Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ina Bisha"'
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 12, p e1004017 (2014)
Sodium-Galactose Transporter (SGLT) is a secondary active symporter which accumulates sugars into cells by using the electrochemical gradient of Na+ across the membrane. Previous computational studies provided insights into the release process of the
Externí odkaz:
https://doaj.org/article/62974d155aa741cc8f03b67f8d7c1234
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Marker genes for the monocyte-macrophage-DC subpopulations identified in Supplementary Figure 5H. Only genes with adjusted p-value < 0.01 and average log fold-change > 0.3 were included. gene, gene name; p_val, p-value calculated based on Wilcoxon te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318ab2f876a4f6d65d1cc34e89e50b21
https://doi.org/10.1158/2159-8290.22540394
https://doi.org/10.1158/2159-8290.22540394
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Pharmacodynamics of STAT3 ASO in CT26 STK11 KO model. (A) Percentage of CD45+ immune cells among live cells from untreated or drug-treated STK11 KO CT26 tumors as indicated. (B) Percentage of Ly6G+ granulocytic cells among live CD45+ cells. (C) Perce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c1f0437b345d54961ba0824610dcb6
https://doi.org/10.1158/2159-8290.22540439.v1
https://doi.org/10.1158/2159-8290.22540439.v1
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Supplementary Appendix
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ac7dc7f83ade0389ea5b8926dfead1
https://doi.org/10.1158/2159-8290.22540454.v1
https://doi.org/10.1158/2159-8290.22540454.v1
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Mutations in the STK11 (LKB1) gene regulate resistance to PD-1/PD-L1 blockade. This study evaluated this association in patients with nonsquamous non–small cell lung cancer (NSCLC) enrolled in three phase I/II trials. STK11 mutations were associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99faa4f93ebec463e8a33a4c093c1abb
https://doi.org/10.1158/2159-8290.c.6549368.v1
https://doi.org/10.1158/2159-8290.c.6549368.v1
Autor:
Yashaswi Shrestha, Ronald Herbst, Rajiv Raja, Maria Libera Ascierto, Michael Oberst, Philip Martin, Melissa de los Reyes, Nabendu Pore, Raymond Rothstein, John Meekin, Ashok K. Gupta, Melanie M. Frigault, Stephen Blackmore, Ina Bisha, Nathan Standifer, Shaad Essa Abdullah, Theresa Proia, Matthew Griffin, Phillip A. Dennis, Rebecca A. Halpin, Song Wu, Ricardo J Miragaia, Kathy Mulgrew, J. Carl Barrett, Maria Jure-Kunkel
Publikováno v:
Cancer Discovery. 11:2828-2845
Mutations in the STK11 (LKB1) gene regulate resistance to PD-1/PD-L1 blockade. This study evaluated this association in patients with nonsquamous non–small cell lung cancer (NSCLC) enrolled in three phase I/II trials. STK11 mutations were associate
Autor:
Nabendu, Pore, Song, Wu, Nathan, Standifer, Maria, Jure-Kunkel, Melissa, de Los Reyes, Yashaswi, Shrestha, Rebecca, Halpin, Raymond, Rothstein, Kathy, Mulgrew, Stephen, Blackmore, Philip, Martin, John, Meekin, Matthew, Griffin, Ina, Bisha, Theresa A, Proia, Ricardo J, Miragaia, Ronald, Herbst, Ashok, Gupta, Shaad E, Abdullah, Rajiv, Raja, Melanie M, Frigault, J Carl, Barrett, Phillip A, Dennis, Maria Libera, Ascierto, Michael D, Oberst
Publikováno v:
Cancer discovery. 11(11)
Mutations in the
Autor:
Ina Bisha, Alessandra Magistrato
Publikováno v:
RSC advances 6 (2016): 9522–9540. doi:10.1039/c5ra22131e
info:cnr-pdr/source/autori:Bisha, Ina; Magistrato, Alessandra/titolo:The molecular mechanism of secondary sodium symporters elucidated through the lens of the computational microscope/doi:10.1039%2Fc5ra22131e/rivista:RSC advances/anno:2016/pagina_da:9522/pagina_a:9540/intervallo_pagine:9522–9540/volume:6
info:cnr-pdr/source/autori:Bisha, Ina; Magistrato, Alessandra/titolo:The molecular mechanism of secondary sodium symporters elucidated through the lens of the computational microscope/doi:10.1039%2Fc5ra22131e/rivista:RSC advances/anno:2016/pagina_da:9522/pagina_a:9540/intervallo_pagine:9522–9540/volume:6
Transport of molecules across cellular membranes is a key biological process for normal cell function. As such, secondary active transporters exploit electrochemical ion gradients to carry out fundamental processes, i.e. nutrients uptake, ion regulat
Autor:
Ina Bisha, Tanja Rasputniac, Iris Antes, Hannelore Daniel, Maren Ewers, Heiko Witt, Karolin Ebert, Simone Sander
Publikováno v:
The Journal of biological chemistry. 293(6)
Intestinal fructose uptake is mainly mediated by glucose transporter 5 (GLUT5/SLC2A5). Its closest relative, GLUT7, is also expressed in the intestine but does not transport fructose. For rat Glut5, a change of glutamine to glutamic acid at codon 166
Autor:
Arin Marchesi, Nicola Demitri, Ina Bisha, Luisa M. R. Napolitano, Matteo De March, Vincent Torre, Alex Rodriguez, Manuel Arcangeletti, Monica Mazzolini, Silvia Onesti, Alessandra Magistrato, Alessandro Laio
Publikováno v:
'Proceedings of the National Academy of Sciences of the USA ', vol: 112, pages: E3619-E3628 (2015)
Proceedings of the National Academy of Sciences of the United States of America 112 (2015): E3619–E3628. doi:10.1073/pnas.1503334112
info:cnr-pdr/source/autori:Napolitano L.M.R.; Bisha I.; De March M.; Marchesi A.; Arcangeletti M.; Demitri N.; Mazzolini M.; Rodriguez A.; Magistrato A.; Onesti S.; Laio A.; Torre V./titolo:A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels/doi:10.1073%2Fpnas.1503334112/rivista:Proceedings of the National Academy of Sciences of the United States of America/anno:2015/pagina_da:E3619/pagina_a:E3628/intervallo_pagine:E3619–E3628/volume:112
Proceedings of the National Academy of Sciences of the United States of America 112 (2015): E3619–E3628. doi:10.1073/pnas.1503334112
info:cnr-pdr/source/autori:Napolitano L.M.R.; Bisha I.; De March M.; Marchesi A.; Arcangeletti M.; Demitri N.; Mazzolini M.; Rodriguez A.; Magistrato A.; Onesti S.; Laio A.; Torre V./titolo:A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels/doi:10.1073%2Fpnas.1503334112/rivista:Proceedings of the National Academy of Sciences of the United States of America/anno:2015/pagina_da:E3619/pagina_a:E3628/intervallo_pagine:E3619–E3628/volume:112
Significance Cyclic nucleotide-gated (CNG) channels underlie sensory transduction in photoreceptors and olfactory epithelium and share a high degree of homology with K + channels. However, these channels conduct Na + and K + differently: although K +