Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ina Poehner"'
Publikováno v:
ACS Omega, Vol 3, Iss 6, Pp 6465-6475 (2018)
Externí odkaz:
https://doaj.org/article/0cc34c34ce874c7b87363561b8119927
Publikováno v:
Expert opinion on drug discovery. 17(9)
Trypanosomatidic parasitic infections in humans and animals caused by Trypanosoma brucei, Trypanosoma cruzi, and Leishmania species pose a significant health and economic burden in developing countries. There are few effective and accessible treatmen
Autor:
Maria Kuzikov, G. Landi, Maria Paola Costi, Nuno Santarém, Antonio Quotadamo, Cecilia Pozzi, Ina Poehner, Bernhard Ellinger, Lucia Dello Iacono, Joanna Panecka-Hofman, Stefano Mangani, Matteo Santucci, Rebecca C. Wade, Anabela Cordeiro-da-Silva, Sheraz Gul, Pasquale Linciano, Flavio Di Pisa, Rosaria Luciani, Gesa Witt, Alberto Venturelli
The optimization of compounds with multiple targets in the drug discovery cycle is a difficult multidimensional problem. Here, we present a systematic, multidisciplinary approach to the development of selective anti-parasitic compounds. Efficient mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c4b5e1556ad24e83bd22e30049ded70
https://doi.org/10.33774/chemrxiv-2021-9fpln-v3
https://doi.org/10.33774/chemrxiv-2021-9fpln-v3
Autor:
Ina Poehner, Antonio Quotadamo, Joanna Panecka-Hofman, Rosaria Luciani, Matteo Santucci, Pasquale Linciano, Giacomo Landi, Flavio Di Pisa, Lucia Dello Iacono, Cecilia Pozzi, Stefano Mangani, Sheraz Gul, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Nuno Santarem, Anabela Cordeiro-da-Silva, Maria Paola Costi, Alberto Venturelli, Rebecca Wade
The optimization of compounds with multiple targets in the drug discovery cycle is a difficult multidimensional problem. Here, we present a systematic, multidisciplinary approach to the development of selective anti-parasitic compounds. Efficient mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30b02979f590c77a9b2cdd1a191bd33
https://doi.org/10.26434/chemrxiv.13026797.v2
https://doi.org/10.26434/chemrxiv.13026797.v2
Publikováno v:
ACS Omega
ACS Omega, Vol 3, Iss 6, Pp 6465-6475 (2018)
ACS Omega, Vol 3, Iss 6, Pp 6465-6475 (2018)
MCMap is a tool particularly well-suited for analyzing energy landscapes of transient macromolecular complexes. The program applies a Monte Carlo strategy, where the ligand moves randomly in the electrostatic field of the receptor. By applying import
Autor:
Paloma Tejera Nevado, Anabela Cordeiro-da-Silva, María Jesús Corral, Gesa Witt, Catarina Baptista, Rebecca C. Wade, G. Landi, José Mª Alunda, Juan J. Torrado, Bernhard Ellinger, Maria Kuzikov, Maria Paola Costi, Julia Eick, Stefano Mangani, Jeanette Reinshagen, Eugenia Bifeld, Nuno Santarém, Sheraz Gul, Manfred Kohler, Stefania Ferrari, Joachim Clos, María Dolores Jiménez-Antón, Lucia Dello Iacono, Birte Behrens, Philip Gribbon, Cecilia Pozzi, Oliver Keminer, Markus Wolf, Luca Costantino, Stefan Henrich, Matteo Trande, Rosaria Luciani, Ina Poehner, Flavio Di Pisa, Annalisa Tait, Federica Pellati, Chiara Borsari
Publikováno v:
'Journal of Medicinal Chemistry ', vol: 59, pages: 7598-7616 (2016)
Flavonoids represent a potential source of new antitrypanosomatidic leads. Starting from a library of natural products, we combined target-based screening on pteridine reductase 1 with phenotypic screening on Trypanosoma brucei for hit identification