Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ina M. Vorberg"'
Autor:
Pijush Chakraborty, Gwladys Rivière, Alina Hebestreit, Alain Ibáñez de Opakua, Ina M. Vorberg, Loren B. Andreas, Markus Zweckstetter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Pathogenic aggregation of the protein tau is a hallmark of Alzheimer’s disease and several other tauopathies. Tauopathies are characterized by the deposition of specific tau isoforms as disease-related tau filament structures. The molecula
Externí odkaz:
https://doaj.org/article/77f6a7aa40ff49099ccf224aed75385a
Autor:
Shu Liu, Stefanie-Elisabeth Heumüller, André Hossinger, Stephan A. Müller, Oleksandra Buravlova, Stefan F. Lichtenthaler, Philip Denner, Ina M. Vorberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved. Evidence accumulates that endogenous retroviruses, rem
Externí odkaz:
https://doaj.org/article/59bc77799ee240d9b3249e422cd48dea
Autor:
Shu Liu, André Hossinger, Stefanie-Elisabeth Heumüller, Annika Hornberger, Oleksandra Buravlova, Katerina Konstantoulea, Stephan A. Müller, Lydia Paulsen, Frederic Rousseau, Joost Schymkowitz, Stefan F. Lichtenthaler, Manuela Neumann, Philip Denner, Ina M. Vorberg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Pathologic protein aggregates associated with neurodegenerative diseases have the ability to transmit to unaffected cells via extracellular vesicles or direct cell-to-cell contact. Here, Liu et al. show that viral glycoproteins can contribute to inte
Externí odkaz:
https://doaj.org/article/3c987601848e42e7821270559f3b20a9
Autor:
Pijush Chakraborty, Gwladys Rivière, Shu Liu, Alain Ibáñez de Opakua, Rıza Dervişoğlu, Alina Hebestreit, Loren B. Andreas, Ina M. Vorberg, Markus Zweckstetter
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The authors present a method for the conversion of full-length tau protein into seeding-competent amyloid fibrils without heparin or other negatively charged co-factors, which could be useful for studying the effects of post-translational modificatio
Externí odkaz:
https://doaj.org/article/4ae08ea82f3e4f1da86a83d9dfe205fb
Autor:
Stefanie-Elisabeth Heumüller, Annika C. Hornberger, Alina S. Hebestreit, André Hossinger, Ina M. Vorberg
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 2909 (2022)
Transmissible spongiform encephalopathies or prion disorders are fatal infectious diseases that cause characteristic spongiform degeneration in the central nervous system. The causative agent, the so-called prion, is an unconventional infectious agen
Externí odkaz:
https://doaj.org/article/336f84b94e494491954b8824ff7a08aa
Autor:
Aida Revilla-García, Cristina Fernández, María Moreno-del Álamo, Vivian de los Ríos, Ina M. Vorberg, Rafael Giraldo
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT RepA is a bacterial protein that builds intracellular amyloid oligomers acting as inhibitory complexes of plasmid DNA replication. When carrying a mutation enhancing its amyloidogenesis (A31V), the N-terminal domain (WH1) generates cytosolic
Externí odkaz:
https://doaj.org/article/a467b52c25fa4171beec31fddca98605
Autor:
Franc Llorens, Katrin Thüne, Waqas Tahir, Eirini Kanata, Daniela Diaz-Lucena, Konstantinos Xanthopoulos, Eleni Kovatsi, Catharina Pleschka, Paula Garcia-Esparcia, Matthias Schmitz, Duru Ozbay, Susana Correia, Ângela Correia, Ira Milosevic, Olivier Andréoletti, Natalia Fernández-Borges, Ina M. Vorberg, Markus Glatzel, Theodoros Sklaviadis, Juan Maria Torres, Susanne Krasemann, Raquel Sánchez-Valle, Isidro Ferrer, Inga Zerr
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-21 (2017)
Abstract Background YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by inflammatory, cancer and stem cells. Its physiological role is not completely understood but YKL-40 is elevated in the brain and cerebrospinal fluid (CSF) in
Externí odkaz:
https://doaj.org/article/ecd452e7a5af49e1a47d32c0f9339fd5
Autor:
Andrea Fehlinger, Hanna Wolf, André Hossinger, Yvonne Duernberger, Catharina Pleschka, Katrin Riemschoss, Shu Liu, Romina Bester, Lydia Paulsen, Suzette A. Priola, Martin H. Groschup, Hermann M. Schätzl, Ina M. Vorberg
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Prions are unconventional agents composed of misfolded prion protein that cause fatal neurodegenerative diseases in mammals. Prion strains induce specific neuropathological changes in selected brain areas. The mechanism of strain-specific ce
Externí odkaz:
https://doaj.org/article/13fe002f36ce4b6588374aa799d3ba3e
Autor:
Ina M. Vorberg
Publikováno v:
Viruses, Vol 11, Iss 4, p 334 (2019)
Prions are infectious β-sheet-rich protein aggregates composed of misfolded prion protein (PrPSc) that do not possess coding nucleic acid. Prions replicate by recruiting and converting normal cellular PrPC into infectious isoforms. In the same host
Externí odkaz:
https://doaj.org/article/00053dd160704a2db682c1e5a535cb81
Publikováno v:
mBio, Vol 7, Iss 4 (2016)
ABSTRACT Prions are infectious protein particles that replicate by templating their aggregated state onto soluble protein of the same type. Originally identified as the causative agent of transmissible spongiform encephalopathies, prions in yeast (Sa
Externí odkaz:
https://doaj.org/article/575fb5a91c9643c08b69cfb568e5e2da