Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ina Landel"'
Autor:
Lena Quambusch, Laura Depta, Ina Landel, Melissa Lubeck, Tonia Kirschner, Jonas Nabert, Niklas Uhlenbrock, Jörn Weisner, Michael Kostka, Laura M. Levy, Carsten Schultz-Fademrecht, Franziska Glanemann, Kristina Althoff, Matthias P. Müller, Jens T. Siveke, Daniel Rauh
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Elucidating specific effects of protein kinase Akt isoforms remains challenging. Here, the authors establish an Akt isoform-dependent cellular model system and use it, together with X-ray crystallography and structure-based ligand design, to develop
Externí odkaz:
https://doaj.org/article/e9d5b9b56b6e4d8f9a3489c70c876e8e
Autor:
Jonas Lategahn, Hannah L. Tumbrink, Carsten Schultz-Fademrecht, Alena Heimsoeth, Lisa Werr, Janina Niggenaber, Marina Keul, Fatma Parmaksiz, Matthias Baumann, Sascha Menninger, Eldar Zent, Ina Landel, Jörn Weisner, Kirujan Jeyakumar, Leonie Heyden, Nicole Russ, Fabienne Müller, Carina Lorenz, Johannes Brägelmann, Inga Spille, Tobias Grabe, Matthias P. Müller, Johannes M. Heuckmann, Bert M. Klebl, Peter Nussbaumer, Martin L. Sos, Daniel Rauh
Publikováno v:
Journal of Medicinal Chemistry. 65:6643-6655
Despite the clinical efficacy of epidermal growth factor receptor (EGFR) inhibitors, a subset of patients with non-small cell lung cancer displays insertion mutations in exon20 in EGFR and Her2 with limited treatment options. Here, we present the dev
Autor:
Leandi Westhuizen, Jörn Weisner, Abu Taher, Ina Landel, Lena Quambusch, Marius Lindemann, Niklas Uhlenbrock, Matthias P. Müller, Ivan R. Green, Stephen C. Pelly, Daniel Rauh, Willem A. L. Otterlo
Publikováno v:
ChemMedChem. 17
Autor:
Leandi Westhuizen, Jörn Weisner, Abu Taher, Ina Landel, Lena Quambusch, Marius Lindemann, Niklas Uhlenbrock, Matthias P. Müller, Ivan R. Green, Stephen C. Pelly, Daniel Rauh, Willem A. L. Otterlo
Publikováno v:
ChemMedChem. 17(10)
Akt is a protein kinase that has been implicated in the progression of cancerous tumours. A number of covalent allosteric Akt inhibitors are known, and based on these scaffolds, a small library of novel potential covalent allosteric imidazopyridine-b
Autor:
Niklas Uhlenbrock, Laura Depta, Jens T. Siveke, Jörn Weisner, Franziska Glanemann, Matthias P. Müller, Daniel Rauh, Lena Quambusch, Kristina Althoff, Ina Landel
Publikováno v:
Angewandte Chemie (International Ed. in English)
Isoforms of protein kinase Akt are involved in essential processes including cell proliferation, survival, and metabolism. However, their individual roles in health and disease have not been thoroughly evaluated. Thus, there is an urgent need for per
Publikováno v:
ACS Med Chem Lett
[Image: see text] The protein kinase B (Akt) exemplifies an important switch of cell death and survival within the PI3K/Akt signaling pathway, which renders Akt a valuable target in diseases such as cancer. Herein, we give a short overview of clinica
Autor:
Stephan A. Hahn, Niklas Dienstbier, Julia Hardick, Swetlana Ladigan, Anke Unger, Jan G. Hengstler, Heiner Wolters, Niklas Uhlenbrock, Heiko Muller, Rajesh Gontla, Daniel Rauh, Rebekka Scheinpflug, Richard Viebahn, Carsten Schultz-Fademrecht, Ina Landel, Lena Quambusch, Jens T. Siveke, Georgia Günther, Andrea Tannapfel, Jörn Weisner, Marius Lindemann, Marija Trajkovic-Arsic, Laura Depta, Matthias Baumann, Abdelouahid Maghnouj, Steven Smith, Christian Teschendorf, Michael Pohl, Matthias P. Müller, Christoph Reintjes, Waldemar Uhl
Aberrations within the PI3K/AKT signaling axis are frequently observed in numerous cancer types, highlighting the relevance of these pathways in cancer physiology and pathology. However, therapeutic interventions employing AKT inhibitors often suffer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba0bcaa4694c09b5e756cb17289057e
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85065516542
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85065516542
Autor:
Lena Quambusch, Daniel Rauh, Paul Czodrowski, Matthias P. Müller, Laura Depta, Jörn Weisner, Marius Lindemann, Bernd Engels, Steven Smith, Petra Janning, Ina Landel, Thien Anh Le, Rebekka Scheinpflug, Rajesh Gontla, Julia Hardick, Niklas Uhlenbrock
Publikováno v:
Chemical Science
Structure-based driven synthesis and biological evaluation provide innovative novel covalent-allosteric Akt inhibitors.
The Ser/Thr kinase Akt (Protein Kinase B/PKB) is a master switch in cellular signal transduction pathways. Its downstream sig
The Ser/Thr kinase Akt (Protein Kinase B/PKB) is a master switch in cellular signal transduction pathways. Its downstream sig
Autor:
Jörn, Weisner, Ina, Landel, Christoph, Reintjes, Niklas, Uhlenbrock, Marija, Trajkovic-Arsic, Niklas, Dienstbier, Julia, Hardick, Swetlana, Ladigan, Marius, Lindemann, Steven, Smith, Lena, Quambusch, Rebekka, Scheinpflug, Laura, Depta, Rajesh, Gontla, Anke, Unger, Heiko, Müller, Matthias, Baumann, Carsten, Schultz-Fademrecht, Georgia, Günther, Abdelouahid, Maghnouj, Matthias P, Müller, Michael, Pohl, Christian, Teschendorf, Heiner, Wolters, Richard, Viebahn, Andrea, Tannapfel, Waldemar, Uhl, Jan G, Hengstler, Stephan A, Hahn, Jens T, Siveke, Daniel, Rauh
Publikováno v:
Cancer research. 79(9)
Aberrations within the PI3K/AKT signaling axis are frequently observed in numerous cancer types, highlighting the relevance of these pathways in cancer physiology and pathology. However, therapeutic interventions employing AKT inhibitors often suffer
Publikováno v:
ChemMedChem. 13(19)
The identification of compounds for dissecting biological functions and the development of novel drug molecules are central tasks that often require screening campaigns. However, the required architecture is cost- and time-intensive. Herein we descri