Comparison of Alternative Methods for Bioaccumulation Assessment: Scope and Limitations of In Vitro Depletion Assays with Rainbow Trout and Bioconcentration Tests in the Freshwater Amphipod Hyalella azteca

Autor: Anna Schauerte, Christian Schlechtriem, Juliane Hollender, Ina Bischof, Verena Kosfeld, Ina Ebersbach, Qiuguo Fu, Dana Esser

Publikováno v: Environmental Toxicology and Chemistry, 39 (9)
Environmental toxicology and chemistry : ET & C online 39(9), 1813-1825 (2020). doi:10.1002/etc.4791

Bioaccumulation assessment predominantly relies on the bioconcentration factor (BCF) as the sole decisive metric. The test guideline 305 by the Organisation for Economic Co-operation and Development (OECD) provides the standard procedure for deriving

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae2ef0c21a8bde6c881d6a8baedf92e2
https://pubmed.ncbi.nlm.nih.gov/32495970

Reliability of In Vitro Methods Used to Measure Intrinsic Clearance of Hydrophobic Organic Chemicals by Rainbow Trout: Results of an International Ring Trial

Autor: John A. Weeks, Marlies Halder, Helmut Segner, Christian Schlechtriem, John W. Nichols, Ina Bischof, Jing Hu, John W. Davis, Joe Swintek, Michelle R. Embry, Karla Johanning, Kellie A. Fay, Diane L. Nabb, Heike Laue, Mary Jo Bernhard

Publikováno v: Nichols, John; Fay, Kellie; Bernhard, Mary Jo; Bischof, Ina; Davis, John; Halder, Marlies; Hu, Jing; Johanning, Karla; Laue, Heike; Nabb, Diane; Schlechtriem, Christian; Segner, Helmut; Swintek, Joe; Weeks, John; Embry, Michelle (2018). Reliability of In Vitro Methods Used to Measure Intrinsic Clearance of Hydrophobic Organic Chemicals by Rainbow Trout: Results of an International Ring Trial. Toxicological sciences, 164(2), pp. 563-575. Oxford University Press 10.1093/toxsci/kfy113
Toxicological Sciences

In vitro assays are widely employed to obtain intrinsic clearance estimates used in toxicokinetic modeling efforts. However, the reliability of these methods is seldom reported. Here we describe the results of an international ring trial designed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c166180a731a81711055f69c440a52
https://boris.unibe.ch/129626/1/kfy113.pdf

Hepatocytes as in vitro test system to investigate metabolite patterns of pesticides in farmed rainbow trout and common carp: Comparison between in vivo and in vitro and across species

Autor: Jessica Köster, Helmut Segner, Christian Schlechtriem, Ina Bischof

Publikováno v: Bischof, Ina Bettina Petra; Köster, Jessica; Segner, Helmut; Schlechtriem, Christian (2016). Hepatocytes as in vitro test system to investigate metabolite patterns of pesticides in farmed rainbow trout and common carp: Comparison between in vivo and in vitro and across species. Comparative biochemistry and physiology. Part C-toxicology and pharmacology, 187, pp. 62-73. Elsevier 10.1016/j.cbpc.2016.05.003

In vitro tools using isolated primary fish hepatocytes have been proposed as a useful model to study the hepatic metabolism of xenobiotics in fish. In order to evaluate the potential of in vitro fish hepatocyte assays to provide information on in viv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2cec66541e2c4fb0226d4f8e82e439a
https://boris.unibe.ch/97663/1/1-s2.0-S1532045616300527-main.pdf