Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ina Georg"'
Autor:
Miguel Lao, Rogelio Palomino, Francisca M. Real, Alicia Hurtado, F. David Carmona, Francisco J. Barrionuevo, Ina Georg, Miguel Burgos, Rafael Jiménez
Publikováno v:
Molecular Human Reproduction. 26:389-401
The identification of new genes involved in sexual development and gonadal function as potential candidates causing male infertility is important for both diagnostic and therapeutic purposes. Deficiency of the onco-miRNA cluster miR-17∼92 has been
Publikováno v:
Cellular and Molecular Immunology
Evidence supports a possible role of BANK1 in innate immune signaling in B cells. In the present study, we investigated the interaction of BANK1 with two key mediators in interferon and inflammatory cytokine production, TRAF6 and MyD88. We revealed b
Autor:
Marta E. Alarcón-Riquelme, Harini Bagavant, Mireia Castillo-Martin, Concepción Marañón, Nieves Varela, Fadi Salem, Ying-Yu Wu, Ina Georg, Bernard Lauwerys, Ramesh Kumar, Alejandro Díaz-Barreiro
Publikováno v:
Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2015, 194 (12), pp.5692-5702
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2015, 194 (12), pp.5692-5702
Polymorphisms in the B lymphoid tyrosine kinase (BLK) gene have been associated with autoimmune diseases, including systemic lupus erythematosus, with risk correlating with reduced expression of BLK. How reduced expression of BLK causes autoimmunity
Autor:
Alejandro Díaz-Barreiro, Casimiro Castillejo-López, Manuel Bernal-Quirós, Ina Georg, Concepción Marañón, Marta E. Alarcón-Riquelme
Publikováno v:
Europe PubMed Central
The B-lymphocyte kinase (BLK) gene is associated genetically with several human autoimmune diseases including systemic lupus erythematosus. We recently described that the genetic risk is given by two haplotypes: one covering several strongly linked s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e54ea3efcffa06b48b3e642724f93d
https://hdl.handle.net/10668/9787
https://hdl.handle.net/10668/9787
Autor:
Ina Georg, Kevin Christopher Knower, Gerd Scherer, Vincent R. Harley, Stefan Bagheri-Fam, Peter Wieacker
Publikováno v:
Sexual Development. 4:321-325
During mouse sex determination, SRY upregulates the core testis-specific enhancer of Sox9, TESCO. Mutations in human SRY are found in one third of cases with XY pure gonadal dysgenesis (XY GD; Swyer syndrome), while two thirds remain unexplained. Het
Autor:
Harry Scherthan, Matthias Merkenschlager, Gerd Scherer, Francisco J. Barrionuevo, Ina Georg, Florian Guillou, Gwang-Jin Kim
Publikováno v:
International Journal of Developmental Biology
International Journal of Developmental Biology, University of the Basque Country Press, 2010, 54 (5), pp.867-875. ⟨10.1387/ijdb.092874gk⟩
International Journal of Developmental Biology, University of the Basque Country Press, 2010, 54 (5), pp.867-875. ⟨10.1387/ijdb.092874gk⟩
Dicer is a key enzyme that processes microRNA precursors into their mature form, enabling them to regulate gene expression. Dicer null mutants die before gastrulation. To study Dicer function in testis development, we crossed mice carrying a conditio
Autor:
Gerd Scherer, Charlotte Lécureuil, Francisco J. Barrionuevo, Harry Scherthan, Michael Wegner, Ina Georg, Florian Guillou
Publikováno v:
Developmental Biology
Developmental Biology, Elsevier, 2009, 327 (2), pp.301-312. ⟨10.1016/j.ydbio.2008.12.011⟩
Developmental Biology, Elsevier, 2009, 327 (2), pp.301-312. ⟨10.1016/j.ydbio.2008.12.011⟩
International audience; Sox9 and Sox8 are transcription factors expressed in embryonic and postnatal Sertoli cells of the mouse testis. Sox9 inactivation prior to the sex determination stage leads to complete XY sex reversal. In contrast, there is no
Autor:
Moritz Rostásy, Hans-Henning Arnold, Mildred Kramer, Elke Troppmann, Olaf Hiort, Bernd Rösler, Michael Wegner, Friederike Denzer, Orietta Radi, Jillian R. Mann, James German, Simon Kaltenbach, Elisabeth Sock, Colm Costigan, John H Seguin, Gerd Scherer, William Zipf, Gwang-Jin Kim, Trevor Cole, Sebastian A Widholz, Peter Wieacker, Hoepffner W, Astrid Buchberger, Hardi Schmiady, Anika Salfelder, Giovanna Camerino, Ina Georg, Anne-Christin Teichmann, Walter Just
Background SOX9 mutations cause the skeletal malformation syndrome campomelic dysplasia in combination with XY sex reversal. Studies in mice indicate that SOX9 acts as a testis-inducing transcription factor downstream of SRY , triggering Sertoli cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf1bb5ebaf3476f6bdcb569220968ff
https://opus4.kobv.de/opus4-fau/files/7890/Kim_copy_number.pdf
https://opus4.kobv.de/opus4-fau/files/7890/Kim_copy_number.pdf
Autor:
Bernard Jégou, Gerd Scherer, Michael Primig, Francisco J. Barrionuevo, Philippe Demougin, Ina Georg, Frédéric Chalmel, Aurélie Lardenois
Publikováno v:
Andrology
Andrology, Wiley, 2013, 1 (2), pp.281-292. ⟨10.1111/j.2047-2927.2012.00049.x⟩
Andrology, 2013, 1 (2), pp.281-292. ⟨10.1111/j.2047-2927.2012.00049.x⟩
Scopus-Elsevier
Andrology, Wiley, 2013, 1 (2), pp.281-292. ⟨10.1111/j.2047-2927.2012.00049.x⟩
Andrology, 2013, 1 (2), pp.281-292. ⟨10.1111/j.2047-2927.2012.00049.x⟩
Scopus-Elsevier
test; International audience; The SOX8 and SOX9 transcription factors are involved in, among others, sex differentiation, male gonad development and adult maintenance of spermatogenesis. Sox8(-/-) mice lacking Sox9 in Sertoli cells fail to form testi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b0afcc6b1c9438282cafa879a6f073
https://hal.archives-ouvertes.fr/hal-00877013
https://hal.archives-ouvertes.fr/hal-00877013
Publikováno v:
Biology of Reproduction. 87
The sex-determining gene Sry and its target gene Sox9 initiate the early steps of testis development in mammals. Of the related Sox genes Sox8, Sox9, and Sox10, all expressed during Sertoli cell differentiation, only inactivation of Sox9 before the s