Author Correction: Reverse engineering synthetic antiviral amyloids

Autor: Emiel Michiels, Kenny Roose, Rodrigo Gallardo, Ladan Khodaparast, Laleh Khodaparast, Rob van der Kant, Maxime Siemons, Bert Houben, Meine Ramakers, Hannah Wilkinson, Patricia Guerreiro, Nikolaos Louros, Suzanne J. F. Kaptein, Lorena Itatí Ibañez, Anouk Smet, Pieter Baatsen, Shu Liu, Ina Vorberg, Guy Bormans, Johan Neyts, Xavier Saelens, Frederic Rousseau, Joost Schymkowitz

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)

Externí odkaz: https://doaj.org/article/c25558682e604351be0ae8e8c8234335

Entropic Bristles Tune the Seeding Efficiency of Prion-Nucleating Fragments

Autor: Emiel Michiels, Shu Liu, Rodrigo Gallardo, Nikolaos Louros, Marion Mathelié-Guinlet, Yves Dufrêne, Joost Schymkowitz, Ina Vorberg, Frederic Rousseau

Publikováno v: Cell Reports, Vol 30, Iss 8, Pp 2834-2845.e3 (2020)

Summary: Prions of lower eukaryotes are self-templating protein aggregates with cores formed by parallel in-register beta strands. Short aggregation-prone glutamine (Q)- and asparagine (N)-rich regions embedded in longer disordered domains have been

Externí odkaz: https://doaj.org/article/fb35d88312474e96830afa8056164722

Viruses in neurodegenerative diseases: More than just suspects in crimes

Autor: Pascal Leblanc, Ina Vorberg

Publikováno v: PLoS pathogens 18(8), e1010670 (2022). doi:10.1371/journal.ppat.1010670

Neurodegenerative diseases (NDs) such as Alzheimer’s and Parkinson’s disease are fatal neurological diseases that can be of idiopathic, genetic, or even infectious origin, as in the case of transmissible spongiform encephalopathies. The etiologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2871fc9956f0e96095e7565da607f7e5
https://doi.org/10.1371/journal.ppat.1010670

Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils

Autor: Riza Dervisoglu, Pijush Chakraborty, Markus Zweckstetter, Ina Vorberg, Loren B. Andreas, Alina Hebestreit, Alain Ibáñez de Opakua, Shu Liu, Gwladys Rivière

Publikováno v: Nature Communications 12(1), 4231 (2021). doi:10.1038/s41467-021-24362-8
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Pathological aggregation of the protein tau into insoluble aggregates is a hallmark of neurodegenerative diseases. The emergence of disease-specific tau aggregate structures termed tau strains, however, remains elusive. Here we show that full-length

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a2adfb323aa4846b3a4d5a77b50e06
https://pub.dzne.de/record/155435

Extracellular Vesicle Separation Techniques Impact Results from Human Blood Samples: Considerations for Diagnostic Applications

Autor: Felix Babatz, Ina Vorberg, Daniel Bachurski, Uwe Völker, Theophilos Tzaridis, Kristin Surmann, Manuela Gesell Salazar, Katrin S Reiners, Shu Liu, Ulrich Herrlinger, Michael Hallek, Gunther Hartmann, Christoph Coch

Publikováno v: International journal of molecular sciences 22(17), 9211 (2021). doi:10.3390/ijms22179211 special issue: "Circulating Molecules and Precision Medicine in Cancer"
International Journal of Molecular Sciences
Volume 22
Issue 17
International Journal of Molecular Sciences, Vol 22, Iss 9211, p 9211 (2021)

Extracellular vesicles (EVs) are reminiscent of their cell of origin and thus represent a valuable source of biomarkers. However, for EVs to be used as biomarkers in clinical practice, simple, comparable, and reproducible analytical methods must be a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c439b76927c07427fef085ebbaccc48b