Longitudinal tracking of acute kidney injury reveals injury propagation along the nephron

Autor: Luca Bordoni, Anders M. Kristensen, Donato Sardella, Hanne Kidmose, Layla Pohl, Søren Rasmus Palmelund Krag, Ina Maria Schiessl

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Abstract Acute kidney injury (AKI) is an important risk factor for chronic kidney disease (CKD), but the underlying mechanisms of failed tubule repair and AKI-CKD transition are incompletely understood. In this study, we aimed for dynamic tracking of

Externí odkaz: https://doaj.org/article/d284609e962448868a2eb4845c8462cd

Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice

Autor: Hans I-Chen Harn, Sheng-Pei Wang, Yung-Chih Lai, Ben Van Handel, Ya-Chen Liang, Stephanie Tsai, Ina Maria Schiessl, Arijita Sarkar, Haibin Xi, Michael Hughes, Stefan Kaemmer, Ming-Jer Tang, Janos Peti-Peterdi, April D. Pyle, Thomas E. Woolley, Denis Evseenko, Ting-Xin Jiang, Cheng-Ming Chuong

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

How hair follicle regeneration arises readily in some species ie. spiny rather than laboratory mice, is unclear. Here, authors compare them, showing an optimal stiffness is needed for placode formation and the difference in hair follicle regenerative

Externí odkaz: https://doaj.org/article/c7529f01880d4450966fe241daf10441

Serial intravital imaging captures dynamic and functional endothelial remodeling with single-cell resolution

Autor: Dorinne Desposito, Ina Maria Schiessl, Georgina Gyarmati, Anne Riquier-Brison, Audrey K. Izuhara, Hiroyuki Kadoya, Balint Der, Urvi Nikhil Shroff, Young-Kwon Hong, Janos Peti-Peterdi

Publikováno v: JCI Insight, Vol 6, Iss 10 (2021)

Endothelial cells are important in the maintenance of healthy blood vessels and in the development of vascular diseases. However, the origin and dynamics of endothelial precursors and remodeling at the single-cell level have been difficult to study i

Externí odkaz: https://doaj.org/article/f6a4216dccbe48c283a43ea95e681fdf

Superficial nephrons in BALB/c and C57BL/6 mice facilitate in vivo multiphoton microscopy of the kidney.

Autor: Ina Maria Schießl, Sophia Bardehle, Hayo Castrop

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e52499 (2013)

Multiphoton microscopy (MPM) offers a unique approach for addressing both the function and structure of an organ in near-real time in the live animal. The method however is limited by the tissue-specific penetration depth of the excitation laser. In

Externí odkaz: https://doaj.org/article/3d2e4bc314094ebda6a86e218b7956a5

A Founder Mutation in

Autor: Naomi Issler, Sara Afonso, Irith Weissman, Katrin Jordan, Alberto Cebrian-Serrano, Katrin Meindl, Eileen Dahlke, Konstantin Tziridis, Guanhua Yan, José M. Robles-López, Lydia Tabernero, Vaksha Patel, Anne Kesselheim, Enriko D. Klootwijk, Horia C. Stanescu, Simona Dumitriu, Daniela Iancu, Mehmet Tekman, Monika Mozere, Graciana Jaureguiberry, Priya Outtandy, Claire Russell, Anna-Lena Forst, Christina Sterner, Elena-Sofia Heinl, Helga Othmen, Ines Tegtmeier, Markus Reichold, Ina Maria Schiessl, Katharina Limm, Peter Oefner, Ralph Witzgall, Lifei Fu, Franziska Theilig, Achim Schilling, Efrat Shuster Biton, Limor Kalfon, Ayalla Fedida, Elite Arnon-Sheleg, Ofer Ben Izhak, Daniella Magen, Yair Anikster, Holger Schulze, Christine Ziegler, Martin Lowe, Benjamin Davies, Detlef Böckenhauer, Robert Kleta, Tzipora C. Falik Zaccai, Richard Warth

Publikováno v: J Am Soc Nephrol
Issler, N, Afonso, S, Weissman, I, Jordan, K, Cebrian-Serrano, A, Meindl, K, Dahlke, E, Tziridis, K, Yan, G, Robles-López, J M, Tabernero, L, Patel, V, Kesselheim, A, Klootwijk, E D, Stanescu, H C, Dumitriu, S, Iancu, D, Tekman, M, Mozere, M, Jaureguiberry, G, Outtandy, P, Russell, C, Forst, A-L, Sterner, C, Heinl, E-S, Othmen, H, Tegtmeier, I, Reichold, M, Schiessl, I M, Limm, K, Oefner, P, Witzgall, R, Fu, L, Theilig, F, Schilling, A, Shuster Biton, E, Kalfon, L, Fedida, A, Arnon-Sheleg, E, Ben Izhak, O, Magen, D, Anikster, Y, Schulze, H, Ziegler, C, Lowe, M, Davies, B, Böckenhauer, D, Kleta, R, Falik Zaccai, T C & Warth, R 2022, ' A Founder Mutation in EHD1 Presents with Tubular Proteinuria and Deafness ', Journal of the American Society of Nephrology : JASN, vol. 33, no. 4, pp. 732-745 . https://doi.org/10.1681/ASN.2021101312

BACKGROUND: The endocytic reabsorption of proteins in the proximal tubule requires a complex machinery and defects can lead to tubular proteinuria. The precise mechanisms of endocytosis and processing of receptors and cargo are incompletely understoo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d86b9e766f0d768e9b5bfddd01c006
https://pubmed.ncbi.nlm.nih.gov/35256404