Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Ina Oehme"'
Autor:
Lisa Rösch, Sonja Herter, Sara Najafi, Johannes Ridinger, Heike Peterziel, Jindrich Cinatl, David T. W. Jones, Martin Michaelis, Olaf Witt, Ina Oehme
Publikováno v:
Molecular Oncology, Vol 17, Iss 1, Pp 37-58 (2023)
Chemotherapy resistance is a persistent clinical problem in relapsed high‐risk neuroblastomas. We tested a panel of 15 drugs for sensitization of neuroblastoma cells to the conventional chemotherapeutic vincristine, identifying tariquidar, an inhib
Externí odkaz:
https://doaj.org/article/0cc0e9cead214d9db95d54cee9506c3a
Autor:
Heike Peterziel, Nora Jamaladdin, Dina ElHarouni, Xenia F. Gerloff, Sonja Herter, Petra Fiesel, Yannick Berker, Mirjam Blattner-Johnson, Kathrin Schramm, Barbara C. Jones, David Reuss, Laura Turunen, Aileen Friedenauer, Tim Holland-Letz, Martin Sill, Lena Weiser, Christopher Previti, Gnanaprakash Balasubramanian, Nicolas U. Gerber, Johannes Gojo, Caroline Hutter, Ingrid Øra, Olli Lohi, Antonis Kattamis, Bram de Wilde, Frank Westermann, Stephan Tippelt, Norbert Graf, Michaela Nathrath, Monika Sparber-Sauer, Astrid Sehested, Christof M. Kramm, Uta Dirksen, Olli Kallioniemi, Stefan M. Pfister, Cornelis M. van Tilburg, David T. W. Jones, Jani Saarela, Vilja Pietiäinen, Natalie Jäger, Matthias Schlesner, Annette Kopp-Schneider, Sina Oppermann, Till Milde, Olaf Witt, Ina Oehme
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-17 (2022)
Abstract The international precision oncology program INFORM enrolls relapsed/refractory pediatric cancer patients for comprehensive molecular analysis. We report a two-year pilot study implementing ex vivo drug sensitivity profiling (DSP) using a li
Externí odkaz:
https://doaj.org/article/d21634f309aa434aa0d7808304d8ec37
Autor:
Niklas Jänsch, Christian Meyners, Marius Muth, Aleksandra Kopranovic, Olaf Witt, Ina Oehme, Franz-Josef Meyer-Almes
Publikováno v:
Redox Biology, Vol 20, Iss , Pp 60-67 (2019)
Enzymes from the histone deacetylase (HDAC) family are highly regulated by different mechanisms. However, only very limited knowledge exists about the regulation of HDAC8, an established target in multiple types of cancer. A previous dedicated study
Externí odkaz:
https://doaj.org/article/3088a401f7554e9da2f7cf94a0f928c1
Autor:
Salma Darwish, Ehab Ghazy, Tino Heimburg, Daniel Herp, Patrik Zeyen, Rabia Salem-Altintas, Johannes Ridinger, Dina Robaa, Karin Schmidtkunz, Frank Erdmann, Matthias Schmidt, Christophe Romier, Manfred Jung, Ina Oehme, Wolfgang Sippl
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7535 (2022)
In addition to involvement in epigenetic gene regulation, histone deacetylases (HDACs) regulate multiple cellular processes through mediating the activity of non-histone protein substrates. The knockdown of HDAC8 isozyme is associated with the inhibi
Externí odkaz:
https://doaj.org/article/66232e6fc4624caa9371a7968efca1bb
Autor:
Charlotte Gatzweiler, Johannes Ridinger, Sonja Herter, Xenia F. Gerloff, Dina ElHarouni, Yannick Berker, Roland Imle, Lukas Schmitt, Sina Kreth, Sabine Stainczyk, Simay Ayhan, Sara Najafi, Damir Krunic, Karen Frese, Benjamin Meder, David Reuss, Petra Fiesel, Kathrin Schramm, Mirjam Blattner-Johnson, David T. W. Jones, Ana Banito, Frank Westermann, Sina Oppermann, Till Milde, Heike Peterziel, Olaf Witt, Ina Oehme
Publikováno v:
Cancers, Vol 14, Iss 3, p 849 (2022)
The survival rate among children with relapsed tumors remains poor, due to tumor heterogeneity, lack of directly actionable tumor drivers and multidrug resistance. Novel personalized medicine approaches tailored to each tumor are urgently needed to i
Externí odkaz:
https://doaj.org/article/cd782fa9988147faa25f5712c6e4facb
Autor:
Michael Müller, Lisa Rösch, Sara Najafi, Charlotte Gatzweiler, Johannes Ridinger, Xenia F. Gerloff, David T. W. Jones, Jochen Baßler, Sina Kreth, Sabine Stainczyk, Karen Frese, Benjamin Meder, Frank Westermann, Till Milde, Heike Peterziel, Olaf Witt, Ina Oehme
Publikováno v:
Cancers, Vol 13, Iss 17, p 4476 (2021)
APR-246 (Eprenetapopt/PRIMA-1Met) is a very potent anti-cancer drug in clinical trials and was initially developed as a p53 refolding agent. As an alternative mode of action, the elevation of reactive oxygen species (ROS) has been proposed. Through a
Externí odkaz:
https://doaj.org/article/4ce7352813a94cf9a0e11429e771f448
Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma
Autor:
Katharina Körholz, Johannes Ridinger, Damir Krunic, Sara Najafi, Xenia F. Gerloff, Karen Frese, Benjamin Meder, Heike Peterziel, Silvia Vega-Rubin-de-Celis, Olaf Witt, Ina Oehme
Publikováno v:
Cells, Vol 10, Iss 5, p 1001 (2021)
Depending on context and tumor stage, deregulation of autophagy can either suppress tumorigenesis or promote chemoresistance and tumor survival. Histone deacetylases (HDACs) can modulate autophagy; however, the exact mechanisms are not fully understo
Externí odkaz:
https://doaj.org/article/87ecc03626b04d9fb7aef1cb74b7d2f5
Autor:
Jagoda K Wrobel, Sara Najafi, Simay Ayhan, Charlotte Gatzweiler, Damir Krunic, Johannes Ridinger, Till Milde, Frank Westermann, Heike Peterziel, Benjamin Meder, Martin Distel, Olaf Witt, Ina Oehme
Publikováno v:
Pharmaceuticals, Vol 13, Iss 11, p 345 (2020)
The survival rate among children with relapsed neuroblastomas continues to be poor, and thus new therapeutic approaches identified by reliable preclinical drug testing models are urgently needed. Zebrafish are a powerful vertebrate model in preclinic
Externí odkaz:
https://doaj.org/article/0a80b429e7b1442ebdc55fbcdaf9c3ae
Publikováno v:
Cells, Vol 4, Iss 2, Pp 135-168 (2015)
The exploitation of autophagy by some cancer entities to support survival and dodge death has been well-described. Though its role as a constitutive process is important in normal, healthy cells, in the milieu of malignantly transformed and highly pr
Externí odkaz:
https://doaj.org/article/887661e4fc1048acaa57b7eb4d444401
Autor:
Yannick Berker, Dina ElHarouni, Heike Peterziel, Petra Fiesel, Olaf Witt, Ina Oehme, Matthias Schlesner, Sina Oppermann
Publikováno v:
IEEE Transactions on Medical Imaging. 41:3981-3999
Image-based phenotypic drug profiling is receiving increasing attention in drug discovery and precision medicine. Compared to classical end-point measurements quantifying drug response, image-based profiling enables both the quantification of drug re