Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ina Lehmphul"'
Autor:
Josef Köhrle, Ina Lehmphul, Maik Pietzner, Kostja Renko, Eddy Rijntjes, Keith Richards, João Anselmo, Mark Danielsen, Jacqueline Jonklaas
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2020)
Over the last decades, thyroid hormone metabolites (THMs) received marked attention as it has been demonstrated that they are bioactive compounds. Their concentrations were determined by immunoassay or mass-spectrometry methods. Among those metabolit
Externí odkaz:
https://doaj.org/article/67a615df115746a7ad0c5b9317b970bb
Publikováno v:
Frontiers in Endocrinology
Purpose 3-iodothyronamine (3-T1AM), a decarboxylated and deiodinated thyroid hormone metabolite, leads at pharmacological doses to hypoinsulinemia, hyperglucagonemia and hyperglycemia in vivo. As the pancreatic Langerhans islets express thyroid hormo
Autor:
Uwe Völker, Georg Homuth, Jerzy Adamski, Nele Friedrich, Ina Lehmphul, Anna Artati, Kathrin Budde, Josef Köhrle, Georg Brabant, Maik Pietzner, Henry Völzke, Gabi Kastenmüller, Matthias Nauck
Publikováno v:
Thyroid 29, 1743-1754 (2019)
Thyroid
Thyroid
Background: In numerous studies based predominantly on rodent models, administration of 3,5-diiodo-L-thyronine (3,5-T2), a metabolite of the thyroid hormones (TH) thyroxine (T4) and triiodo-L-thyronine (T3), was reported to cause beneficial health ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0961a7b09e8daca509fffa4eacf20ffd
https://mediatum.ub.tum.de/doc/1540882/document.pdf
https://mediatum.ub.tum.de/doc/1540882/document.pdf
Autor:
Jeppe Lerche la Cour, Ina Lehmphul, Birte Nygaard, Josef Köhrle, Heidi M Christensen, Jens Faber, Caroline Kistorp
Publikováno v:
The Journal of clinical endocrinology and metabolism. 104(4)
Thyroid hormone metabolites might affect the heart. The endogenous aminergic metabolite 3-iodothyronamine (T1am) reduces left ventricular ejection fraction (LVEF) in rodents.To investigate concentration of T1am and its association with LVEF and bioma
Autor:
Hannelore Daniel, Eddy Rijntjes, Tilo Wuensch, Carolin S. Hoefig, Ulrich Schweizer, Jens Mittag, Josef Köhrle, Ina Lehmphul
Publikováno v:
Endocrinology. 156:4356-4364
The endogenous metabolite 3-iodothyronamine (3-T1AM) induces strong hypothermia and bradycardia at pharmacological doses. Although its biosynthesis from thyroid hormone precursors appears likely, the sequence and sites of reactions are still controve
Autor:
Matthias Nauck, Claudia Schurmann, Henri Wallaschofski, Josef Köhrle, Marcus Dörr, Georg Brabant, Ina Lehmphul, Henry Völzke, Maik Pietzner, Nele Friedrich, Uwe Völker, René Laqua, Till Ittermann, Georg Homuth
Publikováno v:
Thyroid. 25:188-197
During the last two decades, it has become obvious that 3,5-diiodothyronine (3,5-T2), a well-known endogenous metabolite of the thyroid hormones thyroxine (T4) or triiodothyronine (T3), not only represents a simple degradation intermediate of the for
Autor:
Marcus Dörr, Frank Tost, Clemens Jürgens, Josef Köhrle, Henry Völzke, Ina Lehmphul, Till Ittermann
Publikováno v:
Thyroid. 24:1473-1478
Recent studies have shown associations of hypothyroidism with arterial blood pressure, atherosclerosis, and inflammation. Based on these pathways, there might also be an association between hypothyroidism and retinal arteriolar narrowing (RAN), a mar
Publikováno v:
Europe PubMed Central
BACKGROUND: Critical illness is hallmarked by low circulating thyroxine (T4) and triiodothyronine (T3) concentrations, in the presence of elevated reverse T3 (rT3) and low-normal thyrotropin (TSH), referred to as nonthyroidal illness (NTI). Thyroid h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620f3cc55297413b2cefc3f36c83fc86
https://lirias.kuleuven.be/handle/123456789/551508
https://lirias.kuleuven.be/handle/123456789/551508
Autor:
Eddy Rijntjes, Nancy Schanze, S Jacobi, Stefan Mergler, Jens Mittag, Heike Biebermann, Carolin S. Hoefig, Josef Köhrle, Marta del Olmo, Noushafarin Khajavi, Ina Lehmphul
Publikováno v:
Thyroid : official journal of the American Thyroid Association. 27(1)
Background: 3-Iodothyronamine (3-T1AM) is an endogenous decarboxylated thyroid hormone (TH) metabolite. Pharmacological doses of 3-T1AM decrease heart rate, body temperature, and metabolic rate in rodents—effects that are contrary to classic TH exc
Autor:
Gaston J H Franssen, W. Visser, Elske T. Massolt, Boen L. R. Kam, Robin P. Peeters, J.W. Burger, M. van der Windt, Ina Lehmphul, Josef Köhrle, Tim I M Korevaar
Publikováno v:
Clinical Endocrinology, 85(5), 781-788. Wiley-Blackwell Publishing Ltd
SummaryBackground Levothyroxine (LT4) is the standard of care in patients with hypothyroidism. Despite this replacement therapy, quality of life (QoL) remains impaired in a substantial amount of patients. The reasons for this are still a matter of de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716e3619e29d8a39530d59ca2cb67bc7
https://pure.eur.nl/en/publications/0912189a-0cac-4aa1-aec9-b15ca366537f
https://pure.eur.nl/en/publications/0912189a-0cac-4aa1-aec9-b15ca366537f