Outbreak of vancomycin-resistant Enterococcus faecium in a haematology unit: risk factor assessment and successful control of the epidemic

Autor: Wil C. Van Der Zwet, Peter C. Huijgens, Helena H. M. Meester, Ina M. Simoons-Smit, Christina M. J. E. Vandenbroucke-Grauls, Gert Jan Timmers, Paul H. M. Savelkoul

Publikováno v: British Journal of Haematology. 116:826-833

We describe an outbreak of vancomycin-resistant Enterococcus faecium (VRE) on the haematology ward of a Dutch university hospital. After the occurrence of three consecutive cases of bacteraemia with VRE, strains were genotyped and found to be identic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b87eb7c268db03f8e29d6f26753a79b
https://doi.org/10.1046/j.0007-1048.2002.03339.x

Amphotericin B- and Fluconazole-Resistant Candida spp., Aspergillus fumigatus , and Other Newly Emerging Pathogenic Fungi Are Susceptible to Basic Antifungal Peptides

Autor: Ingrid M. Reijnders, Arie V. Nieuw Amerongen, Wim van 't Hof, Enno C. I. Veerman, Ina M. Simoons-Smit, Eva J. Helmerhorst

Publikováno v: Antimicrobial Agents and Chemotherapy. 43:702-704

The present study shows that a number of basic antifungal peptides, including human salivary histatin 5, a designed histatin analog designated dhvar4, and a peptide from frog skin, PGLa, are active against amphotericin B-resistant Candida albicans ,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722c68a6d5687efc964c6da61574587e
https://doi.org/10.1128/aac.43.3.702

Synthethic histatin analogues with broad spectrum antimicrobial acitivity

Autor: Enno C. I. Veerman, W. van't Hof, Eva J. Helmerhorst, A.V. Nieuw Amerongen, Ina M. Simoons-Smit

Publikováno v: Biochemical Journal, 326, 39-45. Portland Press Ltd.
Helmerhorst, E J, van 't Hof, W, Veerman, E C I, Simoons-Smit, A M & van Nieuw Amerongen, A 1997, ' Synthethic histatin analogues with broad spectrum antimicrobial acitivity ', Biochemical Journal, vol. 326, pp. 39-45 . https://doi.org/10.1042/bj3260039

Histatins are salivary histidine-rich cationic peptides, ranging from 7 to 38 amino acid residues in length, that exert a potent killing effect in vitro on Candida albicans. Starting from the C-terminal fungicidal domain of histatin 5 (residues 11–

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff569e9ac67b284a91b6719d37c34ae
https://research.vumc.nl/en/publications/679ff2a9-9777-4f8b-b0b8-c428580be448