.1182/blood-2006-03-011734

Zobrazit plný text záznamu

Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia

Autor: Victoria Summey, Carlo M. Croce, David Z. Drew, Lars U.W. Müller, John C. Byrd, Ina Rattmann, Jose A. Cancelas, T. Moritz, Patrick Johnston, Yi Gu, David A. Williams, Abel Sanchez-Aguilera, David M. Lucas

Publikováno v: Leukemia

RhoH is a hematopoietic-specific, GTPase-deficient member of the Rho GTPase family that functions as a regulator of thymocyte development and T-cell receptor signaling by facilitating localization of zeta-chain-associated protein kinase 70 (ZAP70) to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda92db65748f137ac06518a75a08b8d
https://pubmed.ncbi.nlm.nih.gov/19847197

Zobrazit plný text záznamu

Gene therapy of beta(c)-deficient pulmonary alveolar proteinosis (beta(c)-PAP): studies in a murine in vivo model

Autor: Ina Rattmann, Christopher Poremba, Takuji Suzuki, T. Moritz, Carsten Bury, Ursula R. Sorg, Bertram Opalka, Uta Dirksen, Bruce C. Trapnell, Michael Flasshove, Veronika Kleff, Moran Jerabek-Willemsen

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy. 16(4)

Pulmonary alveolar proteinosis (PAP) due to deficiency of the common beta-chain (beta(c)) of the interleukin-3 (IL-3)/IL-5/granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors is a rare monogeneic disease characterized by functional in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9cd11f69c07d8a8e7caf4afe90e70c3
https://pubmed.ncbi.nlm.nih.gov/18334984

Zobrazit plný text záznamu

Resistance to cytarabine and gemcitabine and in vitro selection of transduced cells after retroviral expression of cytidine deaminase in human hematopoietic progenitor cells

Autor: A Brueckner, Siegfried Seeber, T. Moritz, K Lehmberg, Walter Bardenheuer, Ina Rattmann, Ursula R. Sorg, Michael Flasshove, A. Schneider

Publikováno v: Leukemia. 19(12)

Overexpression of the detoxifying enzyme cytidine deaminase (CDD) renders normal and leukemic hematopoietic cells resistant to cytarabine (1-beta-D-arabinofuranosylcytosine), and studies on murine cells have suggested transgenic CDD overexpression as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66f83ec5f108381427206a25bf3fb01
https://pubmed.ncbi.nlm.nih.gov/16304576

Zobrazit plný text záznamu

The Expression of the GTPase-Deficient, Hematopoietic-Specific RhoH GTPase Is Implicated in Development of Chronic Lymphocytic Leukemia (CLL)

Autor: Ina Rattmann, Yi Gu, T. Moritz, David Zhu, John C. Byrd, David A. Williams, Carlo M. Croce

Publikováno v: Blood. 110:339-339

RhoH is a hematopoietic-specific small GTPase which is constitutively active due to lack of intrinsic GTPase activity, suggesting that expression levels of RhoH regulate cellular function. Our lab has previously shown that RhoH in T-cells directly in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60cd3ad09f209555abf71f634b477810
https://doi.org/10.1182/blood.v110.11.339.339

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání